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using in vitro prolactin induced lactogenic differentiation in an HC11 mouse cell model and an in vivo conditional knockout mouse model we showed that mouse Zfhx3 is essential for mouse mammary epithelial cell differentiation and mouse mammary gland development at the lactation stage through regulation of prolactin receptor expression and the downstream Jak2-Stat5 signaling pathway.
Increasing experimental data support that ZFHX3 gene plays a critical role in the pathogenesis of atrial fibrillation where it was found up-regulated. [review]
We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for atrial fibrillation (A)F and AF-related phenotypes.
Nuclear localization of AT-motif binding factor 1 (ATBF1) indicates better prognosis of urothelial carcinoma.
Cellular localization of ATBF1 is correlated with its function in breast cancer. Nuclear ATBF1 was co-localized with chromosome during mitosis normally. Estrogen induced translocation of cytoplasmic ATBF1 to nuclei in MCF7.
The results suggest an additive effect of ZFHX3 and PTEN deletions on the development and progression of prostate neoplasia
Both ZFHX3 and PITX2c (show PITX2 ELISA Kits) regulate expression of NPPA (show NPPA ELISA Kits), TBX5 (show TBX5 ELISA Kits) and NKX2.5 (show NKX2-5 ELISA Kits).
In a Caucasian population, genetic variant rs7193343 SNP in ZFHX3 gene is associated with risk of atrial fibrillation.
Study found increased levels of ATBF1 in the cytoplasm of hippocampal pyramidal neurons in Alzheimer's disease brains and that ATBF1 binds to the C-terminal of A-beta (show SUCLA2 ELISA Kits)-PP, increasing the steady state levels of A-beta (show SUCLA2 ELISA Kits)-PP and resulting in increased A-beta (show SUCLA2 ELISA Kits) production
The CAA (show TSHZ1 ELISA Kits) repeat polymorphism in exon 9 of the ZFHX3 gene contributes to the Coronary heart disease susceptibility in the Chinese population.
ZFHX3 knock-down in atrial myocytes dysregulated calcium homeostasis and increased atrial arrhythmogenesis.
Data show that knock-out of zinc finger homeobox 3 (ZFHX3) interrupted lactogenesis, resulting in underdeveloped glands.
These findings provide in vivo evidence that ATBF1 is a tumor suppressor in the prostate
These data indicate that tachypacing decreased ATBF1, leading to enhanced STAT3 (show STAT3 ELISA Kits) DNA-binding activity due to the reduced formation of a binary complex of ATBF1 and PIAS3 (show PIAS3 ELISA Kits).
findings indicate that Atbf1 plays a role in the development of pubertal mammary gland likely by modulating the function of estrogen-ER signaling in luminal cells and by modulating gene expression in basal cells
Atbf1 heterozygous mice displayed reduced body weight, preweaning mortality, increased cell proliferation, and attenuated cytokeratin 18 (show KRT18 ELISA Kits) expression, indicating haploinsufficiency of Atbf1.
these results demonstrate that these phosphorylation sites on ATBF1 function as a defensive shield to calpain-1 (show CAPN1 ELISA Kits).
A novel signaling pathway that links ATM (show ATM ELISA Kits) via CREB (show CREB1 ELISA Kits) to the transcription factor ZFHX3, which in turn promotes survival of neurons by inducing expression of platelet-derived growth factor receptor beta (show PDGFRB ELISA Kits), is reported.
Atbf1, serves as a novel pituitary regulator for one of the two required enhancers as shown by genetic and in vitro analysis
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene.
zinc finger homeobox 3
, zinc finger homeobox protein 3-like
, AT-binding transcription factor 1
, AT-binding transcription factor1
, AT motif-binding factor 1
, alpha-fetoprotein enhancer binding protein
, alpha-fetoprotein enhancer-binding protein
, zinc finger homeobox protein 3
, zinc finger homeodomain protein 3
, AT motif binding factor 1
, AT motif-binding factor