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Loss of Myf5 function results in a cascade effect that begins with abnormal formation of the dorsal organizer during gastrulation, causing defects in myf5-knockdown embryos
the secreted ligand Dkk3a binds to the membrane receptor Itgalpha6b, which increases the protein level of phosphorylated p38a (show MAPK14 Proteins) and activates myf5 promoter activity of zebrafish embryos during myogenesis.
a novel intronic microRNA, miR (show MYLIP Proteins)-In300, which is derived from I300 of the first intron of zebrafish myf5, enables significant repression of myf5 promoter activity through silencing the long isoform of the Dickkopfs-3 gene.
A novel regulatory base sequence functions as a key element to drive the somite-specificity of myf-5.
Functional analysis of intron 1 showed a strong, negative, cis (show CISH Proteins)-regulatory element located at +502/+835, and this is the first study to identify a novel, cis (show CISH Proteins)-acting silencer that is crucial to negatively regulating myf-5 expression.
Foxd3 (show FOXD3 Proteins), a well-known regulator in neural crest development, is also involved in myf5 regulation
Myf5 and Myod (show MYOD1 Proteins) function independently during cranial myogenesis.
cell lineage-specific expression of myf5 is delicately orchestrated by multiple modules within the distal upstream region. This study provides an insight to understand the molecular control of myf5 and myogenesis in the zebrafish.
Pitx2c (show PITX2 Proteins) expression is reactivated, while expression of Myf5 is downregulated in human systolic heart failure as determined by qRT-PCR and Western blot analyses.
results are the first demonstration of a myogenic conversion of human mesenchymal and endothelial cells by Myf5
DUX4c induces the MYF5 protein and myoblast proliferation, and has a role in facioscapulohumeral muscular dystrophy
The myogenic basic helix-loop-helix family of transcription factors, MyoD (show MYOD1 Proteins), Myf5, myogenin (show MYOG Proteins), and MRF4 (show MYF6 Proteins), can each activate the muscle differentiation program.
Mrf4 (show MYF6 Proteins) expression precedes or is contemporaneous with that of Myf5, suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis
Myogenin (show MYOG Proteins) and myogenic differentiation factor D (MyoD (show MYOD1 Proteins)) mRNAs increased (P < 0.05) in young and old, whereas myogenic factor (show MYOG Proteins) (myf)-5 mRNA increased in young only (P < 0.05). Myf-6 (show MYF6 Proteins) protein increased (P < 0.05) in both young and old.
A novel homozygous polymorphism that prevented the binding of MYF-5 to FOXE1 (show FOXE1 Proteins) promoter and affected the FOXE1 (show FOXE1 Proteins) expression was found in 45% nonsyndromic cleft palate.
The effects of myostatin (show MSTN Proteins) and myogenic factor 5 polymorphisms on growth and muscle traits of Marchigiana breed were assessed.
Bos taurus MYF5 activates MYF5 and MYOD1 (show MYOD1 Proteins) expression in cultured fibroblasts.
A polymorphism showed an influence on Myf5 gene expression in the longissimus dorsi muscle
results suggest that MyoD and Myf5 influence the MyHC isoform expression, although the effects are not decisive in specifying the phenotypes of adult muscles
Novel RNA-binding activity of MYF5 enhances Ccnd1 (show CCND1 Proteins) mRNA translation during myogenesis.
Transcription of the skeletal muscle program is achieved by the expression of MyoD (show MYOD1 Proteins), which binds to the same sites as Myf5, indicating that each factor regulates distinct steps in gene initiation and transcription at a shared set of binding sites
The Myf5- and Myogenin (show MYOG Proteins)-deficient mice showed a partial or complete, respectively, loss of TMC (show STT3A Proteins) in an otherwise regularly structured thymus.
Elimination of Myf5(Cre)-DTA cells on a Myod (show MYOD1 Proteins) null background did not result in the total absence of skeletal muscles
A muscle-specific (show EIF3K Proteins) regulatory element of p57(kip2 (show CDKN1C Proteins)) directly activated by muscle regulatory factors in myoblasts but repressed by the Notch (show NOTCH1 Proteins) targets Hes1/Hey1 (show HEY1 Proteins) in progenitor cells, is identified.
lineage tracing based on multiple reporter lines has demonstrated that regardless of common ancestral expression of Myf5, there is a clear distinction between periocular myogenic and non-myogenic cell lineages
The results demonstrate the heterogeneity and functional differences of the Myf5- and non-Myf5-lineage cells in the white adipose tissue.
Adult satellite cells derive from progenitors that first express the myogenic determination gene Myf5 during fetal stages of myogenesis.
Direct molecular regulation of the myogenic determination gene Myf5 by Pax3 (show PAX3 Proteins), with modulation by Six1 (show SIX1 Proteins)/4 factors, is exemplified by the -111 kb-Myf5 enhancer
The observations provide a mechanism linking Myf5 levels to muscle stem cell heterogeneity and fate by exposing two distinct and opposing phenotypes associated with Myf5 haploinsufficiency.
myf5 upregulation can be a good criterion for the activation of adult myogenesis during X. laevis metamorphosis
During early Xenopus development Myf5 protein regulates a distinct myogenic program.
FGF8 (show FGF8 Proteins), Wnt8 (show WNT8A Proteins) and Myf5 are target genes of Tbx6 (show TBX6 Proteins) during anteroposterior specification in Xenopus embryo
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
myogenic regulatory factor 5
, myogenic factor 5
, MyoD family
, myogenic factor-5
, basic helix-loop-helix nuclear protein
, class C basic helix-loop-helix protein 2
, Myf5 homolog
, myogenic regulatory factor MYF-5
, myogenic factor Xmyf-5