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anti-Mouse (Murine) CXCR4 Antibodies:
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Human Monoclonal CXCR4 Primary Antibody for CyTOF, FACS - ABIN4900744
Griffiths, Dolezal, Cao, Nilsson, See, Pfleger, Roche, Gorry, Pow, Viduka, Lim, Lu, Chang, Murray-Rust, Kvansakul, Perugini, Dogovski, Doerflinger, Zhang, Parisi, Casey, Nuttall, Foley: i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4. in The Journal of biological chemistry 2016
Show all 24 Pubmed References
Human Monoclonal CXCR4 Primary Antibody for CyTOF, FACS - ABIN4900745
Hansson, Olesen, Peterslund, Engberg, Kahn, Winzi, Klein, Maddox-Hyttel, Serup: A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. in Developmental biology 2009
Show all 21 Pubmed References
Human Monoclonal CXCR4 Primary Antibody for FACS - ABIN4898487
Peled, Abraham, Avivi, Rowe, Beider, Wald, Tiomkin, Ribakovsky, Riback, Ramati, Aviel, Galun, Shaw, Eizenberg, Hardan, Shimoni, Nagler: The high-affinity CXCR4 antagonist BKT140 is safe and induces a robust mobilization of human CD34+ cells in patients with multiple myeloma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Show all 17 Pubmed References
Human Monoclonal CXCR4 Primary Antibody for FACS - ABIN4898488
Muller, Sonkoly, Eulert, Gerber, Kubitza, Schirlau, Franken-Kunkel, Poremba, Snyderman, Klotz, Ruzicka, Bier, Zlotnik, Whiteside, Homey, Hoffmann: Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy. in International journal of cancer 2006
Show all 17 Pubmed References
Human Monoclonal CXCR4 Primary Antibody for CyTOF, FACS - ABIN4900746
Albanesi, Scarponi, Pallotta, Daniele, Bosisio, Madonna, Fortugno, Gonzalvo-Feo, Franssen, Parmentier, De Pità, Girolomoni, Sozzani: Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. in The Journal of experimental medicine 2009
Show all 15 Pubmed References
Mouse (Murine) Monoclonal CXCR4 Primary Antibody for CyTOF, FACS - ABIN4899088
Rider, Carmi, Guttman, Braiman, Cohen, Voronov, White, Dinarello, Apte: IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 15 Pubmed References
Human Polyclonal CXCR4 Primary Antibody for ICC, IF - ABIN261500
Hasegawa, McLeod, Prow, Merges, Grebe, Lutty: Vascular precursors in developing human retina. in Investigative ophthalmology & visual science 2008
Show all 14 Pubmed References
Human Polyclonal CXCR4 Primary Antibody for FACS, IF (p) - ABIN730888
Zhuo, Jia, Song, Lu, Ding, Wang, Song, Fu, Luo: The CXCL12-CXCR4 chemokine pathway: a novel axis regulates lymphangiogenesis. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Show all 12 Pubmed References
Human Polyclonal CXCR4 Primary Antibody for ICC, IF - ABIN4301203
Kulbe, Hagemann, Szlosarek, Balkwill, Wilson: The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells. in Cancer research 2005
Show all 12 Pubmed References
Human Monoclonal CXCR4 Primary Antibody for FACS - ABIN2689042
Hesselgesser, Halks-Miller, DelVecchio, Peiper, Hoxie, Kolson, Taub, Horuk: CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. in Current biology : CB 1997
Show all 10 Pubmed References
bilateral lineup in the trunk before PGC migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor gene cxcr4b
CXCL12 (show CXCL12 Antibodies)/CXCR4 signaling negatively modulates the bipotential state of Hemogenic endothelial cells independently of the hematopoietic fate.
Efficient plasma cell differentiation and trafficking require Cxcr4 desensitization.
High CXCR4 expression is associated with Prostate Cancer.
Data show that FLT3 ligand (FLT3L (show FLT3LG Antibodies)) enhances thymopoiesis through increased survival and export of hematopoietic stem cell (Lin([minus])Sca1 (show ATXN1 Antibodies)(+)c-Kit (show KIT Antibodies)(+) [LSK (show LCK Antibodies)] cells via CXCR4 receptor regulation.
Adipocytes promoted osteoclast differentiation, function and expression of adhesion-related molecules through the CXCL12 (show CXCL12 Antibodies)/CXCR4 signalling pathway.
Efficient Cxcr4 desensitization is critical for lymphoid differentiation of hematopoietic stem and progenitor cell (HSPC (show PSMA7 Antibodies)), and its impairment is a key mechanism underpinning the lymphopenia observed in mice and likely in WHIM Syndrome (WS) patients.
COUP-TFI (show NR2F1 Antibodies) is required predominantly in Dentate gyrus progenitors for modulating expression of the Cxcr4 receptor during granule cell neurogenesis and migration.
CXCR4, CCR2 (show CCR2 Antibodies), and CX3CR1 (show CX3CR1 Antibodies) direct dendritic cell precursors from the bone marrow to the lung differentially.
data suggest that prolonged but reversible pharmacologic blockade of the CXCR4/CXCL12 axis represents an approach that releases HSPC with efficiency superior to any other known mobilization strategy and may also serve as an effective method to expand the BM HSPC pool.
role of MIM (show MTSS1 Antibodies) in the homeostasis of BM cells, including HSPCs, through modulation of the CXCR4/SDF-1 (show CXCL12 Antibodies) axis and interactions of BM leukocytes with their microenvironments.
findings indicate that CXCR4 activation attenuates thrombin (show F2 Antibodies)-induced lung endothelial barrier function impairment and suggest that protective effects of CXCL12 (show CXCL12 Antibodies) are dictated by its CXCR4 agonist activity and interactions of distinct protein moieties with heparan sulfate on the endothelial surface
Together, these data indicate that different mechanisms govern the flow response across GSCs, but that within a single patient, there are subpopulations of GSCs that respond to flow via either CD44 (show CD44 Antibodies)- or CXCR4-CXCL12 (show CXCL12 Antibodies) mechanisms.
JAM (show F11R Antibodies) family members differentially regulate CXCR4 function and CXCL12 (show CXCL12 Antibodies) secretion in the bone marrow niche.
through its interaction with CXCR4 and the actin cytoskeleton, drebrin (show DBN1 Antibodies) regulates T cell activation. CD4 (show CD4 Antibodies)(+) T cells are one of the main targets for the human immunodeficiency virus (HIV)-1.
Data indicate that a constitutively monomeric CXCL12 (show CXCL12 Antibodies) variant reproduced the G protein-dependent and beta-arrestin-dependent responses that are associated with normal CXCR4 signaling and lead to cell migration.
High CXCR4 expression is associated with chronic lymphocytic leukaemia in comparison to small lymphocytic lymphoma.
SDF-1 (show CXCL12 Antibodies)/CXCR4 axis plays a crucial role in engraftment; however, more studies are warranted to assess their expression post-transplant.
In conclusion, BPIFB4 (show BPIFB4 Antibodies) and CXCR4 expression classify long-lived individuals health status that correlates with maintained mononuclear cell migration.
HS had no effects on the binding of CXCL12alpha to CXCR4 or its biological activity, suggesting that this polysaccharide controls CXCL12 (show CXCL12 Antibodies) in an isoform-specific manner.
CXCR4-tropic HIVs infect a broad range of HSPC subtypes, including hematopoietic stem cells, which are multi-potent and long-lived.
CXCR4 controls leukocyte mobilization after trauma.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1 (show CXCL12 Antibodies)/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
reports transmural and perivascular expression patterns of chemokines CCL2 (show CCL2 Antibodies) and CXCL2 (show CXCL2 Antibodies) and of chemokine (show CCL1 Antibodies) receptors CCR2 (show CCR2 Antibodies), CCR5, and CXCR4 following coronary angioplasty
The current analysis failed in identifying a causal mutation on the CXCR4 gene underlying a previously reported quantitative trait loci for cattle trypanotolerance on bovine chromosome 2.
There is a potential link between follicular SDF1 (show CXCL12 Antibodies)/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
The combination of low expression of CXCR4 and high expression of IL-10 (show IL10 Antibodies) might be closely concerned with some bias for the production of PI calves.
The increased CXCR4 and CXCR7 (show CXCR7 Antibodies) expression resulted in increased SDF-1 (show CXCL12 Antibodies)-induced RF/6A cell migration and tube formation.
The CXCR7 (show CXCR7 Antibodies)/CXCR4/CXCL12 (show CXCL12 Antibodies) axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
These findings suggest that FBLN5 (show FBLN5 Antibodies) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Antibodies), CXCR4, and TGFB1 (show TGFB1 Antibodies) expression and inhibiting choroidl endothelial cell proliferation.
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.
SDF1a (show CXCL12 Antibodies) directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7 (show CXCR7 Antibodies).
Hoxb8a is induced by and cooperates with Wnt (show WNT2 Antibodies) signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.
Expression of Cxcr4 and Cxcl12 (show CXCL12 Antibodies) in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12 (show CXCL12 Antibodies)/Cxcr4 pair in brain development and functioning.
show that inactivation of the estrogen receptor ESR1 (show ESR1 Antibodies) results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 (show ESR1 Antibodies) overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.
A CXCR4-like chemokine receptor is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1 (show CXCL12 Antibodies)-CXCR4 system.
Knocking down CXCR4 results in severe defects in primordial germ cell migration.
SDF-1 (show CXCL12 Antibodies)/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.
chemokine (show CCL1 Antibodies) signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
C-X-C chemokine receptor type 4
, SDF-1 receptor
, Stromal cell-derived factor 1 receptor
, chemokine (C-X-C motif) receptor 4
, chemokine (C-X-C) receptor 4
, chemokine receptor 4
, leukocyte-derived seven transmembrane domain receptor
, leukocyte-expressed seven-transmembrane-domain
, pre-B-cell-derived chemokine receptor
, stromal cell-derived factor 1 receptor
, CXC chemokine receptor
, chemokine receptor (LCR1)
, CD184 antigen
, leukocyte-derived seven-transmembrane-domain receptor
, lipopolysaccharide-associated protein 3
, neuropeptide Y receptor Y3
, seven transmembrane helix receptor
, seven-transmembrane-segment receptor, spleen
, C-X-C chemokine receptor type 4-B
, SDF-1 receptor B
, SDF-1 receptor-B
, Stromal cell-derived factor 1 receptor-B
, stromal cell-derived factor 1 receptor B
, chemokine receptor CXCR4
, CXC chemokine receptor 4