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Purification and characterization of the plastid-localized NAD-dependent malate dehydrogenase from Arabidopsis thaliana
The critical role of plastidial NAD-specific MDH isoform in Arabidopsis (Arabidopsis thaliana) plants, is reported.
Arabidopsis thaliana mutants lacking the NADP-malate dehydrogenase have lost the reversible inactivation of catalase (show CAT Proteins) activity and the increase in H2O2 levels when exposed to high light.
plastid-localized NAD-dependent malate dehydrogenase is crucial for energy homeostasis in developing Arabidopsis thaliana seeds
mMDH (show MDH2 Proteins) has a role in maximizing photorespiratory rate.
deletion of malic enzyme 2 (show NAD-ME Proteins) confers collateral lethality in pancreatic cancer
ME1 (show ME1 Proteins)/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions.
Data indicate that malic enzyme 2 (show NAD-ME Proteins) knockdown impacts phosphatidylinositol 3-kinases/proto-oncogene (show RAB1A Proteins) protein akt (show AKT1 Proteins) (PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)) signaling.
ME2 might be an important factor in melanoma progression and a novel biomarker of invasion.
Three SNP alleles in BRD2 (show BRD2 Proteins), Cx-36 (show GJD2 Proteins), and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy.
p53 (show TP53 Proteins) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 (show ME1 Proteins) and ME2 in human and mouse cells
Depletion of malic enzyme 2 (show NAD-ME Proteins) induced erythroid differentiation in human erythroleukemia cells.
An ME2-centered nine-SNP haplotype, when present homozygously, increases the risk for IGE (odds ratio 6.1; 95% confidence interval 2.9-12.7) compared with any other genotype
Schizophrenic subjects are identified with mitochondrial genes involved in oxidative metabolism as showing consistently decreased expression, including ME2.
Single nucleotide polymorphism in ME2 gene is associated with acute lymphoblastic leukemia.
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.
, malic DH
, malic enzyme b
, oxidoreductase, putative
, malate dehydrogenase
, NAD-dependent malic enzyme, mitochondrial
, pyruvic-malic carboxylase