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Defects in GRK1 or GRK7 cause patients to suffer from an inability to properly deactivate rhodopsin leading to problems with recovery and dark adaptation.
Phosphorylation of GRK1 and GRK7 by PKA occurs in the dark, when cAMP levels in photoreceptor cells are elevated.
synthesis of 29 of GRK1 (show GRK1 Proteins) or GRK7 partial peptides that cover the entire sequence of GRK1 (show GRK1 Proteins)/GRK7, to see which interacts with recoverin (show RCVRN Proteins).
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation.
G protein-coupled receptor kinase 7
, G-protein-coupled receptor kinase 7
, g protein-coupled receptor kinase GRK7