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These findings suggest that CADM1 expression is a novel prognostic factor for peripheral T cell lymphoma, not otherwise specified
miR (show MLXIP ELISA Kits)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1, and an inverse correlation between miR (show MLXIP ELISA Kits)-21 and CADM1 expression in vivo. MiR (show MLXIP ELISA Kits)-21 overexpression is attributed to MYCN (show MYCN ELISA Kits)-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer
We conclude that CADM1 was not associated with cell-cell interaction between lymphoma cells and macrophages, although CADM1 may be a useful marker of ATLL for diagnostic procedures.
miR (show MLXIP ELISA Kits)-21 overexpression promotes cardiac fibrosis via STAT3 (show STAT3 ELISA Kits) signaling pathway by decrease CADM1 expression, indicating miR (show MLXIP ELISA Kits)-21 as an important signaling molecule for cardiac fibrotic remodeling and atrial fibrillation.
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (show LYST ELISA Kits) (cg16962115, FDR = 1.24E-04), CADM1 (cg21933078, FDR = 1.22E-02) and NFATC1 (show NFATC1 ELISA Kits) (cg06784563, FDR = 1.46E-02)
CADM1 mRNA expression was highly upregulated in normal tissues compared to esophageal squamous cell carcinoma tissues, indicating that the loss of CADM1 expression influenced the pathogenesis, invasion, and metastasis of ESCC.
Eight and five of the nine samples were negative for cell adhesion molecule 1 and Osterix (show SP7 ELISA Kits) respectively. The other markers showed no statistical significance(CD151 (show CD151 ELISA Kits),ALP (show ALP ELISA Kits)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 could be a useful marker for identifying this phenomenon in carcinoma tissues
Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re...
High expression of CADM1 on most HTLV-1-infected cells in the face of enhanced cytotoxic T lymphocyte counterselection implies that CADM1 confers a strong benefit on the virus.
Decreased expression of TSLC1 is associated with the differentiation in ovarian epithelial cancer. TSLC1 might be used as a molecular marker of severity in early stage ovarian cancer, and to help differentiating benign and malignant ovarian tumors.
NF-kB mediated upregulation of CADM1 was identified as a mechanism of TNFalpha (show TNF ELISA Kits) induced migration.
The results of this study demonstrate that the synapse-organizing adhesion molecule (show NCAM1 ELISA Kits) SynCAM 1 has pronounced effects on neuronal connectivity in the hippocampal CA3 (show CA3 ELISA Kits) area.
Cadm1 is a direct target of NFATc1 (show NFATC1 ELISA Kits), which is induced by RANKL (show TNFSF11 ELISA Kits) through epigenetic modification, and regulates osteoclastic bone resorption in a negative feedback manner.
Data show that cell adhesion molecule 1 (SynCAM 1) generally prolongs the lifetime of spines.
This experiments show that the survival rate of adult-generated neurons is increased by overexpressing SynCAM 1
Our study reveals a novel mechanism of chronic NF-kappaB (show NFKB1 ELISA Kits) activation by CADM1 in HTLV-1 infected cells
Study demonstrates that polysialic acid-SynCAM 1 defines a subpopulation of NG2 (show Vcan ELISA Kits) cells and identifies the presence of polysialic acid-NRP2 (show NRP2 ELISA Kits) in microglia
CADM1 appeared to sustain gap junctional intercellular communication among alpha-cells via homophilic binding and, based on this action, CADM1 appears to prevent excessive secretion of glucagon (show GCG ELISA Kits) from alpha-cells.
This study demonistrated that SynCAM 1 in the synaptic organization of the rod visual pathway and provide evidence for novel roles of synaptic adhesion in the structural and functional integrity of ribbon synapses.
Necl-2 co-localizes with ErbB4 (show ERBB4 ELISA Kits) in hippocampus and and regulates ErbB4 (show ERBB4 ELISA Kits) signaling in cultured neurons.
Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
, TSLC1/Nectin-like 2/IGSF4
, immunoglobulin superfamily member 4
, immunoglobulin superfamily, member 4
, immunoglobulin superfamily, member 4D variant 1
, immunoglobulin superfamily, member 4D variant 2
, nectin-like 2
, nectin-like protein 2
, spermatogenic immunoglobulin superfamily
, synaptic cell adhesion molecule
, truncated CADM1 protein
, tumor suppressor in lung cancer 1
, cell adhesion molecule 1
, cell adhesion molecule 1 transcript variant 8abc
, immunoglobulin superfamily member 4A
, immunosuperfamily protein Bl2
, immunoglobulin superfamily, member 4A
, secretory isoform of TSLC1
, tumor suppressor in lung cell-1