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mammalian mediator subunit mMED8 is an elongin BC-interacting protein that can assemble with Cul2 and Rbx1 reconstitute a ubiquitin ligase (Ubc5; E2 ubiquitin-conjugating enzyme Ubc5)
ability to inhibit both host transcription and the interferon (show IFNA ELISA Kits) response is linked to interaction of NSs with the MED8 component of Mediator, a protein complex necessary for mRNA production
This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
mediator of RNA polymerase II transcription subunit 8
, mediator of RNA polymerase II transcription, subunit 8 homolog
, hypothetical protein
, mediator complex subunit 8-A
, mediator of RNA polymerase II transcription subunit 8-A
, activator-recruited cofactor 32 kDa component
, mediator of RNA polymerase II transcription subunit MED8
, mediator complex subunit 8