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Slit3 (and slit-2 (show SLIT2 Proteins)) coordinate neuron axonal pathfinding within the embryonic axon tracts along with Robo2 (show ROBO2 Proteins) and Dcc (show DCC Proteins)-Netrin1.
Data show that Hedgehog (show SHH Proteins) signaling is required for commissure formation, glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2 (show SLIT2 Proteins), slit3 and sema3d (show SEMA3D Proteins).
Overexpression of Slit3 (show SLIT1 Proteins) induces its tumor suppressive effects in Breast cancer.
Results show that silencing of Slit3 (show SLIT1 Proteins) promoted proliferation, migration and invasion of A549 cells and induced epithelial-mesenchymal transition suggesting that Slit3 (show SLIT1 Proteins) functions as a tumor suppressor in lung carcinoma.
Estrogen-dependent expression of SLIT3 (show SLIT1 Proteins) may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions.
SLIT3 (show SLIT1 Proteins) is increased with labour, and both amnion and myometrial studies describe a pro-inflammatory effect of SLIT3 (show SLIT1 Proteins) in these tissues.
High SLIT3 (show SLIT1 Proteins) expression is associated with high-grade gliomas.
SLIT3 (show SLIT1 Proteins)-ROBO4 (show ROBO4 Proteins) activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo.
results implicate the involvement of miR (show MLXIP Proteins)-218-2 and its host gene SLIT3 (show SLIT1 Proteins) in thyroid cancer cell invasion, migration, and proliferation
Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo.
three major members (Slit2/3 and Robo1 (show ROBO1 Proteins)) of Slit/Robo family are widely expressed in the human normal and malignant ovarian tissues; but Slit/Robo signaling may not play an important role in regulating human ovarian cancer cell proliferation and migration
SLIT3 (show SLIT1 Proteins) duplication on 5q35.1 predisposes to major depressive disorder
While Slit1 (show SLIT1 Proteins) and Robo2 (show ROBO2 Proteins) are only expressed in peripheral axons and their cell bodies, Slit2 (show SLIT2 Proteins), Slit3 and Robo1 (show ROBO1 Proteins) are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves.
Heparan sulfate-deficient mouse endothelial cells was used to determine the co-reception function of heparan sulfate in Slit3-induced endothelial cell migration.
FREM1-deficient mice faithfully recapitulate many of the phenotypes seen in individuals with FREM1 deficiency and that variations in GATA4 and SLIT3 expression modulate some FREM1-related phenotypes in mice.
Report role of Slit3 in development of the caval veins and pericardium.
Robo-2 (show ROBO2 Proteins)-mediated targeting of P2 axons along the dorsoventral axis of the OB is controlled by Slit-3 expression
Study identify that the homeobox (show PRRX1 Proteins) gene Nkx2-5 (show NKX2-5 Proteins) is required for early ventral restriction of Slit3 and that the T-box transcription factor Tbx2 (show TBX2 Proteins) mediates repression of Slit3 in nonchamber myocardium.
The chemorepellent Slit3 promotes monocyte migration.
During blood vessel development, Slit3 gene expression (and that of Slit2) are linked to posttranscriptional regulation of Robo receptors.
Data suggest that the Slit family of axon guidance molecules (Slit 1 (show SLIT1 Proteins)-3) and their Robo 1 (show ROBO1 Proteins) and 2 receptors contribute to the topographic targeting of basal vomeronasal axons.
Experiments with triple mutant mice demonstrate a key role for Slit3 signaling in vertebrate midline commissural axon guidance.
The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene.
slit homolog 3
, slit homolog 3 protein
, slit homolog 3 (Drosophila)
, slit homolog 3 protein-like
, multiple EGF-like domains protein 5
, multiple epidermal growth factor-like domains protein 5
, multiple epidermal growth factor-like domains 5