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Browse our CD45 Proteins (PTPRC)

Full name:
Protein tyrosine Phosphatase, Receptor Type, C Proteins (PTPRC)
On www.antibodies-online.com are 34 Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) Proteins from 12 different suppliers available. Additionally we are shipping CD45 Antibodies (2478) and CD45 Kits (15) and many more products for this protein. A total of 2536 CD45 products are currently listed.
Synonyms:
B220, cd45, CD45R, GP180, L-CA, Lca, loc, Ly-5, LY5, Lyt-4, PTPRC, RT7, si:dkeyp-47c5.1, T200
list all proteins Gene Name GeneID UniProt
PTPRC 5788 P08575
PTPRC 19264  
PTPRC 24699 P04157

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CD45 Proteins (PTPRC) by Origin

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Top referenced CD45 Proteins

  1. Human CD45 Protein expressed in Human Cells - ABIN2002039 : Justement, Campbell, Chien, Cambier: Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. in Science (New York, N.Y.) 1991 (PubMed)
    Show all 6 references for ABIN2002039

More Proteins for CD45 Interaction Partners

Human Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) interaction partners

  1. Use of the common leukocyte marker CD45 increases the sensitivity of the diagnosis of lymphocytic myocarditis.

  2. Review/Meta-analysis: Rheumatoid arthritis patients with PTPRC rs10919563 A allele show a poor response to anti-TNF (show TNF Proteins) therapy.

  3. Data suggest that CD41 and CD45 expression marked the onset of haemangioblastoma (HB) neovascularisation and the stepwise development of the angioformative period, and also the underlying therapeutic targets of anti-vascular treatment.

  4. PTPRC has become the most replicated genetic biomarker of response to TNF (show TNF Proteins) inhibitors

  5. CD45RO+ memory T-cells produce IL-17 (show IL17A Proteins) in patients with atherosclerosis.

  6. Data show the structural basis for, and the potent signaling effects of, local CD45 antigen and kinase segregation.

  7. a CD45+/CD19 (show CD19 Proteins) - cell population in bone marrow aspirates correlated with the clinical outcome of patients with mantle cell lymphoma.

  8. High CD45 expression is associated with multiple myeloma.

  9. C77G T(reg (show EXTL3 Proteins)) showed diminished upregulation of activation markers, lower phosphorylation of p56(lck (show LCK Proteins))(Y505) and a reduced proliferative potential when stimulated with anti-TcR or anti-TcR plus CD28 (show CD28 Proteins) mAb suggesting decreased responsiveness to activating stimuli. Data suggest that the changes in CD45 isoform combination resulting from the C77G mutation alter the responsiveness

  10. Findings indicate that CD45 antigen(+) and c-Kit protein(+) hematopoietic cells were more abundant in muscle than in bone marrow between embryonic 14.5 and 17.5 days.

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) interaction partners

  1. Increased numbers of CD4 (show CD4 Proteins)(+)CD45RA(-)FoxP3 (show FOXP3 Proteins)(low) cells may cause an imbalance between Treg and Th17 cells that is mainly localized to the colon.

  2. Use of the common leukocyte marker CD45 increases the sensitivity of the diagnosis of lymphocytic myocarditis.

  3. Aging induces loss of stemness with concomitant gain of myogenic properties of a pure population of CD34 (show CD34 Proteins)+/CD45- muscle derived stem cells.

  4. deletion of Pten in CD45-expressing cells induces development of T-cell acute lymphoblastic leukemia and lymphoma, but not other hematologic malignancies

  5. A noncatalytic role for CD45 in regulating tonic, but not antigen-mediated, B-cell antigen receptor (BCR (show BCR Proteins)) signaling through modulation of the function of the inhibitory coreceptor CD22 (show CD22 Proteins), was identified.

  6. CD45 ligation specifically reduced Treg motility in an integrin-dependent manner, resulting in enhanced interactions between Tregs and DCs in vivo.

  7. Data (including data from genome-wide mutagenesis studies) suggest that nonsense mutation in Ptprc is a susceptibility trait for herpes simplex encephalitis due to Herpesvirus 1; this effect appears to be mediated by Th1 (show HAND1 Proteins) cells and the brain stem.

  8. These findings demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation and suggest that innate immune cells may communicate with stromal cells to regulate IL-7 (show IL7 Proteins) production.

  9. Expressing CD45 promoters containing these regions and tethered to green fluorescent protein (GFP) in a primary B-cell differentiation assay and a transplantation model resulted in high levels of GFP in lymphoid, myeloid, and nucleated erythroid cells

  10. identified a novel CD45 phosphorylation event in hematopoietic progenitor cells that correlated with motile response and governed by the chemotactic factor CXCL12 (show CXCL12 Proteins)

CD45 (PTPRC) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Alternative names and synonyms associated with CD45 (PTPRC)

  • protein tyrosine phosphatase, receptor type, C (PTPRC)
  • protein tyrosine phosphatase, receptor type, C (ptprc)
  • protein tyrosine phosphatase, receptor type, C (Ptprc)
  • B220 protein
  • cd45 protein
  • CD45R protein
  • GP180 protein
  • L-CA protein
  • Lca protein
  • loc protein
  • Ly-5 protein
  • LY5 protein
  • Lyt-4 protein
  • PTPRC protein
  • RT7 protein
  • si:dkeyp-47c5.1 protein
  • T200 protein

Protein level used designations for PTPRC

receptor-type tyrosine-protein phosphatase C , leukocyte common antigen, CD45 , protein tyrosine phosphatase, receptor type, C , CD45 antigen , leukocyte common antigen , receptor-type tyrosine-protein phosphatase C-like , T200 glycoprotein , T200 leukocyte common antigen , protein tyrosine phosphatase, receptor type, c polypeptide , lymphocyte antigen 5 , lymphocyte common antigen , Protein tyrosine phosphatase, receptor-type, c polypeptide , leucocyte common antigen , leukocyte common antigen A , leukocyte common antigen B , membrane tyrosine phosphatase

GENE ID SPECIES
386580 Gallus gallus
457607 Pan troglodytes
490255 Canis lupus familiaris
559154 Danio rerio
100026890 Monodelphis domestica
100061950 Equus caballus
100074271 Ornithorhynchus anatinus
100358807 Oryctolagus cuniculus
100446144 Pongo abelii
100474611 Ailuropoda melanoleuca
100522631 Sus scrofa
100546661 Meleagris gallopavo
5788 Homo sapiens
19264 Mus musculus
24699 Rattus norvegicus
407152 Bos taurus
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