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Tat (show TAT ELISA Kits) PTD (show ETS2 ELISA Kits)-Endostatin (show COL18A1 ELISA Kits)-RGD showed high penetration ability through ocular barriers, bound specifically to integrin alpha5beta3 and effectively inhibited the abnormal angiogenesis. Tat (show TAT ELISA Kits) PTD (show ETS2 ELISA Kits)-Endostatin (show COL18A1 ELISA Kits)-RGD represents a potent novel drug applied via eye drops for fundus oculi neovascularization diseases.
The synergy of circulating factor suPAR and APOL1 (show APOL1 ELISA Kits) G1 or G2 on alphavbeta3 integrin activation is a mechanism for CKD.
The authors showed the synergistic negative regulation of the pro-inflammatory cytokine interferon-gamma (show IFNG ELISA Kits) (IFNgamma) and beta3 integrin signaling in murine hematopoietic stem cells function by a novel definitive phenotyping of hematopoietic stem cells.
This study provided evidence in platelets at both static and flow conditions that the calpain cleavage-related sequences of integrin beta3, i.e. T755NITYRGT762, R760GT762, and N756ITY759 participate in bidirectional, outside-in, and inside-out signaling, respectively and the association of c-Src (show SRC ELISA Kits) or kindlin with beta3 integrin may regulate these processes.
By modulating its affinity with kindlin, beta3 integrin may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.
MiR (show MLXIP ELISA Kits)-30a-5p suppresses tumor metastasis of human colorectal cancer by targeting ITGB3.
suppression of beta3-integrin in mice leads to the activation of a neuropilin-1 (NRP1 (show NRP1 ELISA Kits))-dependent cell migration pathway in endothelial cells via a mechanism that depends on NRP1 (show NRP1 ELISA Kits)'s mobilisation away from mature focal adhesions following VEGF (show VEGFA ELISA Kits)-stimulation
Deletion of Itgb3 causes increased B-cell responses to TLR stimulation in vitro.
integrin beta3-mediated signaling in smooth muscle cells links elastin (show ELN ELISA Kits) deficiency and pathological stenosis, and inhibiting this pathway is an attractive therapeutic strategy for supravalvular aortic stenosis.
The clathrin-mediated endocytic machinery combines with Dab2 (show DAB2 ELISA Kits) to facilitate the endocytosis of RGD-integrin-beta3 clusters.
Osteoprotegerin (show TNFRSF11B ELISA Kits) facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3 (show ITGAV ELISA Kits)/FAK (show PTK2 ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling pathway.
The mechanism of resistance of tongue squamous carcinoma cells Cal27 with de novo integrin alphavbeta3 (show ITGAV ELISA Kits) expression to anticancer drugs was studied. In Cal27 cells integrin alphav heterodimers signal through pSrc(Y418) while this is not the case in integrin alphavbeta3 (show ITGAV ELISA Kits)-expressing cells. Overexpression of integrin subunit beta3 gene in Cal27 cells leads to the de novo expression of integrin alphavbeta3 (show ITGAV ELISA Kits) and increased expre...
These findings bring attention to the effects of C-terminal carboxylmethylation on RAB (show HRB ELISA Kits) GTPases and provide a rationale for targeting ICMT (show ICMT ELISA Kits) in the treatment of metastatic cancer
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R (show IGF1R ELISA Kits).
we found a significant cumulative contribution of the genetic heterogeneity of glycoproteins Ia and IIIa and platelet-endothelial cell adhesion molecule-1 (show PECAM1 ELISA Kits) and P-Selectin (show SELP ELISA Kits) genes in the risk of recurrent IVF (show SCN5A ELISA Kits)-ET failures. The coexistence of these SNPs was associated with increased IVF (show SCN5A ELISA Kits)-ET failure risk and the more polymorphic alleles or genotypes were present the higher the risk of IVF (show SCN5A ELISA Kits)-ET failure, especially for younger women
data demonstrate that M. tuberculosis stimulation upregulates integrin alphaVbeta3 (show ITGAV ELISA Kits) expression on monocytes, which upregulates secretion of MMP-1 (show MMP1 ELISA Kits) and -10 on adhesion to the extracellular matrix; this leads to increased monocyte recruitment and collagenase activity, which will drive inflammatory tissue damage
Furthermore, the inside-out activation of GPIIb/IIIa of platelets mediated Streptococcus suis suilysin-induced platelet aggregation.
Findings indicate integrin inhibition as a promising strategy to block both aryl hydrocarbon receptor (AhR (show AHR ELISA Kits)) and transforming growth factor beta (TGF-beta)-controlled features of malignancy in glioblastoma.
Data suggest that the extreme C terminus of kindlin-2 (show FERMT2 ELISA Kits) is essential for interaction with and activation of integrin alphaIIBbeta3; these studies were conducted in macrophage cell line and erythroleukemia cell line.
The observed effects of shear stress on integrin alpha(v (show ITGAV ELISA Kits))beta(3) and p38 MAPK (show MAPK14 ELISA Kits) activation, as well as on FGF-2 (show FGF2 ELISA Kits) release could be mimicked by application of pancreatic elastase to static endothelial cells.
structure and distribution of the CD61 provides insight into the physiological function of the porcine beta(3) integrins and should be of importance in understanding the role of this integrin family in biological processes
Inhibition of integrin alphavbeta3 (show ITGAV ELISA Kits) prevents urokinase plasminogen (show PLG ELISA Kits) activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.
alphavbeta3 integrin engagement in vascular endothelium regulates Ca2 (show CA2 ELISA Kits)+-dependent K+ current
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
, integrin beta3
, integrin beta-3
, platelet gpIIIa
, platelet membrane glycoprotein IIIa
, integrin beta 3 (Cd61)
, beta3 integrin
, glycoprotein GPIIIa
, integrin beta 3
, integrin beta-3 subunit