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role in the formation of degradasomes and degradation of beta-catenin (show CTNNB1 Proteins) induced by the TNKSi G007-LK in colorectal cancer cells
AXIN2 overexpression is associated with Breast Cancer Invasion and Metastasis.
the study reveals a strong association of SNPs in the Axin2 gene with lung cancer risk in North Indians.
Genetic variant in AXIN2 gene is associated with gallbladder cancer.
Data show that SS18 (show SS18 Proteins)/SSX (show SSX2 Proteins) tightly regulates the elevated expression of the key Wnt (show WNT2 Proteins) target AXIN2 in primary synovial sarcoma.
our mutation analysis detected already known mutations as well as, to the best of our knowledge, mutations and an interstitial deletion of CTNNB1 (show CTNNB1 Proteins) not described in JAs (show TAP2 Proteins) before. Additionally, a so far unknown transcribed Axin2 splice variant was found, but no further Axin2 mutations.
miR (show MLXIP Proteins)-374a functions as an oncogene (show RAB1A Proteins) in osteosarcoma, and the miR (show MLXIP Proteins)-374a/Axin2 axis might represent a potential therapeutic target for OS intervention.
Flow cytometrically sorted CA9 (show CA9 Proteins)+ population showed increased mRNA level of a Wnt (show WNT2 Proteins) signaling factor AXIN2. In conclusion, these observations indicate that CA9 (show CA9 Proteins) expression in normal crypt base cells has association with intestinal epithelial stemness
Increase in AXIN2 level expression is associated with breast cancer.
rs9675316 located on chr17q23-a24 (show CD164 Proteins) near the AXIN2 gene was the most significantly associated with hallux valgus in males in genome-wide association meta-analyses.
beta-catenin1 cannot revert the ich (show ACE Proteins) phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS (show PITX2 Proteins) domain function.
Axin2 limits Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling resulting from loss of Axin2 leads to progressive myxomatous valve disease.
Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers
Our results reveal a critical role for Axin2 during ocular development, likely by restricting the activity of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis
Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Axin2-expressing prostatic cells express epithelial cell markers and are able to expand cell lineage during prostatic development and maturation.
Axin1 (show AXIN1 Proteins) and Axin2 do not have equivalent functions in satellite cells, but are both involved in repression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.
These data demonstrate a dominant role for Runx2 (show RUNX2 Proteins) in chondrocyte maturation, but implicate Axin2 as an important modulator of the terminal stages of endochondral bone formation.
implants lacking primary stability undergo osseointegration, provided Wnt (show WNT2 Proteins) signalling is amplified. Fibrous encapsulation can be prevented and osseointegration assured if Wnt (show WNT2 Proteins) signalling is elevated at the time of implant placement.
Axin2(-/-) PF-sutures lack physiological endochondral ossification
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
axin 2 (conductin, axil)
, axin-related protein
, axin 2
, Axin-related protein
, axin-like protein
, axis inhibition protein 2