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Browse our HMGCS2 Proteins (HMGCS2)

Full name:
3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) Proteins (HMGCS2)
On are 11 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) Proteins from 5 different suppliers available. Additionally we are shipping HMGCS2 Antibodies (36) and HMGCS2 Kits (17) and many more products for this protein. A total of 71 HMGCS2 products are currently listed.
1300002P16, B130032C06Rik, DDBDRAFT_0219349, DDBDRAFT_0219924, DDB_0219349, DDB_0219924, EMB2778, EMBRYO DEFECTIVE 2778, FKP1, FLAKY POLLEN 1, HMG-COA SYNTHASE, hmgCoA, Hmgcs1, HMGS, HYDROXYMETHYLGLUTARYL-COA SYNTHASE, mHS, Mt3h3mg, T26M18.30, T26M18_30
list all proteins Gene Name GeneID UniProt
HMGCS2 29637 P17425
HMGCS2 3158 P54868
HMGCS2 208715 Q8JZK9

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HMGCS2 Proteins (HMGCS2) by Origin

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More Proteins for HMGCS2 Interaction Partners

Arabidopsis thaliana 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) interaction partners

  1. FLAKY POLLEN1 is required for organelle development in tapetal cells and pollen coat formation. [FKP1]

Human 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) interaction partners

  1. HMGCS2 shares with ketone bodies common features in autophagic clearance of APP (show APP Proteins), suggesting that ketone bodies play an important role in HMGCS2 regulation of the autophagy.

  2. High expression of either HSD17B2 or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy.

  3. FABP7 (show FABP7 Proteins) and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast

  4. In Fe-S cluster-deficient muscles, results show a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21 (show FGF21 Proteins)).

  5. An alternative transcript of HMGCS2 carrying a deletion of exon 4, and two alternative transcripts of HMGCL (show HMGCL Proteins) with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.

  6. Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 (show FGF21 Proteins) expression

  7. Ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc (show MYC Proteins)-mediated repression of the key metabolic gene HMGCS2.

Mouse (Murine) 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) interaction partners

  1. HMGCS2 was identified as a major down-regulated protein in colonic crypts isolated from Keratin 8 (show KRT8 Proteins)-/- mice.

HMGCS2 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HMGCS2

  • 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (HMGCS2)
  • Hydroxymethylglutaryl-CoA synthase (MVA1)
  • hydroxymethylglutaryl-CoA synthase (mvaS)
  • hydroxymethylglutaryl-CoA synthase (CNC05080)
  • hydroxymethylglutaryl-coa synthase (HMCS1)
  • hydroxymethylglutaryl-CoA synthase (hgsA)
  • 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Eint_100450)
  • hydroxymethylglutaryl-CoA synthase (Mfer_0083)
  • hydroxymethylglutaryl-CoA synthase (LOC100285783)
  • 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (Hmgcs1)
  • 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (Hmgcs2)
  • 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1)
  • 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2)
  • 1300002P16 protein
  • B130032C06Rik protein
  • DDBDRAFT_0219349 protein
  • DDBDRAFT_0219924 protein
  • DDB_0219349 protein
  • DDB_0219924 protein
  • EMB2778 protein
  • EMBRYO DEFECTIVE 2778 protein
  • FKP1 protein
  • FLAKY POLLEN 1 protein
  • HMG-COA SYNTHASE protein
  • hmgCoA protein
  • Hmgcs1 protein
  • HMGS protein
  • mHS protein
  • Mt3h3mg protein
  • T26M18.30 protein
  • T26M18_30 protein

Protein level used designations for HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) , hydroxymethylglutaryl-CoA synthase 2 , hydroxymethylglutaryl-CoA synthase, mitochondrial-like , 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2 , hydroxymethylglutaryl-CoA synthase , hydroxymethylglutaryl-coa synthase , 3-hydroxy-3-methylglutaryl-CoA synthase 2 , GRMZM2G106263 , putative hydroxymethylglutaryl-CoA synthase family protein , 3-hydroxy-3-methylglutaryl coenzyme A synthase , 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) , HMG-CoA synthase , hydroxymethylglutaryl-CoA synthase 1 , hydroxymethylglutaryl-CoA synthase, cytoplasmic , 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) , hydroxymethylglutaryl-CoA synthase, mitochondrial , 3-hydroxy-3-methylglutary-Coenzyme A synthase 2

100059971 Equus caballus
100343479 Oryctolagus cuniculus
100449449 Pongo abelii
100484975 Ailuropoda melanoleuca
100581170 Nomascus leucogenys
826788 Arabidopsis thaliana
859815 Encephalitozoon cuniculi GB-M1
2798767 Listeria monocytogenes serotype 4b str. F2365
3256225 Cryptococcus neoformans var. neoformans JEC21
7446804 Thalassiosira pseudonana CCMP1335
8626645 Dictyostelium discoideum AX4
9699436 Encephalitozoon intestinalis ATCC 50506
9961791 Methanothermus fervidus DSM 2088
100285783 Zea mays
29637 Rattus norvegicus
424380 Gallus gallus
3158 Homo sapiens
607923 Canis lupus familiaris
397673 Sus scrofa
503684 Bos taurus
24450 Rattus norvegicus
208715 Mus musculus
15360 Mus musculus
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