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these data elucidated that a GSK3beta-FBXW7beta-dependent mechanism controls SETD3 protein levels during the cell cycle and attenuates its oncogenic role in liver tumorigenesis.
Results show that high expression levels of SMYD2 (show SMYD2 Proteins), SETD3, and NO66 (show C14orf169 Proteins) in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival.
MAF1 (show MAF1 Proteins), RNF7 (show RNF7 Proteins) and SETD3 are identified as PCNA (show PCNA Proteins)-associated proteins in human cells and given this interaction with PCNA (show PCNA Proteins), Maf1 (show MAF1 Proteins), RNF7 (show RNF7 Proteins), and SetD3 are potentially involved in DNA replication, DNA repair, or associated processes.
SETD3 is a H3K4/K36 (show KRT36 Proteins) methyltransferase and plays an important role in the transcriptional regulation of muscle cell differentiation
Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation (By similarity).
SET domain-containing protein 3
, histone-lysine N-methyltransferase setd3
, endothelial differentiation inhibitory protein D10