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GPR4 (show GPR4 Proteins) blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression.
CHOP deficiency prevents HFD-induced insulin (show INS Proteins) resistance.
Endoplasmic reticulum stress-induced CHOP activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin (show LEP Proteins) and IGF1 (show IGF1 Proteins).
a significant protein-protein interaction between GR and CHOP, (GR-CHOP heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
The study shows that FXR (show NR1H4 Proteins)/RXR regulates Chop expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.
Ddit3 suppresses the differentiation of ATDC5 cells
Free CNPY2 (show CNPY2 Proteins) then engages protein kinase (show CDK7 Proteins) R-like endoplasmic reticulum kinase (PERK (show EIF2AK3 Proteins)) to induce expression of the transcription factor C/EBP homologous protein (CHOP), thereby initiating the unfolded protein response.
SHP (show LAMC1 Proteins) and REV-ERBalpha (show NR1D1 Proteins) play a critical role in controlling rhythmic CHOP expression in alcoholic fatty liver
ER stress-induced increase in ATF4 (show ATF4 Proteins) and CHOP expression is initiated by an increase in Atf4 (show ATF4 Proteins) and Chop mRNA, which is also dependent upon eIF2alpha (show EIF2A Proteins) phosphorylation.
Upregulating HSF1 (show HSF1 Proteins) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP and increasing HSP70 (show HSP70 Proteins) a5 (BiP/GRP78 (show HSPA5 Proteins)). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (show HSF1 Proteins) being one likely key player in both systems.
CHOP negatively regulates Polo-like kinase 2 (show PLK2 Proteins) expression via recruiting C/EBPalpha (show CEBPA Proteins) to the upstream-promoter in human osteosarcoma cell line during ER stress
VEGF is an important angiogenic signal required for tissue expansion. We show that VEGFA variation giving allele-specific response to transcription factors with overlapping binding sites associate closely with circulating TSH levels. Because CHOP is induced by several types of intracellular stress, this indicates that cellular stress could be involved in the normal or pathophysiological response of the thyroid to TSH
GRP78 (show HSPA5 Proteins) inhibition enhances ATF4 (show ATF4 Proteins)-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma cells.
These results suggest that Bacteroides fragilis enterotoxin induced accumulation of autophagosomes in endothelial cells, but activation of a signaling pathway involving JNK (show MAPK8 Proteins), AP-1 (show FOSB Proteins), and CHOP may interfere with complete autophagy.
The role of neutrophil elastase (show ELANE Proteins) in the activation of unfolded protein response effector molecules via PERK (show EIF2AK3 Proteins) and CHOP is reported.
The PERK (show EIF2AK3 Proteins)-eIF2alpha (show EIF2A Proteins)-ATF4 (show ATF4 Proteins)-CHOP signaling pathway has a critical role in tumor progression during endoplasmic reticulum stress. (Review)
HDL (show HSD11B1 Proteins) isolated from patients with metabolic syndrome induced macrophage apoptosis, oxidative stress, and CHOP upregulation, which were blocked by PBA and DPI. These data indicate that ox-HDL (show HSD11B1 Proteins) may activate ER stress-CHOP-induced apoptotic pathway in macrophages via enhanced oxidative stress and that this pathway may be mediated by TLR4 (show TLR4 Proteins).
CHOP (GADD153) is an inhibitor of Wnt (show WNT2 Proteins)/TCF (show HNF4A Proteins) signals
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
C/EBP homoologous protein 10
, C/EBP zeta
, CCAAT/enhancer-binding protein homologous protein
, DNA damage-inducible transcript 3 protein
, c/EBP-homologous protein 10
, growth arrest and DNA-damage-inducible protein GADD153
, C/EBP homologous protein
, growth arrest and DNA damage-inducible protein GADD153
, growth arrest and DNA damage-inducible
, transcription factor GADD153
, C/EBP-homologous protein 10
, DNA-damage inducible transcript 3