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Hepatic Axin2 expressing CD90 (show THY1 ELISA Kits)+ cells play a cancer stem cell-like role in the progression from liver cirrhosis to hepatocarcinoma.
role in the formation of degradasomes and degradation of beta-catenin (show CTNNB1 ELISA Kits) induced by the TNKSi G007-LK in colorectal cancer cells
AXIN2 overexpression is associated with Breast Cancer Invasion and Metastasis.
the study reveals a strong association of SNPs in the Axin2 gene with lung cancer risk in North Indians.
Genetic variant in AXIN2 gene is associated with gallbladder cancer.
Data show that SS18 (show SS18 ELISA Kits)/SSX tightly regulates the elevated expression of the key Wnt (show WNT2 ELISA Kits) target AXIN2 in primary synovial sarcoma.
our mutation analysis detected already known mutations as well as, to the best of our knowledge, mutations and an interstitial deletion of CTNNB1 (show CTNNB1 ELISA Kits) not described in JAs (show TAP2 ELISA Kits) before. Additionally, a so far unknown transcribed Axin2 splice variant was found, but no further Axin2 mutations.
miR (show MLXIP ELISA Kits)-374a functions as an oncogene (show RAB1A ELISA Kits) in osteosarcoma, and the miR (show MLXIP ELISA Kits)-374a/Axin2 axis might represent a potential therapeutic target for OS intervention.
Flow cytometrically sorted CA9 (show CA9 ELISA Kits)+ population showed increased mRNA level of a Wnt (show WNT2 ELISA Kits) signaling factor AXIN2. In conclusion, these observations indicate that CA9 (show CA9 ELISA Kits) expression in normal crypt base cells has association with intestinal epithelial stemness
Increase in AXIN2 level expression is associated with breast cancer.
beta-catenin1 cannot revert the ich (show ACE ELISA Kits) phenotype because it may be under the control of a GSK3beta (show GSK3b ELISA Kits)-independent mechanism that required Axin's RGS (show PITX2 ELISA Kits) domain function.
Barx2 (show BARX2 ELISA Kits) and Pax7 (show PAX7 ELISA Kits) regulate the canonical Wnt (show WNT2 ELISA Kits) target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt (show WNT2 ELISA Kits) signals.
Axin2 limits Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signalling resulting from loss of Axin2 leads to progressive myxomatous valve disease.
Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers
Our results reveal a critical role for Axin2 during ocular development, likely by restricting the activity of the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway.
The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis
Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
Axin2-expressing prostatic cells express epithelial cell markers and are able to expand cell lineage during prostatic development and maturation.
Axin1 (show AXIN1 ELISA Kits) and Axin2 do not have equivalent functions in satellite cells, but are both involved in repression of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.
These data demonstrate a dominant role for Runx2 (show RUNX2 ELISA Kits) in chondrocyte maturation, but implicate Axin2 as an important modulator of the terminal stages of endochondral bone formation.
implants lacking primary stability undergo osseointegration, provided Wnt (show WNT2 ELISA Kits) signalling is amplified. Fibrous encapsulation can be prevented and osseointegration assured if Wnt (show WNT2 ELISA Kits) signalling is elevated at the time of implant placement.
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
axin 2 (conductin, axil)
, axin-related protein
, axin 2
, Axin-related protein
, axin-like protein
, axis inhibition protein 2