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Browse our F2RL1 Proteins (F2RL1)

Full name:
Coagulation Factor II (thrombin) Receptor-Like 1 Proteins (F2RL1)
On are 7 Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Proteins from 2 different suppliers available. Additionally we are shipping F2RL1 Kits (30) and F2RL1 Antibodies (28) and many more products for this protein. A total of 71 F2RL1 products are currently listed.
Gpcr11, GPR11, Par-2, Par2
list all proteins Gene Name GeneID UniProt
F2RL1 2150 P55085
F2RL1 14063 P55086
Rat F2RL1 F2RL1 116677 Q63645

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F2RL1 Proteins (F2RL1) by Origin

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More Proteins for F2RL1 Interaction Partners

Human Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. Study suggests that deregulated pericellular matriptase (show ST14 Proteins) activity in OSCC may transactivate PAR-2 on fibroblasts in the surrounding tissue and thus promote their recruitment to the perimeter of the tumor, contributing to a microenvironement that favors tumor growth of oral squamous cell carcinoma.

  2. Study demonstrates that AHRR (show CYP1A1 Proteins) and F2RL3 (show F2RL3 Proteins) methylation are strong predictors individually for lung cancer development.

  3. PAR2 activation promoted obesity.

  4. Data suggest that thrombin (show F2 Proteins) can directly activate PAR2 vasorelaxation, signal transduction (stimulating both calcium and MAP kinase (show MAPK1 Proteins) responses), and triggering beta-arrestin recruitment (both beta-arrestin 1 (show ARRB1 Proteins) and 2).

  5. Activation of PAR-2 by SLIGRL, a PAR-2 specific ligand, leads to dual phosphorylation of both catalytic sites but primarily regulated eNOS (show NOS3 Proteins)-Thr (show TRH Proteins)-495 phosphorylation with no change in nitric oxide production.

  6. Stimulation of PAR-2 activates Nf-kappaB (show NFKB1 Proteins) signaling, resulting in RelA (show NFkBP65 Proteins) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.

  7. This study provides evidence for the major role of PAR-2 in the pathogenesis of gastroesophageal reflux disease (GERD) and GERD-associated mucosal alterations.

  8. PAR-2 expression is increased on CD14 (show NDUFA2 Proteins)++CD16 (show CD16 Proteins)+ monocytes in the peripheral blood of subjects with severe asthma and may be a biomarker of asthma severity.

  9. PAR-2 contributes to the progression of pulmonary fibrosis, and targeting PAR-2 may be a promising therapeutic strategy for treating pulmonary fibrosis.

  10. Binding of the PH domain of PAR-2 enables breast cancer growth and extravillous trophoblast invasion.

Mouse (Murine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. The levels of miR (show MLXIP Proteins)-223, miR (show MLXIP Proteins)-339 and miR (show MLXIP Proteins)-21, which are associated with platelet activation, were elevated in pooled mouse plasma exosomes before thrombosis and enriched in thrombin (show F2 Proteins)-stimulated platelet-derived exosomes in vitro.

  2. Neutrophil elastase (show ELANE Proteins) induced acute inflammation and pain in knee joints of mice. These changes are PAR2-dependent and appear to involve activation of a p44 (show GTF2H4 Proteins)/42 MAPK (show MAPK1 Proteins) pathway. Blocking neutrophil elastase (show ELANE Proteins), PAR2 and p44 (show GTF2H4 Proteins)/42 MAPK (show MAPK1 Proteins) activity can reduce inflammation and pain, suggesting their utility as therapeutic targets.

  3. Reductions in astrogliosis, inflammation and neuromotor recovery observed in protease Activated Receptor 2 knockout mice after spinal cord injury suggests that this receptor and its agonists represent new drug targets to foster neuromotor recovery.

  4. Stimulation of PAR-2 activates Nf-kappaB (show NFKB1 Proteins) signaling, resulting in RelA (show NFkBP65 Proteins) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.

  5. Tryptase (show TPSAB1 Proteins) and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin (show OVA Proteins)-induced atopic-like dermatitis

  6. This study reveals, for the first time, an important role for PAR2 in allergic lung inflammation

  7. HAI-1 (show SPINT1 Proteins) may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2-dependent p38 mitogen-activated protein kinase (show MAPK14 Proteins) signaling.

  8. PAR2 activation through endogenous mast cell tryptase activity could be required, at least partially, to mediate CCL11-induced eosinophil migration

  9. These studies identify the thrombin receptor (show F2R Proteins) as a powerful extracellular regulatory switch that could be readily targeted to improve myelin production in the face of white matter injury and disease.

  10. PAR2 knockout prevented bone cancer-related pain behaviours and associated neurochemical changes in dorsal root ganglion and dorsal horn.

Cow (Bovine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. PAR1 and PAR2 regulate endothelial NO synthase phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

F2RL1 Protein Profile

Protein Summary

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

Alternative names and synonyms associated with F2RL1

  • Proteinase-activated receptor 2 (par2)
  • coagulation factor II (thrombin) receptor-like 1 (F2RL1)
  • coagulation factor II (thrombin) receptor-like 1 (F2rl1)
  • Gpcr11 protein
  • GPR11 protein
  • Par-2 protein
  • Par2 protein

Protein level used designations for F2RL1

Proteinase-activated receptor 2 , G-protein coupled receptor 11 , coagulation factor II receptor-like 1 , protease-activated receptor 2 , proteinase-activated receptor 2 , thrombin receptor-like 1 , Protease-activated receptor-2 , proteinase-activated receptor-2 , Proteinase-activated receptor-2 G protein-coupled receptor 11 , Proteinase-activated receptor-2, G protein-coupled receptor 11 , PAR-2

100195488 Salmo salar
2150 Homo sapiens
14063 Mus musculus
116677 Rattus norvegicus
526525 Bos taurus
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