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anti-Human EGR1 Antibodies:
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Cow (Bovine) Polyclonal EGR1 Primary Antibody for IHC, WB - ABIN2779517
Yu, de Belle, Liang, Adamson: Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. in Molecular cell 2004
Show all 8 Pubmed References
Human Monoclonal EGR1 Primary Antibody for ELISA, WB - ABIN969092
Chan, Lee, Ho, Wong, Lam, Tang, Chan, Abdullah, Wong, Lam: High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults. in Clinica chimica acta; international journal of clinical chemistry 2009
Show all 2 Pubmed References
Human Monoclonal EGR1 Primary Antibody for IF, IHC (p) - ABIN560707
Bupha-Intr, Holmes, Janssen: Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium. in American journal of physiology. Heart and circulatory physiology 2007
Show all 2 Pubmed References
Human Polyclonal EGR1 Primary Antibody for FACS, IF - ABIN389442
Zhang, Chen, Wang, Guang, Han, Zhang, Tan, Gu: EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression. in Scientific reports 2014
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Human Polyclonal EGR1 Primary Antibody for ELISA, WB - ABIN560705
Hewetson, Chilton: Progesterone-dependent deoxyribonucleic acid looping between RUSH/SMARCA3 and Egr-1 mediates repression by c-Rel. in Molecular endocrinology (Baltimore, Md.) 2008
Chimpanzee Polyclonal EGR1 Primary Antibody for IHC (p), ELISA - ABIN2473413
El-Asrar, Missotten, Geboes: Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes. in Molecular vision 2011
Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.
Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.
Data suggest that Egr-1 protein levels may be tightly regulated in an attempt to diminish neurotoxicity or to enhance plasticity in newborn animals.
Data suggest the EGR1-miR-30a-5p-NEUROD1 axis might serve as a promising biomarker for diagnosis and treatment monitoring for schizophrenic patients in acute psychotic state. EGR1 and miR-30a-5p were remarkably downregulated, whereas NEUROD1 was significantly upregulated in PBMNCs from patients in acute psychotic state.
The Egr-1 is essential for CSE-induced MUC5AC production in HBE (show HBe1 Antibodies) cells likely through interaction with and modulation of AP-1 (show FOSB Antibodies), and re-emphasize targeting Egr-1 as a novel therapeutic strategy for COPD (show ARCN1 Antibodies).
Finally, the authors show that EGFR (show EGFR Antibodies)-ERK1/2 (show MAPK1/3 Antibodies) and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 upregulation.
Early growth response (Egr)-1 is essential for fibrotic responses to Transforming growth factor (TGF)-beta (show TGFB1 Antibodies). Egr-1 mediates TGF-beta1 (show TGFB1 Antibodies)-induced COL1A1 (show COL1A1 Antibodies) and COL1A2 (show COL1A2 Antibodies) mRNA expression and acid-soluble collagen production in buccal mucosal fibroblasts (BMFs).The epigallocatechin-3-gallate (EGCG) can block TGF-beta1 (show TGFB1 Antibodies)-induced collagen production by attenuating Egr-1 expression in BMFs.
Along with the reduction of ovarian cancer-2/disabled homolog 2 (DOC-2 (show DAB2 Antibodies)/DAB2) interactive protein (DAB2IP (show DAB2IP Antibodies)) expression, EGR-1 gene was upregulated in FI-treated cells. On the other hand, downregulation of EGR-1 gene expression sensitized radioresistant cells to IR accompanied by DAB2IP (show DAB2IP Antibodies) overexpression and STAT3 (show STAT3 Antibodies) inactivation. In addition, NF-kappaB (show NFKB1 Antibodies) inhibitor, BAY11-7082 enhanced resistant cells' radiosensitivity and chemos...
ROS (show ROS1 Antibodies) activation of the MAPK (ERK (show MAPK1 Antibodies)-1 (show MAPK3 Antibodies)/2)/Egr-1 pathway is a main player in the regulatory mechanism for cigarette smoke extract-induced PlGF (show PGF Antibodies) production. Antioxidants could partly abolish these effects.
adipose tissue-derived mesenchymal stem cells (AT-MSCs) from diabetic patients may contribute to microvascular damage and delay wound healing through the overexpression of EGR-1.
KLF12 (show KLF12 Antibodies) promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 (show KLF12 Antibodies) and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 (show KLF12 Antibodies) likely plays an important role in CRC (show CALR Antibodies) and could serve as a potential prognostic marker and therapeutic target.
Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a (show FOXO3 Antibodies)/EGR1/SIRT1 (show SIRT1 Antibodies) signaling, and AKT (show AKT1 Antibodies) and p300 (show EP300 Antibodies) negatively regulate this process via Bim (show BCL2L11 Antibodies) upregulation.
Inhibition of mTORC1-mediated 4EBP1 (show EIF4EBP1 Antibodies) phosphorylation leads to decreased expression of c-MYC (show MYC Antibodies) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 Antibodies) family member PUMA (show BBC3 Antibodies), whereas inhibition of mTORC2 (show CRTC2 Antibodies) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (show BCL2L11 Antibodies) locus encoding BIM (show BCL2L11 Antibodies).
EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG (show MYOG Antibodies) gene expression.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 (show MAPK1/3 Antibodies) and contributes to pulmonary vascular remodeling.
The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.
EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.
Low EGR1 expression is associated with cardiac ischemia and systolic dysfunction.
Herein, we report that silencing of Egr-1 in the hippocampus by shRNA reduces tau phosphorylation, lowers amyloid-beta (Abeta (show APP Antibodies)) pathology, and improves cognition in the 3xTg-Alzheimer disease mouse model.
Egr-1 is a novel regulator of drebrin (show DBN1 Antibodies) expression, which is linked to changes in dendritic spine density
In the present study, we have investigated the contribution of element C to Krox20 (show EGR2 Antibodies) expression, as it was the only characterized initiator element with an activity in r3. Using a conditional knock-out mutation of element C, we show that, unexpectedly, this element is not necessary for Krox20 (show EGR2 Antibodies) initial expression in r3.
HAS2 (show HAS2 Antibodies)-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1 (show MAPK3 Antibodies)/EGR1 signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1 (show TGFB1 Antibodies)-stimulated CD44V6/ERK (show EPHB2 Antibodies)/EGR1 signaling.
Egr1 expression is sensitive to mechanical signals in tendon cells.
age-related up-regulation of EGR1 promotes granulosa cell apoptosis in follicle atresia during ovarian aging.
data indicate that Egr-1 promotes Abeta (show APP Antibodies) synthesis via transcriptional activation of BACE-1 (show BACE Antibodies) and suggest that Egr-1 plays role in activation of BACE-1 (show BACE Antibodies) and acceleration of Abeta (show APP Antibodies) synthesis in AD brain.
EGR1, an early growth response factor, is a critical transcription factor that regulates the hepatic clock circuit.
EGR1(-/-) mouse embryonic fibroblasts demonstrated lower susceptibility to Venezuelan equine encephalitis virus-induced cell death than isogenic wild-type fibroblasts, indicating that EGR1 modulates proapoptotic pathways following virus infection.
egr1 colocalizes with tyrosine hydroxylase (show TH Antibodies) in the olfactory bulb throughout brain development.
successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish
The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization
Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.
Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.
Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12 (show GDF7 Antibodies)/Smad1 (show SMAD1 Antibodies)/5/8 pathway.
Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB (show CREB1 Antibodies)-mediated transactivation.
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.
early growth response protein 1(Egr-1, NGFI-A)
, early growth response protein 1 (egr-1)
, early growth response 1
, early growth response protein 1
, nerve growth factor-induced protein A
, transcription factor ETR103
, transcription factor Zif268
, zinc finger protein 225
, zinc finger protein Krox-24
, Krox-24 nuclear protein
, zinc finger protein ZENK
, zinc-finger transcriptional protein
, early growth response protein 1-A