Browse our FAK (PTK2) ELISA Kits

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PTK2 Protein tyrosine Kinase 2 ELISA Kits (PTK2)
On are 34 PTK2 Protein tyrosine Kinase 2 (PTK2) ELISA Kits from 11 different suppliers available. Additionally we are shipping FAK Antibodies (706) and FAK Proteins (19) and many more products for this protein. A total of 786 FAK products are currently listed.
Fadk, FAK, FAK1, FRNK, mKIAA4203, p125FAK, pp125FAK, PPP1R71

More ELISA Kits for FAK Interaction Partners

Human PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. sp(2) -Iminosugar alpha-glucosidase (show AGLU ELISA Kits) inhibitor 1 (show PPP1R1A ELISA Kits)-C-octyl-2-oxa-3-oxocastanospermine inhibits breast cancer cell migration via beta1-integrin, Stim1 (show STIM1 ELISA Kits), and FAK signaling pathways.

  2. results suggest that Kctd20 impacts proliferation and invasion of non-small cell lung cancer through enhancing Fak and Akt (show AKT1 ELISA Kits) phosphorylation

  3. mTORC1/2 inhibition promotes reorganization of integrin/focal adhesion kinase-mediated adhesomes, induction of IGFR/IR-dependent PI3K (show PIK3CA ELISA Kits) activation, and Akt (show AKT1 ELISA Kits) phosphorylation via an integrin/FAK/IGF1R (show IGF1R ELISA Kits)-dependent process, mediating tumor drug resistance.

  4. Recruitment of Paxillin (show PXN ELISA Kits), Cdc42 (show CDC42 ELISA Kits) and N-WASP (show WASL ELISA Kits) is necessary for cell adhesion, migration and invasion induced by Estradiol in breast cancer cells.

  5. Type I collagen increased pancreatic ductal adenocarcinoma tumor initiating potential, self-renewal, and the frequency of Cancer stem cells through the activation of FAK.

  6. the administration of 10(-6) M retinoic acid (10-20 min) induces the activation of the migration-related proteins Moesin (show MSN ELISA Kits), FAK, and Paxillin (show PXN ELISA Kits) in T-47D breast cancer cells.

  7. Study demonstrates that FAK expression, but not kinase activity alone, predominantly mediates thyroid tumor growth and metastasis.

  8. The Pyk2 (show PTK2B ELISA Kits)/STAP-2 (show STAP2 ELISA Kits) interaction is a novel mechanism to regulate SDF-1alpha-dependent T-cell chemotaxis.

  9. overexpression of syndecan-1 confers to B-LCs an increased capacity to migrate in response to Tat, owing to a switch from a CXCR4/G-protein/Rac to a syndecan-1/alphavbeta3/pp60src/pp125FAK signal transduction pathway that depends on the formation of a complex in which syndecan-1 interacts with Tat via its HS-chains, with alphavbeta3 via its core protein ectodomain and with pp60src via its intracellular tail

  10. MUC5AC interacts with integrin beta4 that mediates phosphorylation of FAK at Y397 leading to lung cancer cell migration.

Xenopus laevis PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. evidence that despite the fact that FAK is in the active, open conformation at CAs (show CSE1L ELISA Kits), its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells.

  2. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

  3. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

  4. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

  5. These data suggest an important role for the FERM domain in the activation of FAK.

  6. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (show BDNF ELISA Kits), while phosphorylation at Y925 controls the rate of point contact turnover.

  7. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

  8. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Mouse (Murine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. In cardiomyocytes exposed to biomechanical stimulation, FAK accumulates in the nucleus, binds to and upregulates the transcriptional activity of MEF2c (show MEF2C ELISA Kits) through an interaction with the FAK focal adhesion targeting (FAT) domain.

  2. FAK-knockout mice were shorter and showed reduced bone volume. Disruptions of FAK function in osteoblasts reduced mRNA and protein expression of Runx2 (show RUNX2 ELISA Kits) Osterix (show SP7 ELISA Kits) and collagen-1.

  3. The remodeling of the stromal matrix by CAFs has been shown to increase tumor rigidity to indirectly regulate FAK Y397 phosphorylation in tumor cells to promote their growth and invasion. Accordingly, the Hic-5(-/-);PyMT tumor cells exhibited a reduction in FAK Y397 phosphorylation. Isolated Hic-5(-/-);PyMT CAFs were defective in stress fiber organization and exhibited reduced contractility

  4. Focal adhesion kinase (FAK) in platelets regulated their migration into the tumor microenvironment, and FAK-deficient platelets completely prevented the rebound tumor growth.

  5. dynamic changes to the extracellular matrix after injury promote fibroblast activation and inhibition of epithelial cell apoptosis in response to TGF-beta (show TGFB1 ELISA Kits) through FAK activation.

  6. Results suggest that interleukin-6 (IL-6 (show IL6 ELISA Kits)) increases VEGF-C (show VEGFC ELISA Kits) induction and lymphangiogenesis may involve, at least in part, Src (show SRC ELISA Kits)-FAK-STAT3 (show STAT3 ELISA Kits) cascade in lymphatic endothelial cells (LECs).

  7. identify FAK as a novel negative regulator of Beclin1 (show BECN1 ELISA Kits)-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth

  8. FAK is tightly associated with H3K9 methylation and negatively related to the growth of tumor-repopulating cells.

  9. FAK plays a key role in regulating macrophage behavior, which underlies the chronic progression of abdominal aortic aneurysms.

  10. FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.

Cow (Bovine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. RhoA (show RHOA ELISA Kits) and membrane fluidity mediates the spatially polarized Src (show SRC ELISA Kits)/FAK activation in response to shear stress.

  2. XIAP (show XIAP ELISA Kits) plays an essential role in shear stress-stimulated FAK phosphorylation.

  3. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C (show PKC ELISA Kits)

  4. These results suggest that TGF-beta1 (show TGFB1 ELISA Kits)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (show SRC ELISA Kits)-dependent and -independent pathways.

  5. Results suggest focal adhesion kinase is involved in thrombospondin-1 (show THBS1 ELISA Kits)-induced vascular smooth muscle cell migration.

FAK (PTK2) Antigen Profile

Antigen Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Alternative names and synonyms associated with FAK (PTK2)

  • PTK2 protein tyrosine kinase 2 (PTK2) Elisa Kit
  • protein tyrosine kinase 2 (PTK2) Elisa Kit
  • protein tyrosine kinase 2 (Ptk2) Elisa Kit
  • protein tyrosine kinase 2 (ptk2) Elisa Kit
  • PTK2 protein tyrosine kinase 2 (Ptk2) Elisa Kit
  • Fadk Elisa Kit
  • FAK Elisa Kit
  • FAK1 Elisa Kit
  • FRNK Elisa Kit
  • mKIAA4203 Elisa Kit
  • p125FAK Elisa Kit
  • pp125FAK Elisa Kit
  • PPP1R71 Elisa Kit

Protein level used designations for PTK2

FADK 1 , FAK-related non-kinase polypeptide , PTK2 protein tyrosine kinase 2 , focal adhesion kinase 1 , focal adhesion kinase-related nonkinase , protein phosphatase 1 regulatory subunit 71 , protein phosphatase 1, regulatory subunit 71 , pp125FAK , protein-tyrosine kinase 2 , focal adhesion kinase pp125FAK , focal ashension kinase 1 , p41/p43FRNK , focal adhesion kinase

100058245 Equus caballus
5747 Homo sapiens
25614 Rattus norvegicus
399286 Xenopus laevis
14083 Mus musculus
396416 Gallus gallus
475108 Canis lupus familiaris
506270 Bos taurus
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