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Data show that double mutation of follicle-stimulating hormone receptor (fshr (show FSHR ELISA Kits)) and luteinizing hormone receptor (lhcgr) resulted in infertile males
Data show for the first time in a vertebrate species that Leydig cells as well as Sertoli cells express the mRNAs for both fshr (show FSHR ELISA Kits) and lhcgr.
suggest that upregulation of NG2/CSPG4 (show MCSP ELISA Kits) rather than changes in CD44 (show CD44 ELISA Kits) or Ki-67 (show MKI67 ELISA Kits) expression is associated with low overall survival in glioblastoma multiforme patients, supporting NG2/CSPG4 (show MCSP ELISA Kits) as a potential prognostic marker in glioblastoma
Suggest that CD44 (show CD44 ELISA Kits)-positivity might be a candidate tumor stem cell marker in intrahepatic cholangiocarcinoma and a prognostic indicator.
Mechanistically, CD44v interacts with and stabilizes xCT (show SLC7A11 ELISA Kits) and thereby promotes the uptake of cysteine for glutathione synthesis and stimulates side-population cell enrichment.
These tumor samples express CD44 (show CD44 ELISA Kits) protein at low rather than high levels. There is no correlation between CLDN3 (show CLDN3 ELISA Kits) gene expression and protein expression in these CPTAC samples; hence, the claudin-low subtype defined by gene expression is not the same group of tumors as that defined by low expression of CLDN3 (show CLDN3 ELISA Kits) protein.
this study shows that genkwadaphnin promotes leukocyte migration by increasing CD44 (show CD44 ELISA Kits) expression via PKD1 (show PKD1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signaling pathway
High CD44 (show CD44 ELISA Kits) expression is associated with high grade glioma.
CNS disease was associated with enhanced expression of cytoplasmic and membranous ITGA10 and nuclear PTEN (P < 0.0005, P = 0.002, P = 0.024, respectively). sCNSL presented decreased membranous CD44 (show CD44 ELISA Kits) and nuclear and cytoplasmic cadherin-11 expressions (P = 0.001, P = 0.006, P = 0.048, respectively). In PCNSL lactoferrin (show LTF ELISA Kits) expression was upregulated (P < 0.0005).
In clinical specimens of breast cancer, authors established that the expression of CD44s and HAS2 (show HAS2 ELISA Kits) was positively correlated. Results establish a positive feedback mechanism that sustains PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling in tumor cells, further illuminating the nearly universal role of this pathway in cancer cell survival.
In regulation of tumour cells with high CD44 (show CD44 ELISA Kits) expression.
ZEB1 (show ZEB1 ELISA Kits)-induced epithelial-to-mesenchymal transition and associated molecular changes in ESRP1 (show ESRP1 ELISA Kits) and CD44 (show CD44 ELISA Kits) contribute to early pathogenesis and metastatic potential in established lung cancer
Study tested for the first time a role of ZFP36L2 (show ZFP36L2 ELISA Kits) in the decay of LHR mRNA, when transcription was inhibited; results of our cell-based assay support the conclusion that LHR mRNA expression is controlled post-transcriptionally by ZFP36L2 (show ZFP36L2 ELISA Kits).
FSHR (show FSHR ELISA Kits) and LHR proteins are significantly upregulated in CCs (show CCS ELISA Kits) surrounding oocytes arrested at the 2-cell stage, reflecting their developmental incompetence.
Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1 (show ESR1 ELISA Kits), LHR, and FSHR (show FSHR ELISA Kits)
Data suggest that persistent cAMP signals from internalized luteinizing hormone receptor (LH receptors) contribute to transmitting LH effects inside follicle cells and ultimately to the oocyte.
Demonstrate the presence of LH receptors. Activation resulted in a dose-dependent increase in glucose-induced release of insulin (show INS ELISA Kits).
LHCGR signaling in regulating the Ahr (show AHR ELISA Kits) message involves protein kinase A pathway and is attributable to decreased transcription rate.
Data from mutant mouse strain (gain-of-function mutation in LHR, D578G; most common mutation found in familial male-limited precocious puberty) confirm that LHR is critical for male steroidogenesis, gametogenesis, and Leydig cell development.
LH/hCG (show CGA ELISA Kits) tightly up-regulates MKP-3 (show DUSP6 ELISA Kits) which in turn, dephosphorylates ERK1/2 (show MAPK1/3 ELISA Kits) and drives p21 expression.
Data suggest that Lhcgr in endometrium and luteinizing hormone in blastocyst are involved in embryo/blastocyst implantation; expression of Lhcgr is up-regulated in endometrial epithelium in estrus cycle at time of implantation readiness (estrus).
Through the LHR, LH/hCG (show CGA ELISA Kits) tightly regulates MKP-2 (show DUSP4 ELISA Kits) expression, which modulates the induction of CYP11A1 (show CYP11A1 ELISA Kits) by 8Br-cAMP.
The outcomes of the present study support a dynamic multi-facetted regulation of LHR during pre-translation.
expression of LHR mRNA in bovine granulosa cells is established after follicle deviation, and the lower abundance of LRBP (show MVK ELISA Kits) mRNA after the expected time of deviation may contribute to greater expression of LHR in the bovine dominant follicle
These results suggested an acute regulation of INSL3 (show INSL3 ELISA Kits) by luteinizing hormone (LH) because INSL3 (show INSL3 ELISA Kits) concentrations increased immediately after endogenous and exogenous LH stimulation.
INVESTIGATION OF STAT5A (show STAT5A ELISA Kits), FSHR (show FSHR ELISA Kits) AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
These findings strongly support the concept that IGF-1 (show IGF1 ELISA Kits) upregulates LHR expression in granulosa cells and that IGF-1 (show IGF1 ELISA Kits) is required for determining which follicle becomes dominant and acquires ovulatory capacity.
LHCGR mRNA expression in granulosa cells was significantly higher in large antral follicles than in cysts, and not detected in granulosa cells of small and medium antral follicles.
The luteinizing hormone receptor [LHR] splicing pattern is complex in bovine Leydig cells, and expression of full-length LHR and isoforms A and B changes when induced with LH.
The LHCGR gene is a potential marker for superovulation response and can be used to predict the most appropriate dose of FSH (show BRD2 ELISA Kits) for superovulation in Chinese Holstein cows.
Dominant follicles experience a reduction in FSH (show BRD2 ELISA Kits) dependence (diminished expression of FSHR (show FSHR ELISA Kits)), but acquire increased LH dependence (enhanced expression of LHCGR) as they grow during the low FSH (show BRD2 ELISA Kits) milieu of follicular waves.
Three single nucleotide polymorphisms in LHCGR were significantly associated with variations in cattle fertility and production traits.
In porcine ovaries, MAb found 6 distinct LHR bands migrating at approximately 92, 80, 68, 59, 52 & 48 kDa. There is a possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders & Alzheimer's disease.
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia.
luteinizing hormone receptor
, lutropin-choriogonadotropic hormone receptor
, luteinizing hormone/choriogonadotropin receptor
, lutropin-choriogonadotropic hormone receptor-like
, Lutropin-choriogonadotropic hormone receptor
, CD44 antigen
, GP90 lymphocyte homing/adhesion receptor
, Hermes antigen
, cell surface glycoprotein CD44
, chondroitin sulfate proteoglycan 8
, extracellular matrix receptor III
, hematopoietic cell E- and L-selectin ligand
, heparan sulfate proteoglycan
, homing function and Indian blood group system
, hyaluronate receptor
, phagocytic glycoprotein 1
, hypergonadotropic hypogonadism
, lutropin/choriogonadotropin receptor
, LH receptor
, luteinizing hormone receptor 2 protein
, luteinizing hormone receptor precursor variant 1
, luteinizing hormone receptor precursor variant 2
, lutropin-choriogonadotropin receptor