Browse our CLOCK Proteins (CLOCK)

Full name:
Clock Homolog (Mouse) Proteins (CLOCK)
On are 5 Clock Homolog (Mouse) (CLOCK) Proteins from 3 different suppliers available. Additionally we are shipping CLOCK Antibodies (118) and CLOCK Kits (7) and many more products for this protein. A total of 138 CLOCK products are currently listed.
5330400M04Rik, bHLHe8, bHLHe10, CG7391, clk, clock, dClck, dclk, dCLK/JRK, dClock, Dmel\\CG7391, Jerk, jrk, KAT13D, mKIAA0334, PAS1, Xclk, XClock, zCLOCK1, zfCLOCK1
list all proteins Gene Name GeneID UniProt
CLOCK 12753 O08785
CLOCK 9575 O15516

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CLOCK Proteins (CLOCK) by Origin

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More Proteins for CLOCK Interaction Partners

Fruit Fly (Drosophila melanogaster) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC (show COX6C Proteins) E-box binding, thus enhancing the removal of CLK-CYC (show COX6C Proteins) from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC (show COX6C Proteins) from E-boxes

  2. these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.

  3. Our findings suggest a novel role for clock protein (show ARNTL Proteins) phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.

  4. These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.

  5. Computational dissection of CLK/CYC (show COX6C Proteins) context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites

  6. usp8 (show USP8 Proteins) loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8 (show USP8 Proteins)-DN) enhances CLK/CYC (show COX6C Proteins) transcriptional activity and alters fly locomotor activity rhythms

  7. CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation

  8. CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning

  9. dPER(DeltaCBD) does not provoke the daily hyperphosphorylation of dCLOCK, indicating that direct interactions between dPER and dCLOCK are necessary for the dCLOCK phosphorylation

  10. findings show that Clk and cyc (show COX6C Proteins) act during starvation to modulate the conflict of whether flies sleep or search for food

Zebrafish Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Data suggest that Clock1a coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 (show SMAD3 Proteins) signaling; Clock1a alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a activates Smad3a (show SMAD3 Proteins) promoter via its E-box1 element. (Clock1a = clock circadian regulator a; Nodal = nodal modulator 1 (show NOMO1 Proteins); Smad3a (show SMAD3 Proteins) = SMAD (show SMAD1 Proteins) family member 3a)

  2. effect of CRY (show CRY2 Proteins) in repressing transcription mediated by CLOCK-BMAL heterodimer

Mouse (Murine) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Development of Mineralocorticoid receptor (show NR3C2 Proteins)-mediated cardiac inflammation and fibrosis is dependent on intact signaling by the circadian protein CLOCK.

  2. Clock protein (show ARNTL Proteins) role in proteasomal and autophagic BMAL1 (show ARNTL Proteins) degradation and glucose homeostasis

  3. CLOCK transcription control of Wnt (show WNT2 Proteins) signaling promotes cell cycle progression in 3T3-L1 preadipocytes.

  4. results demonstrate that the core circadian gene Clock regulates bone formation via transcriptional control of 1,2,5(OH)2D3 receptor PDIA3 (show PDIA3 Proteins)

  5. These results suggest that bone resorption and bone mass are regulated at a sophisticated level by osteoblastic Clock system through a mechanism relevant to the modulation of 1,25(OH)2 D3 -induced Rankl (show TNFSF11 Proteins) expression in osteoblasts.

  6. Abundance of CDH1 (show CDH1 Proteins) and TP63 (show TP63 Proteins) proteins were significantly reduced in cultures transfected with shClock These data support how CLOCK plays a role in regulation of epithelial cell growth and differentiation in the mammary gland.

  7. Data demonstrate that CLOCK and BMAL1 (show ARNTL Proteins) regulate muscle insulin (show INS Proteins) sensitivity via SIRT1 (show SIRT1 Proteins), and activation of SIRT1 (show SIRT1 Proteins) might be a potential valuable strategy to attenuate muscle insulin (show INS Proteins) resistance related to circadian misalignment.

  8. These data establish the importance of circadian CLOCK-inhibin signaling in sepsis.

  9. our results indicate that Clock is a key regulator of AKT (show AKT1 Proteins) signalling for triggering cardiac hypertrophy in vivo.

  10. Report altered BMAL1 (show ARNTL Proteins)/CLOCK expression in conditions of chronically altered blood flow.

Human Clock Homolog (Mouse) (CLOCK) interaction partners

  1. This study showed that Lack of Association between Genetic Polymorphism of clock gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population This study showed that Lack of Association between Genetic Polymorphism of PER2 (show PER2 Proteins) gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population

  2. found that overexpression of both Clock and Bmal1 (show ARNTL Proteins) suppressed cell growth

  3. Clock circadian regulator (CLOCK) gene single nucleotide polymorphism rs1801260 minor allele C showed a significantly higher association with the prevalence of diabetes in the Japanese population independent of body mass index (BMI).

  4. Immunostaining of CLOCK and PER2 (show PER2 Proteins) protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 (show PER2 Proteins) can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation

  5. possible circadian rhythm in full-term placental expression

  6. Findings indicate that CLOCK protein (show ARNTL Proteins) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  7. Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins.

  8. when overexpressed, c-MYC (show MYC Proteins) is able to repress Per1 (show PER1 Proteins) transactivation by BMAL1 (show ARNTL Proteins)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (show MYC Proteins) was detected in BMAL1 (show ARNTL Proteins) protein complexes

  9. CLOCK, ARNTL (show ARNTL Proteins), and NPAS2 (show NPAS2 Proteins) gene polymorphisms may have a role in seasonal variations in mood and behavior

  10. minor polymorphisms of CLOCK may be associated with poor morning gastric motility, and may have a combinatorial effect with PER3.

Xenopus laevis Clock Homolog (Mouse) (CLOCK) interaction partners

  1. the second half of the photolyase homology region (PHR) of CRY (show CRY2 Proteins) is important for repression through facilitating interaction with CLOCK

CLOCK Protein Profile

Protein Summary

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CLOCK

  • Clock (Clk)
  • clock homolog (mouse) (CLOCK)
  • clock circadian regulator (clock)
  • clock homolog (CLOCK)
  • clock (clock)
  • circadian locomotor output cycles kaput (Clock)
  • clock circadian regulator (Clock)
  • clock circadian regulator (CLOCK)
  • 5330400M04Rik protein
  • bHLHe8 protein
  • bHLHe10 protein
  • CG7391 protein
  • clk protein
  • clock protein
  • dClck protein
  • dclk protein
  • dCLK/JRK protein
  • dClock protein
  • Dmel\\CG7391 protein
  • Jerk protein
  • jrk protein
  • KAT13D protein
  • mKIAA0334 protein
  • PAS1 protein
  • Xclk protein
  • XClock protein
  • zCLOCK1 protein
  • zfCLOCK1 protein

Protein level used designations for Clock Homolog (Mouse) Proteins (CLOCK)

CG7391-PA , CG7391-PD , CG7391-PF , CG7391-PG , CG7391-PH , CLOCK , Clk-PA , Clk-PD , Clk-PF , Clk-PG , Clk-PH , clock , dClock , clock homolog (mouse) , clock homolog , circadian locomoter output cycles protein kaput , circadian locomoter output cycles protein kaput-like , Clock1a , clk1 , circadian locomoter output cycles kaput , mCLOCK , rCLOCK , circadian locomoter output cycles kaput protein , class E basic helix-loop-helix protein 8 , circadian rhythmicity protein CLOCK

38872 Drosophila melanogaster
461312 Pan troglodytes
475145 Canis lupus familiaris
786637 Bos taurus
100008576 Meleagris gallopavo
100017022 Monodelphis domestica
100034166 Equus caballus
100038163 Xenopus (Silurana) tropicalis
100171391 Ovis aries
100172630 Pongo abelii
100349684 Oryctolagus cuniculus
100407407 Callithrix jacchus
30140 Danio rerio
100606130 Nomascus leucogenys
100628097 Sus scrofa
12753 Mus musculus
60447 Rattus norvegicus
9575 Homo sapiens
399157 Xenopus laevis
373991 Gallus gallus
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