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Human ECD Protein expressed in Baculovirus infected Insect Cells - ABIN2006142
Badzek, Kelovic, Plestina, Humar, Veir, Mihaljevic: Serum HER2/ECD value in stage I and II early breast cancer: need of a lower cut-off? in Wiener klinische Wochenschrift 2012
The interaction of ECD with RUVBL1, and its CK2-mediated phosphorylation, independent of its interaction with PIH1D1, are important for its cell cycle regulatory function.
Ecdysoneless and H-Ras (show HRAS Proteins) expressing human mammary epithelial cells form tumors in NOD/SCID (show PRKDC Proteins) mice.
TXNIP (show TXNIP Proteins) has a role in the pathway involving hEcd to increase p53 (show TP53 Proteins) stability and activity
Ecd (show SHFM1 Proteins) is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells.
Ecd (show SHFM1 Proteins) as a novel marker for breast cancer progression and show that levels of Ecd (show SHFM1 Proteins) expression predict poorer survival in Her2/neu (show ERBB2 Proteins) overexpressing breast cancer patients.
Ecd (show SHFM1 Proteins) localizes to both nucleus & cytoplasm & shuttles between the nucleus and cytoplasm; however, it exhibits strong nuclear export. Based on previous yeast studies & evidence provided here, we suggest that Ecd (show SHFM1 Proteins) functions as a transcriptional regulator.
Results demonstrate that mammalian Ecd plays a role in cell cycle progression via the Rb-E2F (show E2F1 Proteins) pathway.
Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes.
ecdysoneless homolog (Drosophila)
, suppressor of S. cerevisiae gcr2
, protein SGT1
, protein ecdysoneless homolog
, suppressor of GCR2
, protein SGT1 homolog