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study provides in vitro and in vivo evidence that the interaction between XCL1 and alpha9 integrin has an important role for autoimmune diseases
The interaction between XCL1 and XCR1 (show XCR1 Proteins) plays a crucial role in the classical immunology response.
Data show that mice lacking either XCL1 or XCR1 (show XCR1 Proteins) exhibit similar specific defects in intestinal T cell populations as XCR1 (show XCR1 Proteins)-dendritic cells (DC)-deficient mice. Therefore it is possible that the XCR1 (show XCR1 Proteins)-XCL1 axis itself is directly involved in intestinal T cell homeostasis, via a mechanism that might either involve interaction with XCR1 (show XCR1 Proteins)+ DCs or be independent of this pathway.
T inflammatory memory CD8 (show CD8A Proteins) T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production
XCL1-mediated accumulation of dendritic cells in the thymic medulla contributes to naturally occurring regulatory T cell development and is regulated by Aire (show AIRE Proteins).
Data report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells.
The expression patterns of XCR1 (show XCR1 Proteins) and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets.
MIP-1alpha (show CCL3 Proteins), MIP-1beta (show CCL4 Proteins), RANTES (show CCL5 Proteins), and ATAC/lymphotactin function together with IFN-gamma (show IFNG Proteins) as type 1 cytokines.
Adenovirus-mediated intratumoral Lptn gene transfer potentiates the antibody-targeted superantigen therapy of experimental melanoma.
In a brain-targeted HIV-1 Tat transgenic model, Tat exp (show TAT Proteins)ression up-regulates XCL1 production not only in Tat-expressing murine astrocytes, but also in monocytes and macrophages/microglia.
This study defines a Glycosaminoglycan binding surface on XCL1 dimer that includes residues that are important for HIV-1 inhibition.
Electrostatics and Hydrophobic Effects in the Metamorphic Protein Human Lymphotactin
XCL1 acts via direct interaction with the external viral envelope glycoprotein (show ERVW-1 Proteins), gp120 (show ITIH4 Proteins), to block HIV-1 infection
analysis of XCL1 and XCL2 (show XCL2 Proteins), members of the C-chemokine (show CCL1 Proteins) subfamily, in the immune system
identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3 (show CCL3 Proteins), CCL4/CCL4L1 (show CCL4 Proteins)/CCL4L2, CD160 (show CD160 Proteins), IFNG (show IFNG Proteins), NR4A3 (show NR4A3 Proteins) and XCL1/XCL2 (show XCL2 Proteins)) were analyzed in 127 kidney biopsies
XCL1 displays antimicrobial activity against E. coli and S. aureus.
XCL1-mediated inhibition is associated with direct interaction of the chemokine (show CCL1 Proteins) with the HIV-1 envelope.
In native annulus fibrosus tissue homeostasis and repair, CXCR3 (show CXCR3 Proteins) is evident, whereas XCL1 could not be detected.
Data indicated increased expression of XCL1 in CD4 (show CD4 Proteins)+ and CD8 (show CD8A Proteins)+ T cells in Wegener's granulomatosis (WG), and suggest that XCL1 might be a key modulator of T cell recruitment in WG.
The distribution characters of cattle XCR1 (show XCR1 Proteins) and XCL1 suggested a vital role in regulation of acquired immune responses and indicated a potential for a DC targeted veterinary vaccine in cattle using XCL1 fused antigens.
This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.
chemokine (C motif) ligand 1
, c motif chemokine 1
, cytokine SCM-1
, small inducible cytokine subfamily C, member 1 (lymphotactin)
, small-inducible cytokine C1
, XC chemokine ligand 1
, single cysteine motif 1a