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Nuclear expression of SOX18 (show SOX18 Proteins) was shown in vascular endothelial cells, basal layer cells of NS epidermis, as well as in AK, BCC and SCC (show CYP11A1 Proteins) cancer cells
In non-small cell lung cancer, SOX8 expression was elevated, and correlated with tumor size, lymph node metastasis, clinical stage and differentiation classification.
Suggest that miRNA-124 may regulate non-small cell lung carcinoma cell proliferation via decreasing SOX8.
SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells.
SOX8 promotes cancer cell proliferation and its expression is correlated with elevated beta-catenin (show CTNNB1 Proteins) levels in hepatocellular carcinoma
The SOX8 single nucleotide polymorphism, rs2744148, is associated with increased genetic risk for multiple sclerosis.
Quantitative changes of enteric glia represented by SOX8 provide a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut (show GUSB Proteins).
SOX2 (show SOX2 Proteins) and SOX17 (show SOX17 Proteins) expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful.
These results suggest that Sox8 is essential in Sertoli cells for germ cell differentiation, partly by controlling the microenvironment of the seminiferous epithelium.
combined RNA profiling signals, motif predictions and network data identified putative SOX8/SOX9 (show SOX9 Proteins) target genes in Sertoli cells and yielded insight into regulatory interactions that depend upon these transcription factors
Sox9 (show SOX9 Proteins) and Sox8 maintain integrity of the basal lamina to prevent testis cord disintegration and both factors actively suppress the ovarian program during early testis development.
Seven regions near the Sox8 gene as potential enhancers, were identified.
SOX8 has a role in testis differentiation in mice and synergizes with SF1 (show SF1 Proteins) to activate the Amh (show AMH Proteins) promoter in vitro
Sox8 acts as a specific negative regulator of skeletal muscle differentiation, possibly by interfering with the function of myogenic basic helix-loop-helix proteins
Results suggest that Sox8 reinforces Sox9 (show SOX9 Proteins) function in testis differentiation of mice.
Sox8-deficient mice thus exhibited a similar, but less severe phenotype than did Sox10 (show SOX10 Proteins)-deficient mice wiwth regard to oligodendrocyte differentiation.
The defects in enteric nervous system development of mice with Sox10 (show SOX10 Proteins) and Sox8 mutations are caused by a reduction of the pool of undifferentiated vagal neural crest cells.
Sox8 is a negative regulator of osteoblast differentiation.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
transcription factor SOX-8
, SRY-box containing gene 8
, transcription factor Sox-8
, SOX8 transcription factor