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Human GREM1 ELISA Kit for Sandwich ELISA - ABIN417852
Wellbrock, Harbaum, Stamm, Hennigs, Schulz, Klose, Bokemeyer, Fiedler, Lüneburg: Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension. in Lung 2015
Show all 7 Pubmed References
Mouse (Murine) GREM1 ELISA Kit for Sandwich ELISA - ABIN1115260
Siddique, Curran, Ghayur, Liu, Shi, Hoff, Gangji, Brimble, Margetts: Gremlin promotes peritoneal membrane injury in an experimental mouse model and is associated with increased solute transport in peritoneal dialysis patients. in The American journal of pathology 2014
FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 (show BMP4 ELISA Kits) transcription, and activation of bmp antagonists, nog2 and grem1a.
Results suggest that the negative regulatory loops between BMP/Tbx2 (show TBX2 ELISA Kits) and Gremlin or Hey1 (show HEY1 ELISA Kits) are responsible for defining the territory of the pronephric nephron.
Gremlin encodes a maternal transcript, and the zygotic transcription is turned on at the mid-blastula transition.
Wild-type gremlin is able to bind broadly across the various regions of kidney in an heparin sulfate-dependent manner, with particularly intense binding to tubular structures in the renal cortex. In a model of chronic kidney disease, fibrotic changes in the kidney result in a loss of gremlin binding sites. Gremlin mutants with reduced affinity for heparin showed negligible binding under the same conditions.
involved in regulation of bone morphogenetic protein activities in cartilage tissues in the adult skeleton
Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA (show SMN1 ELISA Kits), and COL1a1 (show COL1A1 ELISA Kits) expression in a liver fibrosis disease model.
Grem1 expression in the tubular epithelial compartment plays a significant role in the fibrotic response to renal injury in vivo.
Gremlin-1 protein expression was detected specifically in the lung after birth and did not result in any signs of respiratory insufficiency. CXCL10 chemokine le (show CXCL10 ELISA Kits)vels correlate negatively with gremlin-1 levels in mouse and human lung.
Data show that parathyroid hormone-related protein (PTHrP (show PTHLH ELISA Kits)) regulates gremlin levels in pancreatic acinar and stellate cells.
Gremlin is a key pro-fibrogenic factor in chronic pancreatitis
Gremlin/VEGFR2 (show KDR ELISA Kits) axis participates in renal inflammation and could be a novel target for kidney disease.
GREM1 induces fibrosis and angiogenesis in mouse peritoneum and is associated with increased solute transport in peritoneal dialysis patients.
Grem1 expression identifies distinct connective tissue stem cells in both the bone (osteochondroreticular stem cells) and the intestine (reticular stem cells).
Wattles in goats are associated with the FMN1 (show FMN1 ELISA Kits)/GREM1 region on chromosome 10
Gene duplication upstream of GREM1 was screened for in all sixty-five SPS (show SMS ELISA Kits) individuals with no carriers being identified.
Nox1 (show NOX1 ELISA Kits)-SHH (show SHH ELISA Kits)-Grem1 signaling axis in pulmonary vascular endothelium that is likely to contribute to Pulmonary hypertension.
GREM1 plays an important role in the development of glioma, and it may serve as a potential target in glioma therapy.
Describe a hereditary mixed polyposis syndrome in which is characterized by SCG5 (show SCG5 ELISA Kits)-GREM1 duplication.
GREM1 is frequently expressed by myofibroblasts in scars or in the stroma of basal cell carcinomas, suggesting that GREM1 expression can be a marker for activated myofibroblasts in the cancer stroma or in scar tissue.
Clinical features of hereditary mixed polyposis syndrome caused by GREM1 gene duplication include extracolonic tumors, onset of polyps in adolescence, and rapid progression of some polyps to advanced adenomas.
In human Idiopathic Pulmonary Fibrosis patient samples the study established a strong negative correlation in the mRNA expression levels of gremlin-1 and CXCL10 (show CXCL10 ELISA Kits). The results suggest that in addition to regulation of epithelial-mesenchymal crosstalk during tissue injury, gremlin-1 modulates inflammatory cell recruitment and anti-fibrotic chemokine (show CCL1 ELISA Kits) production in the lung.
The results suggest that inhibition of BMP-2 by Gremlin-1 occurs by a mechanism that is distinct from other known inhibitors such as Noggin and Chordin and study propose a novel model of BMP-2-Gremlin-1 interaction yet not seen among any BMP antagonists, and cannot rule out that several different oligomeric states could be found, depending on the concentration of the two proteins.
Gremlin1 inhibited the cell viability and osteogenic differentiation of human mesenchymal stem cells (MSCs) and the suppression of gremlin1 expression can increase the cell viability and osteogenic differentiation of human MSCs induced by BMP-2 (show BMP2 ELISA Kits).
overexpression of GREM1 in mesenchymal stem cells have greater therapeutic effects against ischemia.
both the regenerating and contralateral, developing limb of grem1 transgenics developed skeletal defects, suggesting that overexpressing grem1 negatively affects limb patterning
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
gremlin 1 homolog a, cysteine knot superfamily
, gremlin 1 homolog, cysteine knot superfamily
, gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
, gremlin 1
, cysteine knot superfamily 1
, cysteine knot superfamily 1, BMP antagonist 1
, down-regulated in Mos-transformed cells protein
, down-regulated in v-mos-transformed cells
, gremlin 1, cysteine knot superfamily, homolog
, Cysteine knot superfamily 1, BMP antagonist 1
, DAN domain family member 2
, cell proliferation-inducing gene 2 protein
, gremlin 1-like protein
, increased in high glucose-2