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the heme-binding site in the N-terminal region of the mature ALAS1 protein is also necessary for the heme-dependent oxidation of ALAS1.
ALAS1 mRNA and activity were elevated approximately ~3- and 5-fold, and HMB synthase activity was approximately half-normal (~42%)
These results indicate that ALAS1 is a novel NR5A-target gene and participates in steroid hormone production.
Lon (show LONP1 Proteins) peptidase 1 (show CNDP2 Proteins) (LONP1 (show LONP1 Proteins))-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells.
REVIEW: mechanisms involving ALAS deficiency, point mutations, post translational processing, and complex formation with succinyl CoA (show OXCT1 Proteins) synthetase subunit B in the pathogenesis of hereditary sideroblastic anemia.
ALAS expression is regulated by AP-1 (show FOSB Proteins) complex through sequestration of cAMP-response element protein (CRE)-binding protein (CBP (show CREBBP Proteins)) coactivator in human cells
ALAS gene expression is regulated by Hepatic nuclear factor 3 and nuclear factor 1
First described frameshift ALAS2 (show ALAS2 Proteins) mutation, CD506-507 (-C).
in the liver of Acute liver failure patients, there may be an increase in free heme concentration which down-regulating ALAS1 gene expression
Alternative splicing of human ALAS1 generates two mRNAs with different 5'-UTRs: a major one, where exon 1B is omitted, and a minor form containing exon 1B.
RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice.
Both ALAS1 mRNA and protein content were induced in diabetic animals, accompanied by decreased Akt phosphorylation and increased nuclear FOXO1, PGC-1alpha and FOXO1-PGC-1alpha complex levels.
Egr-1 (show EGR1 Proteins) regulates the transcriptional repression of mouse delta-aminolevulinic acid synthase 1 by heme
Mice bearing a homozygous knock-in allele were lethal by embryonic day 8.5, demonstrating that ALAS-N is essential for early embryogenesis.
Ser (show SIGLEC1 Proteins)-254 is critical for formation of a competent catalytic complex by coupling succinyl-CoA (show OXCT1 Proteins) binding to enzyme conformational equilibria
identified a drug-responsive enhancer in the ALAS1 gene
Histidine-282 impacts a variety of ALAS functions, including substrate and pyridoxal 5'-phosphate (PLP (show C3 Proteins))-binding and catalysis.
The findings show that a B2 SINE retrotransposon can contribute to the regulation of ALAS1 and SINEs in 5'-UTR regions contribute to inter-individual differences in gene expression.
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme\; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified.
aminolevulinate, delta, synthase 1
, 5-aminolevulinate synthase, nonspecific, mitochondrial
, aminolevulinate, delta-, synthase 1
, 5-aminolevulinic acid synthase 1
, Delta-ALA synthetase
, delta-ALA synthase 1
, delta-aminolevulinate synthase 1
, 5-aminolevulinate synthase 1
, 5-aminolevulinate synthase, nonspecific, mitochondrial-like
, alanyl-tRNA synthetase domain-containing protein
, alanyl-tRNA synthetase protein
, 5-aminolevulinic acid synthase
, migration-inducing protein 4
, delta-ALA synthetase 1
, aminolevulinic acid synthase 1
, delta-ALA synthetase
, aminolevulinate synthase 1
, aminolevulinate synthase H
, succinyl-CoA: glycine C-succinyl transferase