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our investigation shows that the ER membrane protein TCF11/Nrf1 (show NFE2L1 Proteins) is an essential component of the cellular stress response mechanism. In response to cytotoxic stress, TCF11/Nrf1 (show NFE2L1 Proteins) is retrotranslocated and transferred to the nucleus where it induces proteasome subunit expression via binding to the ARE region of the relevant promoter.
Deficiency of long isoforms of Nfe2l1 in pancreatic beta-cells increased susceptibility to acute arsenite-induced cytotoxicity by promoting arsenic biotransformation and intracellular MMA levels.
Nrf1 knockdown suppressed the death of ubiquitin-deficient N2a cells upon exposure to As(III). Therefore, the levels of p65 (show NFkBP65 Proteins)-Nrf1 may play an important role in the maintenance of cell viability under oxidative stress induced (show SQSTM1 Proteins) by As(III).
findings suggest that neurodegeneration in Nrf1 NKO mice may stem from the dysfunction of the ubiquitin-mediated regulation of neuronal proteins
Our findings demonstrate that DEE and a fraction derived from this extract exerts anti-inflammatory effects through Nrf2dependent HO-1 (show HMOX1 Proteins) expression
NRF1 (nuclear respiratory factor 1) is a methylation-sensitive transcription factor; in the absence of DNA methylation (show HELLS Proteins), NRF1 binds to new sites and induces aberrant transcription
Nrf1 plays critical roles in regulating glucose metabolism, mitochondrial function, and insulin (show INS Proteins) secretion, suggesting that Nrf1 may be a novel target to improve the function of insulin (show INS Proteins)-secreting beta-cells.
Nrf1 is negatively regulated by its O-GlcNAcylation status that depends on the glucose concentrations
lysine-specific demethylase (show MBD2 Proteins) 1 promotes oxidative phosphorylation in white adipose tissue, in cooperation with Nrf1.
Results show that Nrf1 may not be directly responsible for (show GCLC Proteins) the loss (show GCLM Proteins) of Nrf2-dependent inducibility of a (show HBe1 Proteins)ntioxidant and cytoprotective genes observed in aged animals.
Here the authors show that the aspartyl protease DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and activate Nrf1 (show NFE2L1 Proteins).
this study therefore identifies NRF-1 (show NFE2L1 Proteins) as a novel regulator of HIF-1a (show HIF1A Proteins).
These results uncover a new regulatory mechanism that USP15 (show USP15 Proteins) activates Nrf1 (show NFE2L1 Proteins) against the beta-TrCP (show BTRC Proteins) inhibition to maintain proteostasis.
NRF-1 (show NFE2L1 Proteins) and its target mitochondrial transcription factor A (TFAM (show TFAM Proteins)) were higher in Tamoxifen (TAM (show CCNA1 Proteins))-resistant LCC2 and LCC9 cells than TAM (show CCNA1 Proteins)-sensitive MCF-7 cells.
NRF1 (show NFE2L1 Proteins) overexpression attenuated BPDEinduced Sphase arrest via the ATM (show ATM Proteins)/Chk2 (show CHEK2 Proteins) signaling pathway.
Importantly, Nrf1 activity is positively and/or negatively regulated by distinct doses of proteasome and calpain inhibitors
Low NRF1 (show NFE2L1 Proteins) expression was associated lymphatic metastasis and radio-resistance in nasopharyngeal carcinoma.
EglN2 (show EGLN2 Proteins) associates with the NRF1 (show NFE2L1 Proteins)-PGC1alpha complex and controls mitochondrial function in breast cancer
Lack of aprataxin (show APTX Proteins) impairs mitochondrial functions via downregulation of the APE1 (show APEX1 Proteins)/NRF1 (show NFE2L1 Proteins)/NRF2 (show GABPA Proteins) pathway.
Transcription Factor A (show GTF3A Proteins) expression associated with mitochondrial biogenesis activation & high levels of NRF1 mRNA from oocyte stage onwards argue for essential function of these factors during 1st steps of bovine embryogenesis
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
nuclear respiratory factor 1
, nuclear respiratory factor-1
, NF-E2-related factor 1
, NFE2-related factor 1
, nuclear factor erythroid 2-related factor 1
, alpha palindromic-binding protein
, not really finished protein
, transcription factor