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Integrin beta 3 Proteins (ITGB3)
On www.antibodies-online.com are 10 Integrin beta 3 (ITGB3) Proteins from 5 different suppliers available. Additionally we are shipping Integrin beta 3 Antibodies (680) and Integrin beta 3 Kits (24) and many more products for this protein. A total of 729 Integrin beta 3 products are currently listed.
Synonyms:
BDPLT2, BDPLT16, CD61, GP3A, GPIIIA, GT, INGRB3, INTB3, integrin
list all proteins Gene Name GeneID UniProt
ITGB3 16416 O54890
Rat ITGB3 ITGB3 29302  
ITGB3 3690 P05106

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Integrin beta 3 Proteins (ITGB3) by Origin

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More Proteins for Integrin beta 3 Interaction Partners

Mouse (Murine) Integrin beta 3 (ITGB3) interaction partners

  1. This study provided evidence in platelets at both static and flow conditions that the calpain cleavage-related sequences of integrin beta3, i.e. T755NITYRGT762, R760GT762, and N756ITY759 participate in bidirectional, outside-in, and inside-out signaling, respectively and the association of c-Src (show SRC Proteins) or kindlin with beta3 integrin may regulate these processes.

  2. By modulating its affinity with kindlin, beta3 integrin may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.

  3. MiR (show MLXIP Proteins)-30a-5p suppresses tumor metastasis of human colorectal cancer by targeting ITGB3.

  4. suppression of beta3-integrin in mice leads to the activation of a neuropilin-1 (NRP1 (show NRP1 Proteins))-dependent cell migration pathway in endothelial cells via a mechanism that depends on NRP1 (show NRP1 Proteins)'s mobilisation away from mature focal adhesions following VEGF (show VEGFA Proteins)-stimulation

  5. Deletion of Itgb3 causes increased B-cell responses to TLR stimulation in vitro.

  6. integrin beta3-mediated signaling in smooth muscle cells links elastin (show ELN Proteins) deficiency and pathological stenosis, and inhibiting this pathway is an attractive therapeutic strategy for supravalvular aortic stenosis.

  7. The clathrin-mediated endocytic machinery combines with Dab2 (show DAB2 Proteins) to facilitate the endocytosis of RGD-integrin-beta3 clusters.

  8. Integrin beta 3 causes arteriovenous graft occlusion.

  9. Taken together, our results reveal that TD-26 is a novel antithrombotic compound exhibiting both integrin alphaIIbbeta3 inhibition and PI3K signaling blockage, with a low bleeding risk.

  10. Conformational activation of talin by PREL-1 (show APBB1IP Proteins) triggers integrin-mediated cell adhesion.

Human Integrin beta 3 (ITGB3) interaction partners

  1. From these data, we suggest that filamentous vimentin (show VIM Proteins) underneath the plasma membrane is involved in increasing integrin adhesiveness, and thus regulation of the vimentin (show VIM Proteins)-integrin interaction might control cell adhesion

  2. Data suggest that talin increases embedding of integrin-beta-3 (ITGB3) transmembrane domain into lipid bilayer, resulting in activation of integrin-alpha-IIb beta-3 (ITGA2B/ITGB3); phyto-antioxidant EGCG (epigallocatechin gallate) decreases this embedding, thus opposing talin-induced integrin activation. However, EGCG activates ITGA2B/ITGB3 in the absence of talin both in a purified system and in CHO cells.

  3. In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand (show ANGPT2 Proteins) Ang-1 (show ANGPT1 Proteins), but not the receptor binding domain of Ang-2 (show ANGPT2 Proteins), can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK (show MAPK1 Proteins) signaling in the presence of both Ang-1 (show ANGPT1 Proteins) and fibronectin (show FN1 Proteins)

  4. Recombinant platelet membrane glycoprotein IIIa (GPa (show GYPA Proteins)) was successfully obtained and used to establish a Luminex technology-based method for the detection of HPA (show HPSE Proteins)-1a-specific antibodies.

  5. In contrast to HLA-DRB4 (show HLADRB4 Proteins)*01:01P, the inheritance of HLA-DRB3 (show HLA-DRB3 Proteins)*01:01 is strongly associated with the propensity for mounting a humoral immune response against fetal HPA (show HPSE Proteins)-1a antigen.

  6. Case Report: Reduced binding of mutant FLNa (show FLNA Proteins) to beta3 and the facilitated recruitment of talin by beta3 on platelet stimulation, explaining the increased alphaIIbbeta3 activation and the ensuing gain-of-platelet functions.

  7. Data indicate no association of maternal or fetal ITGA2 (show ITGA2 Proteins) C807T SNP, ITGB3 T1565C SNP, PECAM1 (show PECAM1 Proteins) CTG - GTG (show GGT1 Proteins) and SELP (show SEPP1 Proteins) A/C polymorphisms with fetal growth restriction (FGR (show FGR Proteins)).

  8. these results show that differences in stiffness/fluidity due to alphavbeta3 integrin expression or integrin activation by Mn(2+) might not simply be explained by the coupling of integrins to actin via focal adhesions.

  9. These results identify beta3 integrin signaling via repression of BAD as an important survival pathway used by breast cancer cells to evade chemotherapy induced stress.

  10. the contribution of PAR1 (show MARK2 Proteins) and PAR4 (show PAWR Proteins) to thrombin (show F2 Proteins)-mediated activation of the platelet fibrin receptor (GPIIbIIIa), is reported.

Pig (Porcine) Integrin beta 3 (ITGB3) interaction partners

  1. The observed effects of shear stress on integrin alpha(v (show ITGAV Proteins))beta(3) and p38 MAPK (show MAPK14 Proteins) activation, as well as on FGF-2 (show FGF2 Proteins) release could be mimicked by application of pancreatic elastase to static endothelial cells.

  2. structure and distribution of the CD61 provides insight into the physiological function of the porcine beta(3) integrins and should be of importance in understanding the role of this integrin family in biological processes

  3. Inhibition of integrin alphavbeta3 (show ITGAV Proteins) prevents urokinase plasminogen (show PLG Proteins) activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.

Cow (Bovine) Integrin beta 3 (ITGB3) interaction partners

  1. alphavbeta3 integrin engagement in vascular endothelium regulates Ca2 (show CA2 Proteins)+-dependent K+ current

  2. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

Integrin beta 3 (ITGB3) Protein Profile

Protein Summary

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

Alternative names and synonyms associated with Integrin beta 3 (ITGB3)

  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3)
  • integrin beta 3 (Itgb3)
  • integrin, beta 3 (Itgb3)
  • BDPLT2 protein
  • BDPLT16 protein
  • CD61 protein
  • GP3A protein
  • GPIIIA protein
  • GT protein
  • INGRB3 protein
  • INTB3 protein
  • integrin protein

Protein level used designations for Integrin beta 3 Proteins (ITGB3)

integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) , integrin beta3 , GPIIIa , integrin beta-3 , platelet gpIIIa , platelet membrane glycoprotein IIIa , integrin beta 3 (Cd61) , beta3 integrin , glycoprotein GPIIIa , integrin beta 3 , integrin beta-3 subunit

GENE ID SPECIES
100423047 Ovis aries
16416 Mus musculus
29302 Rattus norvegicus
3690 Homo sapiens
397063 Sus scrofa
282642 Bos taurus
374209 Gallus gallus
403788 Canis lupus familiaris
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