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Browse our FMR1 Proteins (FMR1)

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Fragile X Mental Retardation 1 Proteins (FMR1)
On are 7 Fragile X Mental Retardation 1 (FMR1) Proteins from 5 different suppliers available. Additionally we are shipping FMR1 Antibodies (176) and FMR1 Kits (5) and many more products for this protein. A total of 194 FMR1 products are currently listed.
AT24755, BcDNA:GM08679, cg6203, dfmr, dfmr1, dFmrp, dfxr, dfxr1, dFXRP, Dmel\\CG6203, dmfr1, EP(3)3517, fmr, Fmr-1, fmr1, Fmrp, FRAXA, FXR, POF, POF1, zFMR1
list all proteins Gene Name GeneID UniProt
FMR1 2332 Q06787
FMR1 24948 Q80WE1
FMR1 14265  

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FMR1 Proteins (FMR1) by Origin

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More Proteins for FMR1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. dFMRP cooperates with Piwi in maintaining genome integrity by silencing heterochromatic genes and suppressing transposon expression.

  2. results show Fragile X Mental Retardation Protein (FMRP) shapes neuron class-specific calcium signaling in excitatory vs. inhibitory neurons in developing learning/memory circuitry, and that FMRP mediates activity-dependent regulation of calcium signaling specifically during the early-use critical period.

  3. results support a model whereby dFMRP can modulate the neurotoxicity caused by TDP-43 (show TARDBP Proteins) overexpression

  4. demonstrate that Zfrp8 genetically interacts with Fmr1 and tral (show LSM14A Proteins) in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways

  5. dFmr1 protein is essential for proper cardiac function and establish the fly as a new model for studying the role(s) of FraX proteins in the heart.

  6. These results show that dfmr1 acts in a neuron type-specific activity-dependent manner for sculpting dendritic arbors during early-use, critical period development of learning and memory circuitry in the Drosophila brain.

  7. upon the stimulation of replication stress, dFMR1 is associated with chromatin in a domain-specific manner, which is essential for its ability to induce the phosphorylation of H2Av (show H2AFV Proteins).

  8. FMRP inhibits translation by binding directly to the L5 protein on the 80S ribosome.

  9. FMRP negatively regulates HSPG (show SDC2 Proteins) co-receptors controlling trans-synaptic signaling during synaptogenesis

  10. FMRP and Ataxin-2 (show ATXN2 Proteins) have roles in long-term olfactory habituation and neuronal translational control

Human Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. data provide evidence that the CGG-repeat numbers below 26 or above 34 of FMR1 gene are also associated with disease risks

  2. unlike MutSbeta, MutSalpha may also act to protect against repeat contractions in the Fmr1 gene

  3. One third of the putative mRNA targets described for FMRP appear to be transported in granules and FMRP is more abundant in granules than in polyribosomes. This observation supports a primary role for FMRP in granules biology.

  4. FMR1 gene mutation is associated with fragile X syndrome.

  5. This large study did not demonstrate any substantial association between normal-range FMR1 repeat lengths and reproductive parameters

  6. FMR1 is a highly conserved gene whose interpretation and effect on outcomes remains controversial in the reproductive health setting. Recent re-evaluations of the commonly accepted normal range have yielded interesting tools for possibly explaining unexpected outcomes in assisted reproduction

  7. Our results indicate that there is a potential association between FMR1 intermediate expanded alleles and Parkinson disease.

  8. FMR1 Gene Missense SNPs

  9. Data show that CGG repeats within the testes of a fetus carrying a full Fragile X syndrome (FXS) mutation and another fetus carrying mosaicism FXS mutation in fragile X mental retardation 1 protein (FMR1).

  10. Despite increasing use, FMR1 CGG repeats in the normal range cannot be used as a predictor of ovarian response to gonadotrophin stimulation

Zebrafish Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. We identified thousands of clustered RNA editing sites in the zebrafish transcriptome and showed that Fmrp biochemically interacts with the Adar2a protein. The expression levels of the adar (show ADAR Proteins) genes and Adar2 (show ADARB1 Proteins) protein increased in fmr1-/- zebrafish

  2. Loss-of-function fmr1 mutants carrying an anti-fmr1 miRNA transgene show abnormal neuronal morphology and connectivity similar to that seen in human fragile X syndrome.

Mouse (Murine) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. One third of the putative mRNA targets described for FMRP appear to be transported in granules and FMRP is more abundant in granules than in polyribosomes. This observation supports a primary role for FMRP in granules biology.

  2. Study showed that Fmr1 knock-out astrocytes affect the dendritic arborization of all subtypes of hippocampal neurons and that select populations of hippocampal neurons are more effected by this astrocyte-mediated developmental delay; specifically, the stellate neurons grown on Fmr1 knock-out astrocytes exhibit the most pervasive developmental delays

  3. The data reveal an age-dependent deficit in long-term potentiation in Fmr1KO mice, which may correlate to some of the complex age-related deficits in Fragile X syndrome.

  4. increased white matter seen in the FMR1-KO-FVB could be highlighting a structural over-connectivity, which could lead to some of the behavioral abnormalities seen with the FMR1-KO-FVB mice

  5. Study shows deficits in habituation of neural responses to repeated sounds in the Fragile X Mental Retardation gene (Fmr1) KO mice as seen in humans with fragile X syndrome.

  6. we find abnormal patterns of coupling between theta and gamma oscillations in perisomatic and dendritic hippocampal CA1 (show CA1 Proteins) local field potentials of the Fmr1 knockout mice.

  7. This study demonstrated that in the active phase of the circadian cycle, Fmr1 KO mice are hyperactive, and demonstrate reduced anxiety and impaired learning and memory.

  8. Study reveals a mechanism for the local regulation of translation by miR (show MLXIP Proteins)-181d and FMRP during axon development.

  9. Results indicate that, while the fragile X (Fmr1) mouse model effectively recapitulates many molecular and cellular aspects of fragile X syndrome, the cognitive profile of Fmr1 mice generally does not recapitulate the primary cognitive deficits in the human syndrome, even when diverse and challenging tasks are imposed.

  10. the absence of fragile X mental retardation protein (show NUFIP2 Proteins) has divergent effects on the function of individual types of ion channels not only between brain regions

FMR1 Protein Profile

Protein Summary

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

Alternative names and synonyms associated with FMR1

  • CG6203 gene product from transcript CG6203-RC (Fmr1)
  • fragile X mental retardation 1 (FMR1)
  • fragile X mental retardation 1 (Fmr1)
  • fragile X mental retardation 1 (fmr1)
  • fragile X mental retardation syndrome 1 (Fmr1)
  • AT24755 protein
  • BcDNA:GM08679 protein
  • cg6203 protein
  • dfmr protein
  • dfmr1 protein
  • dFmrp protein
  • dfxr protein
  • dfxr1 protein
  • dFXRP protein
  • Dmel\\CG6203 protein
  • dmfr1 protein
  • EP(3)3517 protein
  • fmr protein
  • Fmr-1 protein
  • fmr1 protein
  • Fmrp protein
  • FRAXA protein
  • FXR protein
  • POF protein
  • POF1 protein
  • zFMR1 protein

Protein level used designations for FMR1

CG6203-PA , CG6203-PB , CG6203-PC , CG6203-PD , CG6203-PE , CG6203-PF , CG6203-PG , CG6203-PH , CG6203-PI , Fmr1-PA , Fmr1-PB , Fmr1-PC , Fmr1-PD , Fmr1-PE , Fmr1-PF , Fmr1-PG , Fmr1-PH , Fmr1-PI , Fragile-X mental retardation protein , Fragile-X-related , dFmr1 , drosophila fragile X mental retardation protein , fragile X , fragile X mental retardation , fragile X mental retardation 1 , fragile X mental retardation gene , fragile X mental retardation protein , fragile X protein , fragile X related protein , fragile X-related , fragile x related , fragile-X , fragile X mental retardation protein 1 , fragile X mental retardation protein 1 homolog , fragile X mental retardation syndrome 1 homolog , fragile X mental retardation-1 protein , protein FMR-1 , ragile X mental retardation protein , fragile X mental retardation 1 protein , FMRP , mFmr1p

37528 Drosophila melanogaster
465894 Pan troglodytes
2332 Homo sapiens
481070 Canis lupus familiaris
24948 Rattus norvegicus
259191 Danio rerio
422395 Gallus gallus
100155078 Sus scrofa
507482 Bos taurus
100172902 Pongo abelii
14265 Mus musculus
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