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Antihistamines displayed similar kinetic signatures on antagonizing histamine-induced beta-arrestin2 (show ARRB2 ELISA Kits) recruitment as compared to displacing radioligand binding from the H1R.
Study suggests that both MAPK (show MAPK1 ELISA Kits) p44/p42 (show PSMC6 ELISA Kits) and PKC pathways appear to be involved in histamine-upregulated matrix metalloproteinase-9 (show MMP9 ELISA Kits) release via histamine H1 receptors in astrocytes.
that histamine H1 receptor activation mediates MAPK activation through PLCbeta, Src, PKCdelta and MEK pathway, but does not lead to nuclear relocalization of phospho-ERK (pERK), classically associated with pro-proliferative changes.
Activation of the H1R by its full agonists resulted in a composite potentiating effect. Intriguingly, inactivation of the Gaq (show GNAQ ELISA Kits)-PLC (show HSPG2 ELISA Kits) pathway by H1R inverse agonists resulted also in a potentiation of GR activity.
HRH1 (show DHX8 ELISA Kits)-mediated sensitization of TRPV1 (show TRPV1 ELISA Kits) is involved in IBS. Ebastine, an antagonist of HRH1 (show DHX8 ELISA Kits), reduced visceral hypersensitivity, symptoms, and abdominal pain in patients with IBS.
HRH1 (show DHX8 ELISA Kits)-17 TT and HNMT (show HNMT ELISA Kits)-1639 TT genotypes were associated with the allergic asthma phenotype among African-American children and that the ABP (show ABP1 ELISA Kits) 4107 GG genotype was associated with nonallergic asthma among white children.
HRH1 (show DHX8 ELISA Kits) transcript was significantly down-modulated in multiple sclerose compared with health control.
The relationship between the expression of HRH1 (show DHX8 ELISA Kits) and prognosis was found to vary in different types of cancers, even in the same cancer from different databases.
But carriers of one or three copies of HRH1 (show DHX8 ELISA Kits) (5% of individuals), HRH2 (show DHX15 ELISA Kits) (1.1%) and HRH4 (show HRH4 ELISA Kits) genes (0.9%) were also identified.
Overexpression of H1R further increases the oxidative output of Duox (show DUOX1 ELISA Kits)-expressing HEK (show EPHA3 ELISA Kits)-293 cells.
Sympathetic tone changed in H1R-, but not H2R (show HRH2 ELISA Kits)- or H3R (show HRH3 ELISA Kits)-null mice.
The results of this study suggest that H1R deficiency in mice is associated with pronounced deficits in hippocampus-dependent spatial learning and memory.
histamine receptor H1 and histamine receptor H2 (show HRH2 ELISA Kits) reciprocally regulate inflammation in the ligation-induced arteriosclerosis
Histamine demonstrably inhibited ACh (show FGFR3 ELISA Kits)-induced sweating in both mice and humans via H1R-mediated signaling.
This study provides a potential mechanism of H1R-mediated signaling and NF-kB pathway crosstalk in allergic inflammationptor
Neuronal damage is significantly increased in H1R knock-out mice following status epilepticus.
Histamine H1 Receptor expression by CD11B (show ITGAM ELISA Kits)(+) cells is not required for susceptibility to experimental allergic encephalomyelitis.
histamine signaling through the H1R on dendritic cells is an important early event conditioning the quality of the skin effector immune response.
endothelial H(1)R expression reduces BBB (show ALMS1 ELISA Kits) permeability, suggesting that endothelial H(1)R signaling may be important in the maintenance of cerebrovascular integrity
Regulation of sleep/wake states is completely achieved by OX(2)R (show HCRTR2 ELISA Kits)-expressing neurones without involving H(1)R-mediated pathways. Maintenance of basal physiological sleep/wake states is fully achieved without both H(1) and OX(1 (show NQO1 ELISA Kits)) receptors.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
Histamine H1 receptor mRNA is detected in horizontal cell perikarya and primary dendrites of retina.
The histaminergic system regulates wakefulness and orexin/hypocretin (show OX ELISA Kits) neuron development via histamine receptor H1.
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, histamine H(1) receptor
, histamine H1 receptor
, histamine receptor, subclass H1
, Bordetella pertussis induced histamine sensitization
, histamine receptor subtype H1
, histamine receptor H1
, 7 transmembrane receptor