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the single nucleotide polymorphism rs174547 (T/C) of the fatty acid desaturase-1 gene, FADS1, is associated with changes in arachidonic acid compositions of the blood of elderly Japanese
Our results demonstrate that FADS1-FADS2 (show FADS2 ELISA Kits) are susceptibility genes for PCOS.
FADS1 rs174546 single nucleotide polymorphism correlation with fatty acids profiles in blood
Single nucleotide polymorphisms in FADS gene (particularly rs174537) associate with plasma fatty acids and desaturase levels in patients with both type 2 diabetes and coronary artery disease.
FADS1 variants modulate the relationship between marine fatty acid intake and circulating levels of long-chain omega-3 fatty acids.
polymorphisms in the FADS gene cluster were nominally associated with reduced risk of developing atopic eczema
genetic association study in population of pregnant women in Republic of Seychelles: SNPs in FADS1/FADS2 (show FADS2 ELISA Kits) are associated with maternal arachidonic acid status; a subtle association exists with neurodevelopment in this high fish-eating population. [REVIEW]
Suggest that the FADS1 rs174546 SNP and the FADS2 (show FADS2 ELISA Kits) rs174601 SNP are associated with the risk of coronary artery disease and ischemic stroke, and are likely to influence serum lipid levels.
genome-wide association study in population of mother/infant dyads in Denmark: Data suggest SNPs in maternal FADS1 are associated with (1) lower breast milk polyunsaturated fatty acid and (2) higher production of interleukins by infant T-lymphocytes.
Dietary fatty acids modulate associations between FADS1 genetic variants and circulating fatty acids in plasma and erythrocyte membranes.
knockdown of Elovl5 (show ELOVL5 ELISA Kits), Fads1, or Fads2 (show FADS2 ELISA Kits) decreased the level of Mead acid.
The Systemic disruption of the Fads1 gene reciprocally altered the levels of dihomo-gamma-linolenic acid and AA in mouse tissues, resulting in a profound increase in 1-series-derived and a concurrent decrease in 2-series-derived prostaglandins.
analysis of mRNA abundance and expression of SLC27A, ACC (show ACACA ELISA Kits), SCD (show SCD ELISA Kits), FADS, LPIN, INSIG, and PPARGC1 (show PPARGC1A ELISA Kits) gene isoforms in mouse mammary glands during the lactation cycle
n-3 fatty acid desaturase (show SCD ELISA Kits) may have a role in colitis-associated colon cancer in mice
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1\; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.
, delta(5) fatty acid desaturase
, delta-5 desaturase
, delta-5 fatty acid desaturase
, linoleoyl-CoA desaturase (delta-6-desaturase)-like 1
, fatty acid desaturase 1