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analysis of the JAK (show JAK3 ELISA Kits)-Fes-phospholipase D (show PLD ELISA Kits) signaling pathway that is enhanced in highly proliferative breast cancer cells
c-fes gene expression was found in myeloid leukemias, whereas low or no expression in lymphocytic leukemias.
FES kinase is a mediator of wild-type KIT signalling implicated in cell migration.
Closing in on the biological functions of Fps/Fes and Fer. A review.
Fes naturally adopts an inactive conformation in vivo, and maintenance of the inactive structure requires the coiled-coil and SH2 domains.
Fps/Fes and Fer are expressed in human and mouse platelets, and are activated following stimulation with collagen and collagen-related peptide (CRP (show CRP ELISA Kits)), suggesting a role in GPVI (show GP6 ELISA Kits) receptor signaling
Fes transduces inductive signals for terminal macrophage and granulocyte differentiation, and this biological activity is mediated through the activation of lineage-specific transcription factors.
FPS (show FDPS ELISA Kits) mediates enhanced sensitization to VEGF (show VEGFA ELISA Kits) and PDGF (show PDGFA ELISA Kits) signaling in ECs; this hypersensitization contributes to excessive angiogenic signaling and underlies the observed hypervascular phenotype of human myristoylated FPS (show FDPS ELISA Kits) expressed in transgenic mice.
c-Fes is a regulator of the tubulin (show TUBB ELISA Kits) cytoskeleton and may contribute to Fes-induced morphological changes in myeloid hematopoietic and neuronal cells
NMR assignment of the SH2 domain
FES is a driver of melanoma progression in a mouse model.
Fes inhibition might provide therapeutic benefits in breast cancer, in part by attenuating tumor-associated angiogenesis and the metastasis-promoting functions of tumor-associated macrophages.
Fes protein is activated downstream of activated Kit receptor, and this is facilitated by the Fes SH2 domain binding to Kit, and by trans-phosphorylation by Fyn (show FYN ELISA Kits) kinase.
Truncation of c-fes via gene targeting results in embryonic lethality and hyperproliferation of hematopoietic cells.
Fes was expressed in mouse brain. Experiments with transfected mouse cDNA show that Fes links Sema3A (show SEMA3A ELISA Kits) signals to CRMP-CRAM (show DPYSL5 ELISA Kits).
Fes may be a key component of the granulocyte differentiation machinery, may regulate granulocyte-specific gene expression
Hematopoiesis is deregulated in the absence of Fps and Fer kinases. Qualitative differences in myeloid colonies from compound mutant mice suggested a role for Fps and Fer kinases in regulating cell-cell adhesion or a skewing in cellularity of colonies.
Fps/Fes may act synergistically with Flk1 (show KDR ELISA Kits) to modulate hemangioblast differentiation into the endothelium.
plays a critical role in microtubule dynamics including microtubule nucleation and bundling through its FCH (show FECH ELISA Kits) domain
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.
Oncogene FES, feline sarcoma virus
, feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
, feline sarcoma/Fujinami avian sarcoma oncogene homolog
, proto-oncogene c-Fes
, proto-oncogene c-Fps
, proto-oncogene tyrosine-protein kinase Fes/Fps
, tyrosine-protein kinase Fes/Fps
, V-FES feline sarcoma viral/V-FPS fujinami avian sarcoma viral oncogene homolog
, c-fes proto-oncogene protein
, feline sarcoma viral (v-fes) oncogene
, v-fps oncogene homolog
, tyrosine kinase Fps/Fes
, feline sarcoma oncogene
, c-fps proto oncogene
, tyrosine-protein kinase Fes/Fps-like