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Clock Homolog (Mouse) ELISA Kits (CLOCK)
On www.antibodies-online.com are 7 Clock Homolog (Mouse) (CLOCK) ELISA Kits from 5 different suppliers available. Additionally we are shipping CLOCK Antibodies (116) and CLOCK Proteins (5) and many more products for this protein. A total of 136 CLOCK products are currently listed.
Synonyms:
5330400M04Rik, bHLHe8, bHLHe10, CG7391, clk, clock, dClck, dclk, dCLK/JRK, dClock, Dmel\\CG7391, Jerk, jrk, KAT13D, mKIAA0334, PAS1, Xclk, XClock, zCLOCK1, zfCLOCK1
list all ELISA KIts Gene Name GeneID UniProt
CLOCK 12753 O08785
CLOCK 60447 Q9WVS9
CLOCK 9575 O15516

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More ELISA Kits for CLOCK Interaction Partners

Fruit Fly (Drosophila melanogaster) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC (show COX6C ELISA Kits) E-box binding, thus enhancing the removal of CLK-CYC (show COX6C ELISA Kits) from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC (show COX6C ELISA Kits) from E-boxes

  2. these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.

  3. Our findings suggest a novel role for clock protein (show ARNTL ELISA Kits) phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.

  4. These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.

  5. Computational dissection of CLK/CYC (show COX6C ELISA Kits) context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites

  6. usp8 (show USP8 ELISA Kits) loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8 (show USP8 ELISA Kits)-DN) enhances CLK/CYC (show COX6C ELISA Kits) transcriptional activity and alters fly locomotor activity rhythms

  7. CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation

  8. CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning

  9. dPER(DeltaCBD) does not provoke the daily hyperphosphorylation of dCLOCK, indicating that direct interactions between dPER and dCLOCK are necessary for the dCLOCK phosphorylation

  10. findings show that Clk and cyc (show COX6C ELISA Kits) act during starvation to modulate the conflict of whether flies sleep or search for food

Zebrafish Clock Homolog (Mouse) (CLOCK) interaction partners

  1. effect of CRY (show CRY2 ELISA Kits) in repressing transcription mediated by CLOCK-BMAL heterodimer

Mouse (Murine) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. results demonstrate that the core circadian gene Clock regulates bone formation via transcriptional control of 1,2,5(OH)2D3 receptor PDIA3 (show PDIA3 ELISA Kits)

  2. These results suggest that bone resorption and bone mass are regulated at a sophisticated level by osteoblastic Clock system through a mechanism relevant to the modulation of 1,25(OH)2 D3 -induced Rankl (show TNFSF11 ELISA Kits) expression in osteoblasts.

  3. Abundance of CDH1 (show CDH1 ELISA Kits) and TP63 (show TP63 ELISA Kits) proteins were significantly reduced in cultures transfected with shClock These data support how CLOCK plays a role in regulation of epithelial cell growth and differentiation in the mammary gland.

  4. Data demonstrate that CLOCK and BMAL1 (show ARNTL ELISA Kits) regulate muscle insulin (show INS ELISA Kits) sensitivity via SIRT1 (show SIRT1 ELISA Kits), and activation of SIRT1 (show SIRT1 ELISA Kits) might be a potential valuable strategy to attenuate muscle insulin (show INS ELISA Kits) resistance related to circadian misalignment.

  5. These data establish the importance of circadian CLOCK-inhibin signaling in sepsis.

  6. our results indicate that Clock is a key regulator of AKT (show AKT1 ELISA Kits) signalling for triggering cardiac hypertrophy in vivo.

  7. Report altered BMAL1 (show ARNTL ELISA Kits)/CLOCK expression in conditions of chronically altered blood flow.

  8. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (show GC ELISA Kits) gene by targeting BMAL1 (show ARNTL ELISA Kits) and CLOCK.

  9. Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1 (show ARNTL ELISA Kits):CLOCK to conserved DNA elements

  10. RNA interference screens reveal the heterodimeric, circadian rhythm Transcription factors Clock and Bmal1 (show ARNTL ELISA Kits) as genes required for the growth of acute myeloid leukemia (show BCL11A ELISA Kits) cells in vitro and in vivo.

Human Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Clock circadian regulator (CLOCK) gene single nucleotide polymorphism rs1801260 minor allele C showed a significantly higher association with the prevalence of diabetes in the Japanese population independent of body mass index (BMI).

  2. Immunostaining of CLOCK and PER2 (show PER2 ELISA Kits) protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 (show PER2 ELISA Kits) can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation

  3. possible circadian rhythm in full-term placental expression

  4. Findings indicate that CLOCK protein (show ARNTL ELISA Kits) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  5. Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins.

  6. when overexpressed, c-MYC (show MYC ELISA Kits) is able to repress Per1 (show PER1 ELISA Kits) transactivation by BMAL1 (show ARNTL ELISA Kits)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (show MYC ELISA Kits) was detected in BMAL1 (show ARNTL ELISA Kits) protein complexes

  7. CLOCK, ARNTL (show ARNTL ELISA Kits), and NPAS2 (show NPAS2 ELISA Kits) gene polymorphisms may have a role in seasonal variations in mood and behavior

  8. minor polymorphisms of CLOCK may be associated with poor morning gastric motility, and may have a combinatorial effect with PER3.

  9. these findings suggest that sumoylation plays a critical role in the spatiotemporal co-activation of CLOCK-BMAL1 (show ARNTL ELISA Kits) by CBP (show CREBBP ELISA Kits) for immediate-early (show JUN ELISA Kits) Per induction and the resetting of the circadian clock.

  10. the circadian gene hClock promoted CRC (show CALR ELISA Kits) progression and inhibit tumor cell apoptosis in vitro and in vivo, while silencing hClock was able to reverse this effect.

Xenopus laevis Clock Homolog (Mouse) (CLOCK) interaction partners

  1. the second half of the photolyase homology region (PHR) of CRY (show CRY2 ELISA Kits) is important for repression through facilitating interaction with CLOCK

CLOCK Antigen Profile

Antigen Summary

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CLOCK

  • Clock (Clk) Elisa Kit
  • clock homolog (mouse) (CLOCK) Elisa Kit
  • clock circadian regulator (clock) Elisa Kit
  • clock homolog (CLOCK) Elisa Kit
  • clock (clock) Elisa Kit
  • circadian locomotor output cycles kaput (Clock) Elisa Kit
  • clock circadian regulator (Clock) Elisa Kit
  • clock circadian regulator (CLOCK) Elisa Kit
  • 5330400M04Rik Elisa Kit
  • bHLHe8 Elisa Kit
  • bHLHe10 Elisa Kit
  • CG7391 Elisa Kit
  • clk Elisa Kit
  • clock Elisa Kit
  • dClck Elisa Kit
  • dclk Elisa Kit
  • dCLK/JRK Elisa Kit
  • dClock Elisa Kit
  • Dmel\\CG7391 Elisa Kit
  • Jerk Elisa Kit
  • jrk Elisa Kit
  • KAT13D Elisa Kit
  • mKIAA0334 Elisa Kit
  • PAS1 Elisa Kit
  • Xclk Elisa Kit
  • XClock Elisa Kit
  • zCLOCK1 Elisa Kit
  • zfCLOCK1 Elisa Kit

Protein level used designations for CLOCK

CG7391-PA , CG7391-PD , CG7391-PF , CG7391-PG , CG7391-PH , CLOCK , Clk-PA , Clk-PD , Clk-PF , Clk-PG , Clk-PH , clock , dClock , clock homolog (mouse) , clock homolog , circadian locomoter output cycles protein kaput , circadian locomoter output cycles protein kaput-like , Clock1a , clk1 , circadian locomoter output cycles kaput , mCLOCK , rCLOCK , circadian locomoter output cycles kaput protein , class E basic helix-loop-helix protein 8 , circadian rhythmicity protein CLOCK

GENE ID SPECIES
38872 Drosophila melanogaster
461312 Pan troglodytes
475145 Canis lupus familiaris
786637 Bos taurus
100008576 Meleagris gallopavo
100017022 Monodelphis domestica
100034166 Equus caballus
100038163 Xenopus (Silurana) tropicalis
100171391 Ovis aries
100172630 Pongo abelii
100349684 Oryctolagus cuniculus
100407407 Callithrix jacchus
30140 Danio rerio
100606130 Nomascus leucogenys
100628097 Sus scrofa
12753 Mus musculus
60447 Rattus norvegicus
9575 Homo sapiens
399157 Xenopus laevis
373991 Gallus gallus
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