Browse our anti-DMPK (DMPK) Antibodies

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anti-Dystrophia Myotonica-Protein Kinase Antibodies (DMPK)
On are 78 Dystrophia Myotonica-Protein Kinase (DMPK) Antibodies from 17 different suppliers available. Additionally we are shipping DMPK Proteins (12) and DMPK Kits (4) and many more products for this protein. A total of 101 DMPK products are currently listed.
list all antibodies Gene Name GeneID UniProt
DMPK 1760 Q09013
DMPK 13400 P54265
DMPK 308405  

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Top referenced anti-DMPK Antibodies

  1. Human Monoclonal DMPK Primary Antibody for IF, WB - ABIN968595 : Jin, Shimizu, Balasubramanyam, Epstein: Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells. in Cell motility and the cytoskeleton 2000 (PubMed)
    Show all 3 references for 968595

  2. Cow (Bovine) Polyclonal DMPK Primary Antibody for IHC, WB - ABIN2775281 : Ramasamy, Ren, Mench, Regan: Impact of initial biofilm growth on the anode impedance of microbial fuel cells. in Biotechnology and bioengineering 2008 (PubMed)
    Show all 2 references for 2775281

  3. Human Polyclonal DMPK Primary Antibody for ELISA, WB - ABIN1533843 : Fu, Pizzuti, Fenwick, King, Rajnarayan, Dunne, Dubel, Nasser, Ashizawa, de Jong: An unstable triplet repeat in a gene related to myotonic muscular dystrophy. in Science (New York, N.Y.) 1992 (PubMed)
    Show all 2 references for 1533843

More Antibodies against DMPK Interaction Partners

Human Dystrophia Myotonica-Protein Kinase (DMPK) interaction partners

  1. Our work suggests that DM1 patients are at risk for Fuchs' endothelial corneal dystrophy (FECD (show COL8a2 Antibodies)). DMPK mutations contribute to the genetic burden of FECD (show COL8a2 Antibodies) but are uncommon. We establish a connection between two repeat expansion disorders converging upon RNA-MBNL1 (show MBNL1 Antibodies) foci and FECD (show COL8a2 Antibodies).

  2. findings thus suggest that nuclear retention may be a common feature of regulation of DMPK RNA expression. The typical forced nuclear residence of expanded DMPK transcripts affects this regulation in tissues of DM1 patients, but not through hyperadenylation.

  3. Data, including data from studies on synthetic RNA modeling RNA repeat expansions found in patients with Huntington's disease (mRNA for exon 1 of Huntingtin (show HTT Antibodies) protein) and myotonic dystrophy type 1 (mRNA for 3prime untranslated region of dystrophia myotonica-protein kinase), suggest internal loops of r(3xCAG) are stabilized by one-hydrogen bond AA pairs, while those of r(3xCUG) prefer one- or two-hydrogen bond UU pairs.

  4. Analysis of five intergenerational transmissions revealed a substantial intrafamilial stability of the DM1 mutation among relatives.

  5. Methylation upstream of the expanded DMPK CTG repeat occurs exclusively with maternal transmission and that it is somehow linked to the development of congenital myotonic dystrophy.

  6. Study shows DMPK expression with a complex pattern of tissue-specific epigenetics consistent with evidence that normal tissue require careful regulation of its RNA and protein levels which might include cis (show CISH Antibodies)-acting regulatory elements in neighboring genes.

  7. Sense DMPK RNA foci clearly co-localize with MBNL1 (show MBNL1 Antibodies) and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  8. miR (show MLXIP Antibodies)-206 and miR (show MLXIP Antibodies)-148a regulate the DMPK transcript and may functionally cooperate.

  9. In conclusion, our data suggest that the frequency of DMPK mutation carriers and the prevalence of DM1 in the Korean population might be higher than those reported in other ethnicities. Supporting

  10. The results show that a DEAD-box helicase, DDX6 (show DDX6 Antibodies), interacts with CUG-expanded DMPK-mRNA in primary fibroblasts from dystrophia myotonica type 1 patients.

Mouse (Murine) Dystrophia Myotonica-Protein Kinase (DMPK) interaction partners

  1. Our results support the feasibility and safety of using antisense oligonucleotides for post-transcriptional silencing of DMPK in muscle and heart.

  2. Sense DMPK RNA foci clearly co-localize with MBNL1 (show MBNL1 Antibodies) and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  3. The data of this study demonstrated that DMPK knockout mice present altered beta-agonist-induced responses and suggest that this is due, at least in part, to a reduced density of beta(1)-adrenergic receptors in cardiac plasma membranes.

  4. Cytosolic DMPK participates in remodeling of the actomyosin cytoskeleton in developing skeletal muscle cells.

  5. Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy

  6. a tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis

  7. Dmpk deficiency results in a sodium (Na) channel abnormality comprising frequent, long bursts of Na channel reopenings during sustained depolarization resulting in a plateau of non-inactivating late Na current.

  8. DMPK has a modulatory role in the control of intracellular Ca2 (show CA2 Antibodies)+ concentration in mouse ventricular cardiomyocytes, loss of which contributes to cardiac dysfunction in myotonic dystrophy.

  9. role for DMPK in synaptic plasticity that could be relevant to the cognitive dysfunction associated with myotonic dystrophy

  10. DMPK isoforms have cell-type and location dependent substrate specificities with a role in organellar and cytoarchitectural dynamics

DMPK Antigen Profile

Antigen Summary

The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Alternative names and synonyms associated with DMPK

  • dystrophia myotonica-protein kinase (DMPK) antibody
  • dystrophia myotonica-protein kinase (Dmpk) antibody
  • DM antibody
  • DM1 antibody
  • DM1PK antibody
  • Dm15 antibody
  • DMK antibody
  • DMPK antibody
  • MDPK antibody
  • MT-PK antibody

Protein level used designations for DMPK

dystrophia myotonica-protein kinase , myotonic dystrophy protein kinase , myotonin-protein kinase-like , DM protein kinase , DM-kinase , DM1 protein kinase , myotonic dystrophy associated protein kinase , myotonin protein kinase A , myotonin-protein kinase , thymopoietin homolog , dystrophia myotonica kinase, B15

456139 Pan troglodytes
715328 Macaca mulatta
100434494 Pongo abelii
100617691 Monodelphis domestica
1760 Homo sapiens
13400 Mus musculus
308405 Rattus norvegicus
484436 Canis lupus familiaris
513675 Bos taurus
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