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Platelets from Dok-1 (show DOK1 ELISA Kits)-/- mice displayed normal aggregation, activation of integrin alphaIIbbeta3, P-selectin (show SELP ELISA Kits) surface expression, and soluble fibrinogen binding. These findings indicate that Dok-1 (show DOK1 ELISA Kits) does not affect "inside-out" platelet signalling.
The integrin Beta3 Pro33 mutation disrupts the localization of 5-HT (show DDC ELISA Kits) transporters to specific compartments within the synapse.
our finding that CD61 is conservative in defining HECs both in vitro for hPSC differentiation and in vivo for mouse embryo provides valuable information on how to define and access the bipotent HECs.
Tat (show TAT ELISA Kits) PTD (show ETS2 ELISA Kits)-Endostatin (show COL18A1 ELISA Kits)-RGD showed high penetration ability through ocular barriers, bound specifically to integrin alpha5beta3 and effectively inhibited the abnormal angiogenesis. Tat (show TAT ELISA Kits) PTD (show ETS2 ELISA Kits)-Endostatin (show COL18A1 ELISA Kits)-RGD represents a potent novel drug applied via eye drops for fundus oculi neovascularization diseases.
The synergy of circulating factor suPAR and APOL1 (show APOL1 ELISA Kits) G1 or G2 on alphavbeta3 integrin activation is a mechanism for CKD.
The authors showed the synergistic negative regulation of the pro-inflammatory cytokine interferon-gamma (show IFNG ELISA Kits) (IFNgamma) and beta3 integrin signaling in murine hematopoietic stem cells function by a novel definitive phenotyping of hematopoietic stem cells.
This study provided evidence in platelets at both static and flow conditions that the calpain cleavage-related sequences of integrin beta3, i.e. T755NITYRGT762, R760GT762, and N756ITY759 participate in bidirectional, outside-in, and inside-out signaling, respectively and the association of c-Src (show SRC ELISA Kits) or kindlin with beta3 integrin may regulate these processes.
By modulating its affinity with kindlin, beta3 integrin may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.
MiR (show MLXIP ELISA Kits)-30a-5p suppresses tumor metastasis of human colorectal cancer by targeting ITGB3.
suppression of beta3-integrin in mice leads to the activation of a neuropilin-1 (NRP1 (show NRP1 ELISA Kits))-dependent cell migration pathway in endothelial cells via a mechanism that depends on NRP1 (show NRP1 ELISA Kits)'s mobilisation away from mature focal adhesions following VEGF (show VEGFA ELISA Kits)-stimulation
Data show that sulfatide promoted integrin alphaV(ITGAV (show ITGAV ELISA Kits)) expression and stimulated integrin alphaVbeta3 (show ITGAV ELISA Kits) clustering and signaling in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) cells.
GpIIIa gene polymorphism was associated with early onset coronary artery disease and increased risk of myocardial infarction.
Data show that FGF2 (show FGF2 ELISA Kits) mutants have potential as anti-angiogenic agents and useful tools for studying the role of integrin alphavbeta3 (show ITGAV ELISA Kits) in FGF2 (show FGF2 ELISA Kits) signalling.
blood platelets have a role in amyloid-beta aggregation in cerebral vessels through integrin alphaIIbbeta3-induced outside-in signaling and clusterin (show CLU ELISA Kits) release
ITGB3 (integrin beta 3 or beta3) is regulated by the Polycomb (show CBX2 ELISA Kits) protein CBX7 (show CBX7 ELISA Kits).
Integrin-beta3 is the major driver for fibronectin (show FN1 ELISA Kits) assembly in cancer-associated fibroblasts, as its inhibition abrogates CAF (show KAT2B ELISA Kits) mediated cancer cell invasion.
Osteoprotegerin (show TNFRSF11B ELISA Kits) facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3 (show ITGAV ELISA Kits)/FAK (show PTK2 ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling pathway.
The mechanism of resistance of tongue squamous carcinoma cells Cal27 with de novo integrin alphavbeta3 (show ITGAV ELISA Kits) expression to anticancer drugs was studied. In Cal27 cells integrin alphav heterodimers signal through pSrc(Y418) while this is not the case in integrin alphavbeta3 (show ITGAV ELISA Kits)-expressing cells. Overexpression of integrin subunit beta3 gene in Cal27 cells leads to the de novo expression of integrin alphavbeta3 (show ITGAV ELISA Kits) and increased expre...
These findings bring attention to the effects of C-terminal carboxylmethylation on RAB (show HRB ELISA Kits) GTPases and provide a rationale for targeting ICMT (show ICMT ELISA Kits) in the treatment of metastatic cancer
The observed effects of shear stress on integrin alpha(v (show ITGAV ELISA Kits))beta(3) and p38 MAPK (show MAPK14 ELISA Kits) activation, as well as on FGF-2 (show FGF2 ELISA Kits) release could be mimicked by application of pancreatic elastase to static endothelial cells.
structure and distribution of the CD61 provides insight into the physiological function of the porcine beta(3) integrins and should be of importance in understanding the role of this integrin family in biological processes
Inhibition of integrin alphavbeta3 (show ITGAV ELISA Kits) prevents urokinase plasminogen (show PLG ELISA Kits) activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.
alphavbeta3 integrin engagement in vascular endothelium regulates Ca2 (show CA2 ELISA Kits)+-dependent K+ current
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
, integrin beta3
, integrin beta-3
, platelet gpIIIa
, platelet membrane glycoprotein IIIa
, integrin beta 3 (Cd61)
, beta3 integrin
, glycoprotein GPIIIa
, integrin beta 3
, integrin beta-3 subunit