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The interaction of ECD with RUVBL1, and its CK2-mediated phosphorylation, independent of its interaction with PIH1D1, are important for its cell cycle regulatory function.
Ecdysoneless and H-Ras (show HRAS Proteins) expressing human mammary epithelial cells form tumors in NOD/SCID (show PRKDC Proteins) mice.
TXNIP (show TXNIP Proteins) has a role in the pathway involving hEcd to increase p53 (show TP53 Proteins) stability and activity
Ecd (show SHFM1 Proteins) is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells.
Ecd (show SHFM1 Proteins) as a novel marker for breast cancer progression and show that levels of Ecd (show SHFM1 Proteins) expression predict poorer survival in Her2/neu (show ERBB2 Proteins) overexpressing breast cancer patients.
Ecd (show SHFM1 Proteins) localizes to both nucleus & cytoplasm & shuttles between the nucleus and cytoplasm; however, it exhibits strong nuclear export. Based on previous yeast studies & evidence provided here, we suggest that Ecd (show SHFM1 Proteins) functions as a transcriptional regulator.
The data demonstrate that ECD promotes survival upon endoplasmic reticulum stress by increasing GRP78 protein levels to enhance the adaptive folding protein in the endoplasmic reticulum to attenuate PERK signaling.
Results demonstrate that mammalian Ecd plays a role in cell cycle progression via the Rb-E2F (show E2F1 Proteins) pathway.
Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes.
ecdysoneless homolog (Drosophila)
, suppressor of S. cerevisiae gcr2
, protein SGT1
, protein ecdysoneless homolog
, suppressor of GCR2
, protein SGT1 homolog