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Lack of Dicer leads to oxidative stress, cytosolic acidification, upregulated NHE1 (show SLC9A1 ELISA Kits) expression and activity as well as swelling of CD4 (show CD4 ELISA Kits)+ T cells, functions all reversed by miR (show MLXIP ELISA Kits)-15b or miR (show MLXIP ELISA Kits)-200b.
Results show that elevated miR (show MLXIP ELISA Kits)-15b as an early response to Dicer depletion silenced Pim-1 (show PIM1 ELISA Kits) kinase resulting in mitochondrial dysfunction. Rescue experiments demonstrated that suppression of miRNA-15b induction in Dicer-deleted adult hearts result in marked amelioration of cardiac dysfunction.
Dicer1 ablation impairs Shh-induced granule neuron precursor proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17 approximately 92 cluster members. This study establishes a molecular link between miRNAs and cell cycle progression in the proliferating Granule neuron precursors during normal cerebellar development and may facilitate miRNA application in treating med...
Dicer maintains the identity and function of proprioceptive sensory neurons. Results suggest that Dicer and, most likely by extension, microRNAs are crucially important for maintaining proprioception. Additionally, this study hints at the larger question of how neurons maintain their functional and molecular specificity.
this study shows that Dicer deficiency differentially impacts microglia of the developing and adult brain
this study shows that deletion Dicer1 specifically in Th17 cells protected mice from experimental autoimmune encephalomyelitis
Dicer expression in smooth muscle cells plays an essential role in vascular repair by generating anti-proliferative miRNAs.
The findings of this study further substantiate the important role of DICER1 in the maintenance of homeostasis and the regulation of inflammatory responses
The paracrine control of functions important to post-testicular sperm maturation by Dicer1-dependent factors may open new avenues for the identification of molecular targets important to male fertility control.
Dicer1-deficient NK cells failed to complete their differentiation program; Dicer1 deletion impaired key NK-cell functions: target cell killing and production of IFN-gamma (show IFNG ELISA Kits)
DICER1 pathogenic variation is associated with pleuropulmonary blastoma, cystic nephroma and Sertoli-Leydig cell tumor.
Next-Gen sequencing for DICER1 mutations of their family revealed that both twins and their mother had c.C3675A mutation.
a possible interaction of the mismatch repair system with DICER1 to cause corpus callosum agenesis
Our case also emphasizes the need for testing for DICER1 mutations in pediatric patients with ovarian SLCTs.
these findings revealed a function of Dicer in NHEJ-mediated DSB repair and the association of Dicer expression with chemoresistance in colon cancer patients.
Despite exhibiting an immunophenotype characteristic of a sex cord-stromal tumor, mutations in FOXL2 (show FOXL2 ELISA Kits) and DICER1, the 2 most common mutations hitherto reported in ovarian sex cord-stromal tumors, are not a feature of Uterine tumor resembling ovarian sex cord tumor (UTROSCT).
Place Dicer within the context of the DNA damage response by demonstrating a DNA damage-inducible phosphoswitch that causes localized processing of nuclear dsRNA by p-Dicer to promote DNA repair.
In response to UV irradiation, DICER is recruited to chromatin in a ZRF1 (show DNAJC2 ELISA Kits)-mediated manner. The H2A-ubiquitin binding protein ZRF1 (show DNAJC2 ELISA Kits) and DICER together impact on the chromatin conformation via PARP1 (show PARP1 ELISA Kits).
We investigated the frequency of DICER1 mutations in a series of 38 ovarian tumors initially diagnosed as Sertoli-Leydig cell tumors, and explored whether identified mutations were associated with specific morphologic features
Case Report: metachronous anaplastic sarcoma of the kidney and thyroid follicular carcinoma with DICER1 mutations.
Diminished androgen action during gestation induces changes in Dicer1 mRNA expression.
The primary cDNA sequence of porcine Dicer was determined, and its expression in porcine oocytes and early stage embryos was confirmed.
Studied Dicer gene expression during early bovine embryo development.An increase in Dicer expression was detected in the mature oocytes sampled (P<0.05), implying that gene repression occurs during meiosis II.
Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Muller glia-derived neuronal progenitor cells
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Dicer1, Dcr-1 homolog
, endoribonuclease Dicer
, dicer 1, ribonuclease type III
, double-stranded RNA-specific endoribonuclease type III
, double-strand-specific ribonuclease mDCR-1
, dicer 1, double-stranded RNA-specific endoribonuclease
, helicase MOI
, helicase with RNAse motif
, dsRNA-specific ribonuclease