Browse our Profilin 1 Proteins (PFN1)

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Profilin 1 Proteins (PFN1)
On are 28 Profilin 1 (PFN1) Proteins from 8 different suppliers available. Additionally we are shipping Profilin 1 Antibodies (89) and Profilin 1 Kits (14) and many more products for this protein. A total of 138 Profilin 1 products are currently listed.
ALS18, F6F22.21, F6F22_21, GmPRO1, GmPRO2, MGC130883, Pfn, PFN1, PRO1, profilin, profilin-1, profilin 1, Profilin1, sb:cb813, wu:fa91a03, XProfilin1
list all proteins Gene Name GeneID UniProt
PFN1 5216 P07737
PFN1 18643 P62962
PFN1 64303 P62963

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Profilin 1 Proteins (PFN1) by Origin

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Top referenced Profilin 1 Proteins

  1. Human PFN1 Protein expressed in Escherichia coli (E. coli) - ABIN666790 : Harbeck, Hüttelmaier, Schluter, Jockusch, Illenberger: Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. in The Journal of biological chemistry 2000 (PubMed)
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More Proteins for Profilin 1 Interaction Partners

Human Profilin 1 (PFN1) interaction partners

  1. Data suggest 2 major isoforms of profilin (Pfn1 and Pfn2) are co-regulated by a common mechanism involving the action of MKL1 [megakaryoblastic leukemia (translocation) 1 protein] that is independent of its SRF- (serum-response factor)-related activity; cellular externalization of Pfn1, rather than transcription, is affected by the perturbations of MKL1; MKL1 can influence cell migration by modulating Pfn1 expression.

  2. novel profilin-1 variants associated with amyotrophic lateral sclerosis

  3. We found that ARP3 (show ACTR3 Proteins) and profilin1 were 2 binding partners of LMO2 (show LMO2 Proteins), primarily in cytoplasm. LMO2 (show LMO2 Proteins). LMO2 (show LMO2 Proteins) mediated the assembly of a complex including ARP3 (show ACTR3 Proteins), profilin1, and actin monomer, increased actin monomer binding to profilin1, and promoted lamellipodia/filopodia formation in basal-type breast cancer cells.

  4. These observations indicate that our novel profilin1 mutant mouse line may provide a new ALS model with the opportunity to gain unique perspectives into mechanisms of neurodegeneration that contribute to ALS pathogenesis.

  5. These data suggest that Familial Amyotrophic Lateral Sclerosis-linked PFN1 mutations exacerbate TDP-43 (show TARDBP Proteins)-induced neurodegeneration in a gain-of-function manner, possibly by shifting the localization of TDP-43 (show TARDBP Proteins) from nuclei to cytoplasm.

  6. Homo-oligomerization of the actin-binding protein PFN1 has been characterized by the relaxation dispersion profiles of the protein as a function of concentration.

  7. Gain-of-toxic-function PFN1 gene mutation leads to conformational change of TDP-43 (show TARDBP Proteins) and to neurodegeneration in amyotrophic lateral sclerosis.

  8. Profilin synergizes with chemotherapeutic drugs to induce tumor cell death by regulating NF-kappaB (show NFKB1 Proteins) and p53 (show TP53 Proteins). Thus, modulation of Profilin may be a useful strategy for effective combination therapy.

  9. Mutations of profilin-1, associated with familial amyotrophic lateral sclerosis, increase the tendency of profilin-1 to aggregate and that such aggregation behavior is largely determined by the mutation-induced structural changes occurring in the folded state of the protein.

  10. evidence, which suggests that Profilin increases tumour suppressor activity by regulating NF-kappaB (show NFKB1 Proteins).

Mouse (Murine) Profilin 1 (PFN1) interaction partners

  1. overexpression of profilin is sufficient to induce cardiomyocyte hypertrophy and sarcomeric remodelling, and silencing of profilin attenuates the hypertrophic response

  2. Pfn1 is a novel target of BMP and suppresses BMP-induced differentiation of osteoblasts at least in part via transcriptional event.

  3. knockdown of either profilin 1 or profilin 2a led to a significant decrease in cell spreading of astrocytes. Moreover, both isoforms proved to be crucial for forskolin-induced astrocytic stellation.

  4. Inactivation of profilin 1 impaired the radial migration of cerebellar granule neurons

  5. Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like (show WASL Proteins) platelet defect.

  6. Depleting FMNL1 (show FMNL1 Proteins), another Formin (show FMN1 Proteins) family member, resulted in reduced mDia1 expression, while RhoA (show RHOA Proteins) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (show FMNL1 Proteins)-mDia1-Profilin1 signaling pathway in mouse oocytes.

  7. association of cortactin (show CTTN Proteins) with Pfn-1 is regulated by c-Abl (show ABL1 Proteins)-mediated cortactin (show CTTN Proteins) phosphorylation

  8. In glioblastomas endothelial cell-specific Pfn-1 phosphorylation elevates HIF-1alpha (show HIF1A Proteins) expression leading to vascular abnormalities and tumor progression.

  9. Pfn1 as a key effector of the integrin linked kinase/Rho/ROCK pathway which acts in parallel with integrin beta1/LCK/Rac1 and regulates Schwann cells lamellipodia formation, radial sorting and myelination during peripheral nervous system maturation.

  10. pfn1 at least partially acts through the axis of pfn1/Galpha13 (show GNA13 Proteins)/EGR1 (show EGR1 Proteins) to regulate stem cell retention and metabolism in the bone marrow.

Cow (Bovine) Profilin 1 (PFN1) interaction partners

  1. biophysical analysis reveals that the open nucleotide pocket of the profilin/actin x-ray structure is unstable and closes in the absence of profilin

  2. nitric oxide and free radicals produced under different conditions could alter the functions of profilin through nitration, such as its interaction with actin and poly (l-proline).

  3. Profilin regulates actin dynamics both within the cytoplasm and inside the nuclei of developing mammalian embryos.

  4. Phosphorylation studies indicate that profilin dimers are not phosphorylated while teramers are preferentially phosphorylated over monomers.

Arabidopsis thaliana Profilin 1 (PFN1) interaction partners

  1. PRF1 coordinates the stochastic dynamic properties of actin filaments by modulating formin-mediated actin nucleation and assembly during plant cell expansion.

  2. formed a filamentous network likely associated with actin filaments

Caenorhabditis elegans (C. elegans) Profilin 1 (PFN1) interaction partners

  1. protein CYK-1 and the profilin PFN-1 mediate the Arp2/3-independent assembly of cortical microfilaments and are required for cytokinesis in the early embryo

  2. Thus the model organism Caenorhabditis elegans expresses three profilin isoforms and is the first invertebrate animal with tissue-specific profilin expression.

  3. profilin promotes actin organisation

Profilin 1 (PFN1) Protein Profile

Protein Summary

This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1.

Alternative names and synonyms associated with Profilin 1 (PFN1)

  • profilin (PRO2)
  • profilin 1 (PFN1)
  • profilin 1 (pfn1)
  • profilin 1 (Pfn1)
  • profilin 1 (PRF1)
  • profilin 1-like (LOC100350198)
  • profilin homolog1 (prf1)
  • profilin-1-like (LOC607397)
  • Protein PFN-1 (pfn-1)
  • ALS18 protein
  • F6F22.21 protein
  • F6F22_21 protein
  • GmPRO1 protein
  • GmPRO2 protein
  • MGC130883 protein
  • Pfn protein
  • PFN1 protein
  • PRO1 protein
  • profilin protein
  • profilin-1 protein
  • profilin 1 protein
  • Profilin1 protein
  • sb:cb813 protein
  • wu:fa91a03 protein
  • XProfilin1 protein

Protein level used designations for Profilin 1 Proteins (PFN1)

profilin-2 , profilin 1 , fa91a03 , epididymis tissue protein Li 184a , profilin I , profilin-1 , actin binding protein , CL2097_1 , CL2097_1(520) , CL2097_1_ov , ZmPRO1

547670 Glycine max
710753 Macaca mulatta
735169 Xenopus laevis
799355 Danio rerio
100170559 Xenopus (Silurana) tropicalis
5216 Homo sapiens
100512494 Sus scrofa
18643 Mus musculus
64303 Rattus norvegicus
513895 Bos taurus
100723625 Cavia porcellus
816495 Arabidopsis thaliana
100350198 Oryctolagus cuniculus
542409 Zea mays
607397 Canis lupus familiaris
173161 Caenorhabditis elegans
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