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High HSP90B expression is associated with laryngeal carcinoma.
The expression level of Hsp90AB1 in lung cancer tissues was significantly higher than that in normal lung tissue and was associated with lung cancer pathological type and overall survival in lung adenocarcinoma patients.
We revealed that Hsp90A (show HSP90AA1 Proteins) and Hsp90B are partly colocalized with heparan sulfate proteoglycans (HSPGs) on the cell surface and that this colocalization was sensitive to heparin.
Apart from these distinct Cdc37/Hsp90 interfaces, binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes.
HSP90AB1: Helping the good and the bad
These results suggest a means by which the hsp90beta interaction could prevent apo (show C9orf3 Proteins)-sGCbeta1 from associating with its partner sGCalpha1 subunit while enabling structural changes to assist heme insertion into the H-NOX domain.
Casein kinase 2-mediated phosphorylation of Hsp90beta and stabilization of PXR (show NR1I2 Proteins) is a key mechanism in the regulation of MDR1 expression.
This study identifies overexpression of HSP90 (show HSP90 Proteins) (especially isoform HSP90AB1) and its clients ATR (show ANTXR1 Proteins), ATM (show ATM Proteins), and NBS1 (show NBN Proteins) as promising markers for radioresistant, aggressive soft tissue sarcomas with particularly poor prognosis.
The proteins (HSP90b, TMS1 (show SERINC3 Proteins) and L-plastin (show LCP1 Proteins)) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases.
The expression levels of Hsp90-beta and annexin A1 (show ANXA1 Proteins) positively correlated and such co-overexpression of Hsp90-beta and annexin A1 (show ANXA1 Proteins) contributed to lung cancer diagnosis.
This gene encodes a member of the heat shock protein 90 family\; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes.
, heat shock 84 kDa
, heat shock 90kD protein 1, beta
, heat shock protein HSP 90-beta