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this study shows an increase in ULBP3 level in alopecia areata incognita patients, which positively correlates with the age and duration of the disease
Varicella-Zoster Virus differentially modulates expression of the NKG2D (show KLRK1 ELISA Kits) ligands by upregulating MICA (show MICA ELISA Kits) expression and reducing ULBP2 (show ULBP2 ELISA Kits) and ULBP3 expression in the infected cells.
This study provides for the first time, the c-Myc (show MYC ELISA Kits) dependent regulation of NKG2D (show KLRK1 ELISA Kits) ligands, ULBP1 (show ULBP1 ELISA Kits)/2/3 in acute myeloid leukemia (show BCL11A ELISA Kits).
A greater expression of ULBP3 has also been found in hair follicles in scalp biopsy specimens from patients with active disease
A miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination.
Data show that UL142 prevents ULBP3 trafficking to the surface and protects transfected cells from NK-mediated cytotoxicity.
As NKG2D (show KLRK1 ELISA Kits) ligand, ULBP3 are expressed on immature and mature dendritic cells and plays an important role in the cytotoxic effect of NK cells against iDC (show LMNA ELISA Kits).
ULBP3 binds to the NGK2D receptor and activates multiple signaling pathways in primary natural killer cells.
ULBPs and MICA (show MICA ELISA Kits) are expressed in lipid rafts at the cell surface of NK and T cells.
Vpr specifically induces surface expression of the unique-long 16 binding proteins (ULBP)-1 (show ULBP1 ELISA Kits) and ULBP-2 (show ULBP2 ELISA Kits), but not ULBP-3
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.
, NKG2D ligand 3
, UL16-binding protein 3
, retinoic acid early transcript 1N