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Human ODZ1 Protein expressed in Wheat germ - ABIN1313341
Chand, Casatti, de Lannoy, Song, Kollara, Barsyte-Lovejoy, Brown, Lovejoy: C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells. in Molecular and cellular neurosciences 2013
Show all 2 Pubmed References
ODZ1, a protein that participates in the embryonic development of the brain, is also involved in cancer progression by promoting the growth and invasion capabilities of GSCs via a transcriptional pathway that induces the expression of RhoA (show RHOA Proteins) and activation of downstream ROCK.
Results of our study, that describes a new Tenm1 mouse, agree with the hypothesis that TENM1 has a role in olfaction. However, additional studies should be done in larger Congenital general anosmia (CGA (show CGA Proteins)) cohorts, to provide statistical evidence that loss-of-function mutations in TENM1 can solely cause the disease in our and other CGA (show CGA Proteins) cases
Data suggest teneurin-1/TENM1 (and possibly TENM3) undergoes proteolysis to TCAPs (teneurin C-terminal associated peptides) that form intercellular adhesive units with latrophilin; signaling via TENM1 TCAPs appears to regulate reproduction. [REVIEW]
This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes TENM1.
Studies indicate that teneurin-1 has been suggested as a candidate target gene for X-lined mental retardation.
The teneurin-1 intracellular domain binds HINT1, thus switching on MITF-dependent transcription of GPNMB.
Subsequent analysis showed that the deletion in both cousins was identical and involved the whole SH2D1A gene and a part of the adjacent ODZ1 gene.
Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1.
teneurin-1 plays a role in intracellular signaling
Our data provides novel evidence that TCAP-1 is structurally and functionally distinct from the larger teneurins
Our data provides novel evidence that functionally links the teneurin and dystroglycan systems and provides new insight into the molecular mechanisms by which TCAP-1 regulates cytoskeletal dynamics in hippocampal neurons
The TCAP-1 induces a significant decline in BDNF (show BDNF Proteins) transcription and protein labeling in embyronic mouse immortalized hypothalamic neurons.
These data suggest that TCAP (show TCAP Proteins) acts, in part, as a functional region of the teneurins to regulate neurite and axonal growth of neurons.
Thus, the TCAP (show TCAP Proteins)-teneurin system may be part of a mechanism to protect neurons during trauma, such as hypoxia and ischemia.
TCAP-1 attenuated the corticotropin-releasing factor (CRF (show CRH Proteins))-induced increase in c-Fos expression in the limbic system: TCAP-1 may play a potential role in the stress regulation by blocking CRF (show CRH Proteins)-mediated activity in stress-sensitive areas of the brain
The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
odz, odd Oz/ten-m homolog 1(Drosophila)
, protein Odd Oz/ten-m homolog 1
, teneurin transmembrane protein 1
, odz (odd Oz/ten-m, Drosophila) homolog 3
, odz, odd Oz/ten-m homolog 1
, tenascin M1
, teneurin 1
, odd Oz/ten-m homolog 1