Browse our DDIT3 Proteins (DDIT3)

Full name:
DNA-Damage-Inducible Transcript 3 Proteins (DDIT3)
On are 19 DNA-Damage-Inducible Transcript 3 (DDIT3) Proteins from 9 different suppliers available. Additionally we are shipping DDIT3 Antibodies (204) and DDIT3 Kits (34) and many more products for this protein. A total of 271 DDIT3 products are currently listed.
CEBPZ, CHOP, CHOP-10, Chop10, GADD153, Xchop
list all proteins Gene Name GeneID UniProt
DDIT3 13198 P35639
DDIT3 29467  
DDIT3 1649 P35638

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DDIT3 Proteins (DDIT3) by Origin

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Top referenced DDIT3 Proteins

  1. Human DDIT3 Protein expressed in Escherichia coli (E. coli) - ABIN667718 : Oyadomari, Mori: Roles of CHOP/GADD153 in endoplasmic reticulum stress. in Cell death and differentiation 2004 (PubMed)
    Show all 2 references for 667718

More Proteins for DDIT3 Interaction Partners

Mouse (Murine) DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. Free CNPY2 (show CNPY2 Proteins) then engages protein kinase (show CDK7 Proteins) R-like endoplasmic reticulum kinase (PERK (show EIF2AK3 Proteins)) to induce expression of the transcription factor C/EBP homologous protein (CHOP), thereby initiating the unfolded protein response.

  2. SHP (show LAMC1 Proteins) and REV-ERBalpha (show NR1D1 Proteins) play a critical role in controlling rhythmic CHOP expression in alcoholic fatty liver

  3. ER stress-induced increase in ATF4 (show ATF4 Proteins) and CHOP expression is initiated by an increase in Atf4 (show ATF4 Proteins) and Chop mRNA, which is also dependent upon eIF2alpha (show EIF2A Proteins) phosphorylation.

  4. Upregulating HSF1 (show HSF1 Proteins) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP and increasing HSP70 (show HSP70 Proteins) a5 (BiP/GRP78 (show HSPA5 Proteins)). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (show HSF1 Proteins) being one likely key player in both systems.

  5. Study showed that Chop is involved in the pathogenesis of pulmonary fibrosis by regulating the generation of M2 macrophages and TGF-beta (show TGFB1 Proteins) signaling.

  6. AMPKalpha1 (show PRKAA1 Proteins) mediates CHOP ubiquitination and proteasomal degradation in macrophages by promoting the phosphorylation of CHOP at serine 30. Transfection of Chop-specific siRNA but not control siRNA reduced both CHOP level and injury-induced neointimal disruption in vivo.

  7. The data presented indicate that the unfolded protein response is activated in fibrotic lung tissue and strongly localized to macrophages. GRP78 (show HSPA5 Proteins)- and CHOP-mediated macrophage apoptosis was found to protect against bleomycin-induced fibrosis.

  8. Deletion of CHOP attenuates dysfunction of the autophagy/lysosomal pathway in beta-cells of transgenic mice.

  9. Interference with DOT1L (show DOT1L Proteins) activity resulted in transcriptional activation of Atf4 (show ATF4 Proteins) and Ddit3 accompanied by decreased levels of H3K79 dimethylation.

  10. this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK (show EIF2AK3 Proteins) and a downstream effector of its activation, CHOP, in tubule cell production of fibronectin (show FN1 Proteins)

Human DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. The role of neutrophil elastase (show ELANE Proteins) in the activation of unfolded protein response effector molecules via PERK (show EIF2AK3 Proteins) and CHOP is reported.

  2. The PERK (show EIF2AK3 Proteins)-eIF2alpha (show EIF2A Proteins)-ATF4 (show ATF4 Proteins)-CHOP signaling pathway has a critical role in tumor progression during endoplasmic reticulum stress. (Review)

  3. HDL (show HSD11B1 Proteins) isolated from patients with metabolic syndrome induced macrophage apoptosis, oxidative stress, and CHOP upregulation, which were blocked by PBA and DPI. These data indicate that ox-HDL (show HSD11B1 Proteins) may activate ER stress-CHOP-induced apoptotic pathway in macrophages via enhanced oxidative stress and that this pathway may be mediated by TLR4 (show TLR4 Proteins).

  4. We found that 25-epi (show TFPI Proteins) Ritterostatin GN1N induced cell death in melanoma cells at nanomolar concentrations, and this cell death was characterized by inhibition of GRP78 (show HSPA5 Proteins) expression, increased expression of the ER stress marker CHOP, loss of mitochondrial membrane potential, and lipidation of the autophagy marker protein LC3B (show MAP1LC3B Proteins).

  5. Western blot analysis of subcutaneously implanted AsPC-1 and BxPC-3 tumors as well as orthotopically implanted Panc-1 tumors demonstrated upregulation of BIP (show GDF10 Proteins), CHOP, and IRE1alpha (show ERN1 Proteins) expression in the tumor lysates from penfluridol-treated mice as compared to tumors from control mice

  6. CHOP protects hepatocytes from a diet high in fat, fructose, and cholesterol (HFCD) and its induced ER stress, and has a significant role in the mechanism of liraglutide-mediated protection against non-alcoholic steatohepatitis (NASH (show SAMSN1 Proteins)) pathogenesis.

  7. Study showed that Chop is involved in the pathogenesis of pulmonary fibrosis by regulating the generation of M2 macrophages and TGF-beta (show TGFB1 Proteins) signaling.

  8. Downregulation of CHOP by small interfering RNA somewhat restored expression of AR suggesting that AR degradation is dependent on ER stress pathway. Future studies will need to evaluate other aspects of the unfolded protein response pathway to characterize the regulation of AR degradation

  9. Herein, the authors extend their previous research and provide evidence that ORF57 of human herpesvirus-8 interacts with CHTOP (show CHTOP Proteins) and CIP29 (show SARNP Proteins), in contrast to POLDIP3 (show POLDIP3 Proteins).

  10. NAG-1 (show GDF15 Proteins) expression was transcriptionally upregulated by CHOP, which promoted chemokine (show CCL1 Proteins) production through sustained NF-kappaB (show NFKB1 Proteins) activation.

Xenopus laevis DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. CHOP (GADD153) is an inhibitor of Wnt (show WNT2 Proteins)/TCF (show HNF4A Proteins) signals

DDIT3 Protein Profile

Protein Summary

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Alternative names and synonyms associated with DDIT3

  • DNA-damage-inducible transcript 3 (ddit3)
  • DNA-damage inducible transcript 3 (Ddit3)
  • DNA-damage-inducible transcript 3 (DDIT3)
  • DNA-damage-inducible transcript 3 (Ddit3)
  • DNA-damage-inducible transcript 3 (LOC100338439)
  • CEBPZ protein
  • CHOP protein
  • CHOP-10 protein
  • Chop10 protein
  • GADD153 protein
  • Xchop protein

Protein level used designations for DDIT3

C/EBP homoologous protein 10 , C/EBP zeta , CCAAT/enhancer-binding protein homologous protein , DDIT-3 , DNA damage-inducible transcript 3 protein , c/EBP-homologous protein 10 , growth arrest and DNA-damage-inducible protein GADD153 , C/EBP homologous protein , growth arrest and DNA damage-inducible protein GADD153 , growth arrest and DNA damage-inducible , transcription factor GADD153 , C/EBP-homologous protein 10 , DNA-damage inducible transcript 3

733816 Xenopus (Silurana) tropicalis
13198 Mus musculus
29467 Rattus norvegicus
1649 Homo sapiens
398615 Xenopus laevis
777788 Bos taurus
607439 Canis lupus familiaris
100857832 Gallus gallus
101787388 Cavia porcellus
100240743 Sus scrofa
100338439 Oryctolagus cuniculus
541600 Ovis aries
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