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lysine-specific demethylase (show MBD2 ELISA Kits)-1 is an important oncogene (show RAB1A ELISA Kits) in gastric cancer, and lysine-specific demethylase (show MBD2 ELISA Kits)-1-mediated epigenetic repression of KLF2 (show KLF2 ELISA Kits) plays a critical role in gastric cancer development and progression.
The data indicate that LSD1 acts as an epigenetic regulator of epithelial-mesenchymal transition and contributes to the metastasis of ovarian cancer.
We also uncovered the suppression of the p53 (show TP53 ELISA Kits) signaling pathway that mediated the activity of USP7 (show USP7 ELISA Kits) and LSD1. Furthermore, USP7 (show USP7 ELISA Kits) and LSD1 expression levels were higher in the 150 glioma patients than these levels in normal brain tissues and were correlated with glioma progression.
LSD1 knockdown affected the fuction of gastric cancer MKN-28 cell line.
our findings showed that miR (show MLXIP ELISA Kits)-708 might serve as an antioncogene by directly targeting LSD1, through promoting cell growth and cell invasion.
Data show that lysine-specific demethylase (show MBD2 ELISA Kits) 1 (LSD1) is a drug target for mixed lineage leukemia (MLL (show MLL ELISA Kits))-rearranged leukemia, and LSD1 inhibitors are potential therapeutics for the malignancy.
Results show that LSD1 is upregulated in human prostate cancer and plays an oncogenic role.
Authors found positive correlations between LSD1 expression and other proteins: epithelial-mesenchymal transition markers, C-myc (show MYC ELISA Kits) and cyclin (show PCNA ELISA Kits)-related proteins. Inhibiting LSD1 expression in vitro impaired the proliferation and invasiveness of GBC cells and also downregulated c-myc (show MYC ELISA Kits) expression and consequently inhibited GBC cell proliferation.
These results highlight a novel mechanism regulating LSD1 expression and identify LSD1 as a promising therapeutic target for treating metastatic ovarian cancer driven by EGF (show EGF ELISA Kits) signaling.
these data suggest that KDM1A likely contains a histone H3 (show HIST3H3 ELISA Kits) secondary specificity element on the enzyme surface that contributes significantly to its recognition of substrates and products.
RIP140 protects LSD1's catalytic domain and antagonizes its Jade-2-mediated ubiquitination and degradation.
Loss of maternal LSD1/KDM1A in mice results in embryonic arrest at the 1-2 cell stage, with arrested embryos failing to undergo the maternal-to-zygotic transition.
KDM1A plays critical roles in establishing the correct epigenetic landscape of the zygote upon fertilization, in preserving genome integrity and in initiating new patterns of genome expression that drive early mouse development.
Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA ELISA Kits)) directly regulates Kruppel-like factor 4 (Klf4 (show KLF4 ELISA Kits)) expression and increasing the levels of histone demethylase (show MBD2 ELISA Kits) Lsd1 and transcription factor Brd4 (show BRD4 ELISA Kits) in B cell.
Deletion or reduction of isoform neuro LSD1 translates into decreased levels of activating histone marks at egr1 and c-fos promoters, dampening their psychosocial stress-induced transcription and resulting in low anxiety-like behavior.
Rcor2 (show Rcor2 ELISA Kits), a co-repressor of LSD1, controls neurogenesis in the developing mouse brain.
GFI1 (show ZNF163 ELISA Kits) proteins recruit the chromatin-modifying protein LSD1, a member of the CoREST (show Rcor2 ELISA Kits) repressive complex, to epigenetically silence the endothelial program in haemogenic endothelium and allow the emergence of blood cells
LSD1 is essential for oocyte meiotic progression by upregulating CDC25B (show CDC25B ELISA Kits) expression.
This study described how neuronal activity controls the neurospecific splicing of the epigenetic co-repressor LSD1 in mammalian nervous system.
LSD1 mediates erythroid differentiation, via epigenetic modification of the GATA-2 (show GATA2 ELISA Kits) locus.
LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss.
results suggest that the LSD1-dependent shutdown of Etv2 gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase (show MBD2 ELISA Kits) activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
LSD1, EDS1, and PAD4 (show PADI4 ELISA Kits) participate in the regulation of various molecular and physiological processes that influence Arabidopsis fitness.
AtSWP1 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.
AtLSD1, similar to HsLSD1, has demethylase (show MBD2 ELISA Kits) activity toward mono- and dimethylated Lys4 but not dimethylated Lys9 and Lys27 of histone 3. [LSD1]
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
amine oxidase (flavin containing) domain 2
, lysine (K)-specific demethylase 1
, lysine (K)-specific demethylase 1A
, BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, flavin-containing amine oxidase domain-containing protein 2
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3