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Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN413012
Barlic, Zhu, Murphy: Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion. in Journal of immunology (Baltimore, Md. : 1950) 2009
Show all 3 Pubmed References
Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN2003220
Soutar, Hawkins, Vigushin, Tennent, Booth, Hutton, Nguyen, Totty, Feest, Hsuan: Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis. in Proceedings of the National Academy of Sciences of the United States of America 1992
Show all 4 Pubmed References
Human APOA1 Protein expressed in Human - ABIN3119647
Prathipati, Zhu, Dong: Development of novel HDL-mimicking α-tocopherol-coated nanoparticles to encapsulate nerve growth factor and evaluation of biodistribution. in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2016
These data suggest that high doses of insulin (show INS Proteins) downregulate apoA-I gene expression in HepG2 cells through redistribution of FOXO1 (show FOXO1 Proteins)/LXRbeta (show NR1H2 Proteins) complex, FOXA2 (show FOXA2 Proteins), and LXRalpha (show NR1H3 Proteins) on hepatic enhancer of apoA-I gene.
Our findings suggest that serum ApoA-I level should be evaluated as a predictor of survival in patients with esophageal squamous cell carcinoma
Inflammatory markers modify the risk of recurrent coronary events associated with apolipoprotein A-I in postinfarction patients
Serum Apo (show C9orf3 Proteins)-A1 was significantly lower in term SGA newborns compared to control term newborns.
This study showed that the predictive value of apolipoprotein B (show APOB Proteins)/A-I ratio for coronary artery calcification may differ according to kidney function.
Findings suggest that the ABCG1 (show ABCG1 Proteins)-mediated efflux of cholesterol, but not of 7-ketocholesterol, shows specificity for structural domains of apoA-I bound to reconstituted HDL (show HSD11B1 Proteins). Although the mid region alone of apoA-I associated to rHDL can promote ABCG1 (show ABCG1 Proteins)-mediated cholesterol efflux, deletion of carboxyl-terminal region 185-243 from full-length apoA-I diminishes ABCG1 (show ABCG1 Proteins)-mediated cholesterol efflux.
Low APOA1 expression is associated with coronary artery disease severity.
Data suggest that activation of SR-BI (show SCARB1 Proteins) by APOAI down-regulates sphingosine 1-phosphate/S1PR2 (show S1PR2 Proteins)-mediated inflammation in vascular endothelial cells by activating the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway; oxidized-LDL does the opposite. (APOA1 = apolipoprotein A-I; SR-BI/SCARB1 (show SCARB1 Proteins) = scavenger receptor class B type I; S1PR2 (show S1PR2 Proteins) = sphingosine 1-phosphate receptor 2 (show S1PR2 Proteins); PI3K (show PIK3CA Proteins) = phosphatidylinositol 3-kinase; Akt (show AKT1 Proteins) = proto-oncogene c-akt (show AKT1 Proteins))
The minor alleles of rs662799 (APOA5 (show APOA5 Proteins)) and rs5072 (APOA1) modulate TG levels in Mexican children
Objective of this study was to understand their structural and functional role by generating domain swapped chimeras: apoE3-N-terminal/apoAI-C-terminal and apoAI-N-terminal/apoE (show APOE Proteins)-C-terminal. Results indicate that the functional attributes of apoAI and apoE3 can be conferred on each other and that N-terminal-C-terminal domain interactions significantly modulate their structure and function.
apoA-I/ABCA1 (show ABCA1 Proteins)-mediated cholesterol efflux without STAT3 (show STAT3 Proteins) activation can reduce proinflammatory cytokine expression in macrophages.
a novel protective role for ApoA-I in colitis and CAC (show SLC25A20 Proteins)
Our results assign a novel role for 4F(apoA-I mimetic peptide ) as a modulator of the TICE pathway and suggest that the anti-inflammatory functions of 4F may be a partial consequence of the codependent intestinal transport of both 4F and cholesterol.
Preincubation of endothelial cells with apoA-I protected against the TNF-alpha (show TNF Proteins)-induced inhibition of HTR (show F2R Proteins)-8/SVneo (trophoblast) cell integration into endothelial (UtMVEC) networks. These data suggest that a healthy lipid profile may affect pregnancy outcomes by priming endothelial cells in preparation for trophoblast invasion.
Reductions in Dio1 (show DIO1 Proteins) expression reduce the expression of ApoA-I in a 3,5,3'-triiodothyronine-/thyroid hormone (show PTH Proteins) response element-independent manner.
apoA-1 deficiency generates changes in the bone cell precursor population that increase adipoblast, and decrease osteoblast production resulting in reduced bone mass and impaired bone quality
This study suggests that enhancement of macrophage cholesterol metabolism by PPARgammais not contributed by activating ABCA1 (show ABCA1 Proteins) expression and ABCA1 (show ABCA1 Proteins)-mediated cholesterol efflux to apoAI, which is not involved by CD36 (show CD36 Proteins) expression either.
Mass spectrometry analysis of peptides derived from chemically crosslinked HDL (show HSD11B1 Proteins)-SAA (show SAA1 Proteins) particles detected multiple crosslinks between apoA1 and SAA (show SAA1 Proteins), indicating close proximity (within 25 A) of these two proteins on the HDL (show HSD11B1 Proteins) surface, providing a molecular and structural mechanism for the simultaneous binding of heparin to apoA1 and SAA (show SAA1 Proteins).
results demonstrate that double deletion of Apoe (show APOE Proteins) and Apoa1 ameliorated the amyloid pathology.
study suggests that apolipoprotein a1 can alleviate obesity related metabolic disease by inducing AMPK (show PRKAA1 Proteins) dependent mitochondrial biogenesis.
Alterations in the Apo A (show APOA Proteins)-I pattern is a good indicator of the presence and severity of infectious diseases in the pig.Lower overall amounts of Apo A (show APOA Proteins)-I were observed in Salmonella typhimurium and Escherichia coli infections.
down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 (show IL6 Proteins) and tumor necrosis factor-alpha (show TNF Proteins)
This study showed that apoA-I exerted protective effects against fatty liver disease in rabbits induced by a high-fat diet, possibly through its antioxidant actions.
The molar ratio ApoE (show APOE Proteins)/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
Binding of apoA-I to ectopic F(0)F(1) ATPase (show ATP5E Proteins) triggers the generation of ADP, which via activation of the purinergic receptor P2Y (show P2RY1 Proteins)(12) stimulates the uptake and transport of HDL (show HSD11B1 Proteins) and initially lipid-free apoA-I by endothelial cells.
the model of a two-step process for the transendothelial transport of apoA-I in which apoA-I is initially lipidated by ABCA1 (show ABCA1 Proteins) and then further processed by ABCA1 (show ABCA1 Proteins)-independent mechanisms.
insulin (show INS Proteins) secretion and tissue rejuvenation activities of WT-reconstituted high-density lipoproteins were nearly depleted by fructosylation, but V156K-rHDL did not lose its beneficial activity.
The NABB system using engineered zebrafish apo A-I is a native-like membrane mimetic system for G-protein-coupled receptors.
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.
, apolipoprotein A-I-like
, apolipoprotein A-I preproprotein
, apolipoprotein A1
, apolipoprotein A-1
, preproapolipoprotein A-I
, Apolipoprotein A1
, Apolipoprotein A-I