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Browse our DDIT3 Proteins (DDIT3)

Full name:
DNA-Damage-Inducible Transcript 3 Proteins (DDIT3)
On are 20 DNA-Damage-Inducible Transcript 3 (DDIT3) Proteins from 10 different suppliers available. Additionally we are shipping DDIT3 Antibodies (199) and DDIT3 Kits (30) and many more products for this protein. A total of 263 DDIT3 products are currently listed.
CEBPZ, CHOP, CHOP-10, Chop10, GADD153, Xchop
list all proteins Gene Name GeneID UniProt
DDIT3 13198 P35639
DDIT3 29467  
DDIT3 1649 P35638

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DDIT3 Proteins (DDIT3) by Origin

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Top referenced DDIT3 Proteins

  1. Human DDIT3 Protein expressed in Escherichia coli (E. coli) - ABIN667718 : Oyadomari, Mori: Roles of CHOP/GADD153 in endoplasmic reticulum stress. in Cell death and differentiation 2004 (PubMed)
    Show all 2 references for ABIN667718

More Proteins for DDIT3 Interaction Partners

Mouse (Murine) DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. Deletion of CHOP attenuates dysfunction of the autophagy/lysosomal pathway in beta-cells of transgenic mice.

  2. Interference with DOT1L (show DOT1L Proteins) activity resulted in transcriptional activation of Atf4 (show ATF4 Proteins) and Ddit3 accompanied by decreased levels of H3K79 dimethylation.

  3. this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK (show EIF2AK3 Proteins) and a downstream effector of its activation, CHOP, in tubule cell production of fibronectin (show FN1 Proteins)

  4. CHOP regulates not only apoptosis-related signaling but also ROS (show ROS1 Proteins) formation and inflammation in renal tubular cells during ischemia/reperfusion (I/R). CHOP may play an important role in the pathophysiology of I/R-induced renal injury.

  5. As a dual function cytokine, IL-1alpha may contribute to the induction of CHOP intracellularly, while IL-1alpha released from necrotic cells accelerates steatohepatitis via induction of inflammatory cytokines by neighboring cells.

  6. TFEB (show TFEB Proteins)-regulated signaling pathway for osteoblast differentiation is involved in ATF4 (show ATF4 Proteins)/CHOP-dependent signaling pathway.

  7. CHOP expression in myeloid cells plays an important role in determining the magnitude and duration of inflammatory response in vivo by modulating expression of proinflammatory cytokines such as IL-6 (show IL6 Proteins) in infiltrating macrophages.

  8. the ER stress-induced transcription factor, CHOP, at least in part, plays an important role in the development of bleomycin-induced pulmonary fibrosis

  9. Data indicate that transcription factor Chop does not play a significant causal role during retinal degeneration.

  10. Upregulation of PD-1 (show PDCD1 Proteins) and PD-L1 (show CD274 Proteins) was associated with marked increases in GADD153 during myocardial ischemic reperfusion injury.

Human DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. plasma exposure resulted in expression of unfolded protein response (UPR) proteins such as glucoserelated protein 78 (GRP78 (show HSPA5 Proteins)), protein kinase (show CDK7 Proteins) R (PKR (show PKLR Proteins))like ER kinase (PERK (show EIF2AK3 Proteins)), and inositolrequiring enzyme 1 (IRE1 (show ERN1 Proteins)). Elevated expression of spliced Xbox binding protein 1 (XBP1 (show XBP1 Proteins)) and CCAAT/enhancerbinding protein homologous protein (CHOP) further confirmed that ROS (show ROS1 Proteins) generatedby NTGP induces apoptosis through the ER stress

  2. High DDIT3 expression is associated with non-small-cell lung cancer.

  3. CAPE/TRAIL stimulated apoptosis through the binding of TRAIL to DR5 (show TNFRSF10B Proteins). Moreover, expression of transcription factor C/EBP homologous protein (CHOP) markedly increased in response to CAPE and transient knockdown of CHOP abolished CAPE/TRAIL-mediated apoptosis.

  4. the C/EBPD (show CEBPD Proteins) binding site is required for RU486-mediated activation of the CHOP promoter.

  5. Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Proteins) formation upstream of AMP-activated protein kinase (show PRKAA2 Proteins) and protein kinase (show CDK7 Proteins) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein pathways and p21 Cip1 (show CDKN1A Proteins) expression.

  6. Data suggest that HOXA-AS2 (show ARSA Proteins) could be an oncogene (show RAB1A Proteins) for GC partly through suppressing P21 (show CDKN1A Proteins), PLK3 (show PLK3 Proteins), and DDIT3 expression.

  7. FUS (show FUS Proteins)-DDIT3 is uniquely regulated at the transcriptional as well as the post-translational level and that its expression level is important for myxoid liposarcoma tumour development.

  8. CGK733-induced intracellular calcium sequestration in pancreatic tumor cells is correlated with the PERK (show EIF2AK3 Proteins)/CHOP signaling pathway and may also be involved in the dysregulations of calcium-binding proteins.

  9. Combined administration inhibited the cells most potently and time-dependently, decreased the expression of HO-1 (show HMOX1 Proteins), and significantly increased the expression of ATF4 (show ATF4 Proteins), CHOP, and Ire-1 (show ERN1 Proteins) proteins expression levels

  10. Blockage of PERK (show EIF2AK3 Proteins) signaling expression by siRNA not only significantly reduced the expression of CHOP.

Xenopus laevis DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. CHOP (GADD153) is an inhibitor of Wnt (show WNT2 Proteins)/TCF (show HNF4A Proteins) signals

DDIT3 Protein Profile

Protein Summary

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Alternative names and synonyms associated with DDIT3

  • DNA-damage-inducible transcript 3 (ddit3)
  • DNA-damage inducible transcript 3 (Ddit3)
  • DNA-damage-inducible transcript 3 (DDIT3)
  • DNA-damage-inducible transcript 3 (Ddit3)
  • DNA-damage-inducible transcript 3 (LOC100338439)
  • CEBPZ protein
  • CHOP protein
  • CHOP-10 protein
  • Chop10 protein
  • GADD153 protein
  • Xchop protein

Protein level used designations for DDIT3

C/EBP homoologous protein 10 , C/EBP zeta , CCAAT/enhancer-binding protein homologous protein , DDIT-3 , DNA damage-inducible transcript 3 protein , c/EBP-homologous protein 10 , growth arrest and DNA-damage-inducible protein GADD153 , C/EBP homologous protein , growth arrest and DNA damage-inducible protein GADD153 , growth arrest and DNA damage-inducible , transcription factor GADD153 , C/EBP-homologous protein 10 , DNA-damage inducible transcript 3

733816 Xenopus (Silurana) tropicalis
13198 Mus musculus
29467 Rattus norvegicus
1649 Homo sapiens
398615 Xenopus laevis
777788 Bos taurus
607439 Canis lupus familiaris
100857832 Gallus gallus
101787388 Cavia porcellus
100240743 Sus scrofa
100338439 Oryctolagus cuniculus
541600 Ovis aries
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