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Epistasis analysis identified a statistically significant interaction between CDC42 and SCIN SNPs which are strongly associated with CDC42 and SCIN gene expression levels and map to regulatory elements in skin cells. This interaction has important biological relevance since CDC42 and SCIN proteins have opposite effects in actin cytoskeleton organization and dynamics, which underlies melanoma cell migration and invasion.
High levels of SCIN expression in gastric cancer tissue correlate with poor prognosis of patients. SCIN enhances the invasion and metastasis of GC cells through activating the Cdc42 (show CDC42 Antibodies) pathway to increase the formation of filopodia.
Suppression of scinderin impairs proliferation and migration of gastric cancer SGC7901 cells and attenuates its epithelialmesenchymal transition process.
SCIN plays an important role in lung carcinoma cell proliferation
These results suggest that SCIN plays an important role in the proliferation of prostate cancer cells and lentivirus-mediated inhibition of SCIN expression may be a potential therapeutic method for the treatment of prostate cancer
Scinderin expression does not correlate with prognosis in head and neck cancer.
calcium binding to the N terminus of adseverin dominates the activation process to expose the F-actin binding site on A2
Adseverin knockdown also suppressed the RANKL (show TNFSF11 Antibodies)-mediated induction of nuclear factor of activated T-cell (show NFATC3 Antibodies) c1 (NFATc1 (show NFATC1 Antibodies)), which is a key transcription factor in osteoclastogenesis.
Data indicate that adseverin (Ads) regulates actin cytoskeleton in osteoclasts.
Ads (show AGPS Antibodies) is a RANKL (show TNFSF11 Antibodies) induced early regulator of osteoclastogenesis with a potential role in pre-osteoclast differentiation and fusion.
adseverin induction is a specific gene regulatory effect by TCDD on thymocytes.
Overexpression of Scin is associated with asthma.
SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001
, gelsolin-like protein