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findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 (show MYD88 ELISA Kits) signaling and sustaining epidermal barrier function
The results contradict the model of feedback activation of Rab5 (show RAB5A ELISA Kits) and instead indicate that Rbpt5 is recruited by both Rabex5 recognizing ubiquitylated cargo and by Rab4 (show RAB4A ELISA Kits) to activate Rab5 (show RAB5A ELISA Kits) in a feed-forward manner.
RABEX-5 is a potential useful indicator and predicts a poor long-term prognosis for small cell lung cancer(SCLC), which should be considered in defining the prognosis with other well-known prognosticators in C-SCLC patients
Expression of RABEX-5 is significantly higher in gastric cancer tissues and is associated with tumor size and lymph node metastasis.
analysis of Rabex-5 GEF activation by Rabaptin-5 (show RABEP1 ELISA Kits)
This implies that Rap (show LRPAP1 ELISA Kits) regulates endothelial barrier function by dual control of cytoskeletal tension. The molecular details of the signaling pathways are becoming to be elucidated
RABEX-5 mRNA expression is a strong predictor of poor prognosis in prostate cancer patients treated by radical prostatectomy.
Interaction of Rabex-5 with Rab5 (show RAB5A ELISA Kits) depends on interaction of the MIU domain with the ubiquitinated L1 to drive its internalization.
KCa2.3 (show KCNN3 ELISA Kits) is localized to a caveolin-rich domain within the plasma membrane and is endocytosed in a dynamin (show DNM1 ELISA Kits)- and Rab5 (show RAB5A ELISA Kits)-dependent manner.
a novel mechanistic insight into how Rabex-5 regulates internalization and postendocytic trafficking of ubiquitinated L1 destined for lysosomal degradation.
Knockdown of RABEX-5 also inhibited wound healing, migration and the invasive abilities of gastric cancer cells.
Hyperinsulinemia induced insulin (show INS ELISA Kits) resistance in 3T3-L1 adipocytes by retaining GLUT4 (show SLC2A4 ELISA Kits) in a Rab5 (show RAB5A ELISA Kits)-activity-dependent compartment.
Kruppel-like factor 5 (show KLF5 ELISA Kits) is indispensable for adhesion, homing, lodging and retention of haematopoietic stem cells and progenitors in the bone marrow through Rab5 (show RAB5A ELISA Kits)-dependent post-translational regulation of beta1/beta2 integrins
Rab5 (show RAB5A ELISA Kits) is required for phagocytosis of heat-inactivated Pseudomonas aeruginosa by macrophages.
Rabex-5 regulates neurite morphogenesis of hippocampal neurons by activating at least two downstream targets, Rab5 (show RAB5A ELISA Kits), which is localized in both axons and dendrites, and Rab17 (show RAB17 ELISA Kits), which is localized in dendrites alone
Data show that RabGEF1 can negatively regulate thymic stromal lymphopoietin (TSLP (show TSLP ELISA Kits)) production in vivo and that excessive production of TSLP (show TSLP ELISA Kits) contributes to many of the phenotypic abnormalities in Rabgef1-/- mice.
Data reveal the affinity of Rabex-5/Rabaptin-5 (show RABEP1 ELISA Kits)/Rab5 (show RAB5A ELISA Kits)-GTP (show AK3 ELISA Kits) interaction in the cell, which is quantitatively related to the Rabex-5 concentration for the onset of the indirect positive feedback pathway.
Data report the identification of Rab22 as a binding site on early endosomes for direct recruitment of Rabex-5 and activation of Rab5 (show RAB5A ELISA Kits), establishing a Rab22-Rab5 (show RAB5A ELISA Kits) signaling relay to promote early endosome fusion.
these data suggest differential physiological roles of the two ubiquitin binding domains in Rabex-5.
Receptor recycling is mediated by AP-1 (show JUN ELISA Kits)/clathrin-coated vesicles and regulated by rab4 (show RAB4A ELISA Kits) and rabaptin-5 (show RABEP1 ELISA Kits)/rabex-5.
Rabex-5 is a ubiquitin ligase that binds ubiquitin and undergoes ubiquitination; the N-terminal region of Rabex-5 (residues 1-76) is important for ubiquitin binding and ubiquitination.
The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites
Rabex-5 can target to early endosomes via the EET domain and activate Rab5 (show RAB5A ELISA Kits) in a Rabaptin-5 (show RABEP1 ELISA Kits)-independent manner in vivo.
Data show that ubiquitin binding is essential for the recruitment of Rabex-5 from the cytosol to endosomes, independently of its guanine nucleotide exchange factor (show ARHGEF12 ELISA Kits) activity and of Rab5 (show RAB5A ELISA Kits).
RABGEF1 forms a complex with rabaptin-5 (RABPT5\; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A\; MIM 179512) (Horiuchi et al., 1997
, rab5 GDP/GTP exchange factor
, rabaptin-5-associated exchange factor for Rab5
, Rab5 exchange factor
, Ras negative regulator Rabex-5
, Ras negative regulator Rabex-5/Rin2
, Rab5 guanine nucleotide exchange factor Rabex-5