Browse our CXCL12 Proteins (CXCL12)

Full name:
Chemokine (C-X-C Motif) Ligand 12 Proteins (CXCL12)
On are 156 Chemokine (C-X-C Motif) Ligand 12 (CXCL12) Proteins from 20 different suppliers available. Additionally we are shipping CXCL12 Antibodies (200) and CXCL12 Kits (83) and many more products for this protein. A total of 449 CXCL12 products are currently listed.
a-sdf1a, IRH, Pbsf, Scyb12, SDF-1, sdf1, sdf1a, Tlsf, Tpar1, xSDF-1
list all proteins Gene Name GeneID UniProt
CXCL12 6387 P48061
CXCL12 20315 P40224
CXCL12 24772  

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CXCL12 Proteins (CXCL12) by Origin

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Top referenced CXCL12 Proteins

  1. Human CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN2666799 : Davis, Singer, De La Luz Sierra, Narazaki, Yang, Fales, Yarchoan, Tosato: Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation. in Blood 2005 (PubMed)
    Show all 8 references for 2666799

  2. Dog (Canine) CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN2008901 : Bleul, Farzan, Choe, Parolin, Clark-Lewis, Sodroski, Springer: The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. in Nature 1997 (PubMed)
    Show all 5 references for 2008901

  3. Rhesus Monkey CXCL12 Protein expressed in Human Cells - ABIN2009688 : Orimo, Gupta, Sgroi, Arenzana-Seisdedos, Delaunay, Naeem, Carey, Richardson, Weinberg: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. in Cell 2005 (PubMed)
    Show all 5 references for 2009688

  4. Human CXCL12 Protein expressed in Human Cells - ABIN2002109 : Sapède, Rossel, Dambly-Chaudière, Ghysen: Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 5 references for 2002109

  5. Human CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN2005762 : Delgado, Clark-Lewis, Loetscher, Langen, Thelen, Baggiolini, Wolf: Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes. in European journal of immunology 2001 (PubMed)
    Show all 5 references for 2005762

  6. Human CXCL12 Protein expressed in Escherichia coli (E. coli) - ABIN413780 : Basu, Broxmeyer: Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12. in Blood 2005 (PubMed)
    Show all 4 references for 413780

More Proteins for CXCL12 Interaction Partners

Rhesus Monkey Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. these results demonstrate that a cross-talk exists between the TGF-beta1 (show TGFB1 Proteins) and SDF-1 pathways in choroid-retinal endothelial cells

  2. following optic nerve crush, the levels of endogenous SDF-1alpha and CXCR4 (show CXCR4 Proteins) increase in the retina and optic nerve, where activated glial cells may act as a source of increased SDF-1alpha protein.

  3. The CXCR7/CXCR4 (show CXCR4 Proteins)/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.

Medaka Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. primordial germ cell movements are shown to be the consequence of a combination of active SDF1a and SDF1b-guided migration; both SDF1 co-orthologues show only partly overlapping expression pattern and cooperate in the correct positioning of the PGCs

Human Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. The study demonstrated that monomeric CXCL12 was the fundamental form, which played important roles in endothelial progenitor cells' proliferation, migration, and tube-formation.

  2. the A allele and AA genotype of the SDF1- rs1111875 polymorphism produce a significant risk of MI. the GG genotype of the SDF1-rs1111875 polymorphism provides a protective effect on MI in a recessive model (GG vs. AA+AG)

  3. These results suggest that that CXCL14 (show CXCL14 Proteins) is a positive allosteric modulator of CXCR4 (show CXCR4 Proteins) via CXCL12 that enhances the potency of CXCR4 (show CXCR4 Proteins) ligands.

  4. High SDF1 expression is associated with Hepatocellular Carcinoma.

  5. GATA2 (show GATA2 Proteins) deficiency is associated with impaired membrane expression and chemotactic dysfunctions of CXCR4 (show CXCR4 Proteins).

  6. this study shows that CXCL12 conveys epithelial-mesenchymal transition -promoting signals in neuroendocrine tumors cells through CXCR4 (show CXCR4 Proteins)

  7. tumor microenvironment stimulation down-regulated the migration of CCR7 (show CCR7 Proteins)-expressing tumor cells toward CCL21 (show CCL21 Proteins) and inhibited the formation of directional protrusions toward CCL21 (show CCL21 Proteins) in a novel 3-dimensional hydrogel system.

  8. These findings suggest the tumor suppressor functions of CXCL12 in cervical cancer.

  9. Expressions of SDF-1, survivin (show BIRC5 Proteins) and smac (show DIABLO Proteins) were significantly higher in epithelial ovarian cancer tissue than those in normal tissue.

  10. These data identified the IL-4 (show IL4 Proteins)/CXCL12 loop as a previously unrecognized pathway involved in lymphoid stroma polarization and as a potential therapeutic target in Follicular lymphoma patients.

Mouse (Murine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. CXCL12 upregulation prior to stroke onset, and its actions following stroke, contribute to the endogenous, anti-inflammatory phenotype induced by repetitive hypoxic preconditioning

  2. Results suggest that SDF-1/CXCR4 (show CXCR4 Proteins) signaling plays an important role in the dynamics associated with adult sub-ventricular zone lineage cell proliferation and differentiation.

  3. TNF (show TNF Proteins) plays an inhibitory role in modulating myocardial SDF-1 production and blockade of TNF (show TNF Proteins) signaling by ablation of TNFR1 (show TNFRSF1A Proteins) and TNFR2 (show TNFRSF1B Proteins) genes increased SDF-1 expression in the heart. These data expand on TNF (show TNF Proteins) signaling-initiated mechanisms in myocardium, which may lend a more complete understanding of SDF-1 and TNFR (show TNFRSF1A Proteins)-derived actions in hopes of advancing ischemic heart injury treatments.

  4. CD26 (show DPP4 Proteins)-cleavage skews CXCL12 towards beta-arrestin dependent recruitment through ACKR3 and destroys the CXCR4 (show CXCR4 Proteins)-mediated lymphocyte chemoattractant properties of CXCL12 in vivo

  5. these data highlight AnxA1 (show ANXA1 Proteins) as a novel determinant of neutrophil maturation and the mechanisms behind blood neutrophil homing to BM via the CXCL12/CXCR4 (show CXCR4 Proteins) pathway.

  6. CXCL12/CXCR4 (show CXCR4 Proteins) regulates HA and LG following corneal suture placement, and provides a novel strategy to inhibit LG. Notably, the present study is the first to demonstrate evidence that CXCL12/CXCR4 (show CXCR4 Proteins) modulates LG in a corneal suture-induced mouse model.

  7. Female MRL/lpr (show FAS Proteins) mice treated with dual blockade of the chemokines CCL2 (show CCL2 Proteins) and CXCL12 showed significantly more effective than either monotherapy in preventing proteinuria and immune complex glomerulonephritis.

  8. the present study indicates that the CXCL12/CXCR4 (show CXCR4 Proteins) signaling pathway is important during the development of cochleae in neonatal mice.

  9. crosstalk between astrocytic CXCL12 and microglial CXCR4 (show CXCR4 Proteins) in the pathogenesis of neuropathic pain.

  10. A model of SDF-1 regulation in the hypoxia pathway was constructed; the underlying mechanisms of SDF-1 kinetics and a novel incoherent feed forward loop regulating SDF-1 expression were proposed.

Xenopus laevis Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7

  2. SDF-1/CXCR4 chemokine (show CCL1 Proteins) signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus

  3. A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls.

  4. SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation.

Pig (Porcine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. Polymorphisms in CXCL12 are significantly associated with immunological traits in Landrace piglets and have potential application value for marker-assisted selection of pig breeding with disease resistance.

  2. The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 (show CXCR4 Proteins) axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.

Cow (Bovine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

  1. There is a potential link between follicular SDF1/CXCR4 (show CXCR4 Proteins) activation and the regulation of ovulation-related genes in cows and horses.

  2. Polymorphism of intron 2 of the SDF1 gene in Galloway, Hereford, and Russian Black Pied cattle

CXCL12 Protein Profile

Protein Summary

This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CXCL12

  • chemokine (C-X-C motif) ligand 12 (CXCL12)
  • CXCL12 (LOC100304642)
  • stromal cell-derived factor 1a (sdf1a)
  • stromal cell-derived factor 1a (a-sdf1a)
  • chemokine (C-X-C motif) ligand 12 (Cxcl12)
  • chemokine (C-X-C motif) ligand 12 (cxcl12)
  • a-sdf1a protein
  • IRH protein
  • Pbsf protein
  • Scyb12 protein
  • SDF-1 protein
  • sdf1 protein
  • sdf1a protein
  • Tlsf protein
  • Tpar1 protein
  • xSDF-1 protein

Protein level used designations for CXCL12

chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) , chemokine CXCL12/SDF-1ALPHA , stromal cell-derived factor 1 , stromal cell-derived factor 1 isoform alpha , stromal cell-derived factor 1 isoform gamma , CXCL12 , stromal cell-derived factor 1a , intercrine reduced in hepatomas , pre-B cell growth-stimulating factor , 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 , pre-B-cell growth-stimulating factor , thymic lymphoma cell-stimulating factor , C-X-C motif chemokine 12 , stromal-derived factor 1 , chemokine ligand 12b , stromal cell derived factor 1 , stromal cell-derived factor-1 beta , CXC chemokine , CXCL12 chemokine , SDF-1 gamma , Stromal cell-derived factor 1 , stromal cell-derived factor-1 gamma

574334 Macaca mulatta
100173045 Pongo abelii
100304642 Ictalurus punctatus
100049305 Oryzias latipes
100170634 Oryzias latipes
6387 Homo sapiens
20315 Mus musculus
399030 Xenopus laevis
395180 Gallus gallus
449622 Canis lupus familiaris
494460 Sus scrofa
613811 Bos taurus
24772 Rattus norvegicus
100721137 Cavia porcellus
493806 Felis catus
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