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Exp5 exports eEF1A (show EEF1A1 Proteins) via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
miRNA biogenesis components Drosha (show DROSHA Proteins), Dgcr8 (show DGCR8 Proteins), Exportin-5 and Dicer1 (show DICER1 Proteins) are expressed in the mouse uterus and that Exportin-5 and Dicer1 (show DICER1 Proteins) appear to be the major steroid regulated components in the miRNA biogenesis pathway
Exp5 exports eEF1A (show EEF1A2 Proteins) via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
XPO5 role in microRNA biogenesis
NUP93 (show NUP93 Proteins) and exportin 5 interact with the signaling protein SMAD4 (show SMAD4 Proteins) and that NUP93 (show NUP93 Proteins) mutations abrogated interaction with SMAD4 (show SMAD4 Proteins)
Variations in XPO5 rs11077 of Korean patients are significantly associated with their risk of colorectal cancer.
Knockdown of exportins 4, 5, and 7 altered thyroid hormone receptor (show THRA Proteins) shuttling dynamics, and when exportins 5 and 7 were overexpressed, TR distribution shifted toward the cytosol.
eEF1A (show EEF1A1 Proteins) binds to Snail (show SNAI1 Proteins) transcription factors when bound to their main target, the E-cadherin (show CDH1 Proteins) promoter, facilitating their export to the cytoplasm in association with the aa-tRNA-Exportin5 complex.
data demonstrate that the exportin 5 (XPO5) rs2257082 T variant allele occurs more frequently in primary ovarian insufficiency (POI)patients than in controls, suggesting that this allele may be associated with increased POI risk
The study identifies a miR (show MLXIP Proteins)-138-RMND5A-Exportin-5 as a previously unknown miRNA processing regulatory pathway in HeLa cells.
Dicer (show DICER1 Proteins), Drosha (show DROSHA Proteins), and Exportin 5 genes were up-regulated in bladder urothelial carcinoma compared to normal urothelium. Silencing these genes induced cell proliferation inhibition and apoptosis in bladder urothelial carcinoma cells.
overall survival was significantly longer in multiple myeloma patients with C/C or A/C variant in the XPO5 gene single nucleotide polymorphism site rs11077
Exportin-5 controls Dicer1 (show DICER1 Proteins) expression post-transcriptionally.
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process.
, exportin 5
, KIAA1291 protein-like
, ran-binding protein 21