Browse our STXBP2 Proteins (STXBP2)

Full name:
Syntaxin Binding Protein 2 Proteins (STXBP2)
On are 5 Syntaxin Binding Protein 2 (STXBP2) Proteins from 3 different suppliers available. Additionally we are shipping STXBP2 Antibodies (42) and many more products for this protein. A total of 48 STXBP2 products are currently listed.
C79054, FHL5, Hunc18b, MUNC-18-2, Munc-18b, MUNC18-2, Munc18b, muSec1, pp10122, Sxtbp2, Sxtp2, Unc18-2, Unc18b, zgc:85807
list all proteins Gene Name GeneID UniProt
STXBP2 6813 Q15833
STXBP2 20911 Q64324
STXBP2 81804 Q62753

Show all synonyms

STXBP2 Proteins (STXBP2) by Origin

Select your origin of interest

More Proteins for STXBP2 Interaction Partners

Human Syntaxin Binding Protein 2 (STXBP2) interaction partners

  1. STXBP2 Gene Polymorphism is associated with Hemophagocytic Lymphohistocytosis.

  2. Mutation in STXBP2 gene is associated with hemophagocytic lymphohistiocytosis.

  3. Data show that Munc18b overexpression increased fusion of not only newcomer secretory granule (SG), but also predocked SGs (show FBN1 Proteins) in type-2 diabetes (T2D) human and Goto-Kakizaki Rat Islets.

  4. two novel mutations of STXBP2: c.184A>G and c.577A>C. c.184A>G (p.Asn62Asp) was located within a highly conserved region of the STXBP2 protein and predicted to be deleterious.

  5. red blood cells express Munc18-2 and that erythroid cells from patients with FHL-5 exhibit intrinsic defects caused by STXBP2/Munc18-2 mutations.

  6. Munc18-2(R65Q) and Munc18-2(R65W) retain the ability to interact with and stabilize STX11 (show STX11 Proteins). However, presence of Munc18-2(R65Q/W) in patient-derived lymphocytes and forced expression in control CTLs and NK cells diminishes degranulation and cytotoxicity.

  7. Data show that all but one patient with atypical familial hemophagocytic lymphohistiocytosis carried at least one splice-site mutation in UNC13D (show UNC13D Proteins) or STXBP2.

  8. Munc18-2 binds the N-terminal peptide of Stx11 (show STX11 Proteins) with a ~20-fold higher affinity than Stx3 (show STX3 Proteins), suggesting a potential role in selective binding.

  9. We report that FHL-5 neutrophils have a profound defect in granule mobilization, resulting in inadequate bacterial killing, in particular, of gram-negative Escherichia coli, but not of Staphylococcus aureus.

  10. Mutations in STXBP2 do not only affect cytotoxic T lymphocytes but also cause changes in the intestinal and renal epithelium resulting in severe, osmotic diarrhea and renal proximal tubular dysfunction

Mouse (Murine) Syntaxin Binding Protein 2 (STXBP2) interaction partners

  1. Munc18b as an essential gene that is a limiting component of the exocytic machinery of epithelial cells and mast cell.

  2. Munc18-1 (show STXBP1 Proteins) and Munc18-2 display distinct subcellular compartmentalization and can coordinate the insulin (show INS Proteins) exocytotic process differently as a consequence of the actual [Ca(2 (show CA2 Proteins)+)](i).

STXBP2 Protein Profile

Protein Summary

This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with STXBP2

  • syntaxin binding protein 2 (stxbp2)
  • syntaxin binding protein 2 (STXBP2)
  • syntaxin binding protein 2 (Stxbp2)
  • C79054 protein
  • FHL5 protein
  • Hunc18b protein
  • MUNC-18-2 protein
  • Munc-18b protein
  • MUNC18-2 protein
  • Munc18b protein
  • muSec1 protein
  • pp10122 protein
  • Sxtbp2 protein
  • Sxtp2 protein
  • Unc18-2 protein
  • Unc18b protein
  • zgc:85807 protein

Protein level used designations for STXBP2

syntaxin-binding protein 2 , protein unc-18 homolog B , unc-18B , munc18-2 , protein unc-18 homolog 2 , syntaxin binding protein Munc18-2 , unc-18 homolog 2 , unc18-2 , Sec1 homolog

406578 Danio rerio
515618 Bos taurus
100171766 Pongo abelii
6813 Homo sapiens
20911 Mus musculus
81804 Rattus norvegicus
403880 Canis lupus familiaris
100525152 Sus scrofa
Selected quality suppliers for STXBP2 Proteins (STXBP2)
Did you look for something else?