Browse our GALE Proteins (GALE)

On are 35 UDP-Galactose-4-Epimerase (GALE) Proteins from 11 different suppliers available. Additionally we are shipping GALE Antibodies (73) and GALE Kits (3) and many more products for this protein. A total of 119 GALE products are currently listed.
1n569, 2310002A12Rik, AI323962, BA5505, BA5700, ECK0748, F15H21.11, F15H21_11, galD, galE, im:7147391, JW0742, REB1, ROOT EPIDERMAL BULGER1, ROOT HAIR DEFECTIVE 1, SDR1E1, SMU.888, UDP-GLUCOSE 4-EPIMERASE, UGE4, VFA0352, wu:fb05f01, xgale, zgc:136578
list all proteins Gene Name GeneID UniProt
GALE 74246 Q8R059
GALE 2582 Q14376
GALE 114860  

GALE Proteins (GALE) by Origin

More Proteins for GALE Interaction Partners

Arabidopsis thaliana UDP-Galactose-4-Epimerase (GALE) interaction partners

  1. This data from this study indicate the importance of UDP-D-galactose synthesis by UGE4 for the organization and function of endomembranes, especially TGN (show TG Proteins)/EEs, which are a sorting station of the secretory and vacuolar pathways.

  2. Rough mapping and whole-genome sequencing identified the mutant with altered localization of NIP5;1 as an allele of UDP-glucose 4-epimerase 4.

  3. RHD1, a UDP-glucose-4-epimerase, is a likely target of root-specific negative regulation by ethylene and that loss of RHD1 function results in a heightened sensitivity of root tissues to both ethylene and auxin. [RHD1]

  4. UGE2 and UGE4 influence growth and cell wall carbohydrate biosynthesis throughout the plant, UGE3 is specialized for pollen development, and UGE1 and UGE5 might act in stress situations.

Mouse (Murine) UDP-Galactose-4-Epimerase (GALE) interaction partners

  1. results provide evidence that the Xbp1s/GalE pathway functions as a novel regulatory nexus connecting the UPR to the characteristic postprandial metabolic changes in hepatocytes.

Human UDP-Galactose-4-Epimerase (GALE) interaction partners

  1. Mutation in UDP-galactose-4'-epimerase gene is associated with UDP-galactose-4'-epimerase deficiency.

  2. Data show the protein structure of GALE and its substrate binding and specificity. It is mutated in type III galactosemia. [review]

  3. human UDP-galactose 4'-epimerase stability is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding

  4. These data indicated a critical role of GALE in maintaining cartilage homeostasis, and suggested that GALE inhibition might contribute to OA progress.

  5. GALE variants can be arranged into three groups depending on the severity of enzyme impairment.

  6. Resulst describe the relationship among UDP-galactose 4'-epimerase activity, substrate specificity, metabolic balance, and galactose sensitivity in mammalian cells.

  7. Subtle biochemical and metabolic abnormalities detected in patients expressing these GALE alleles likely reflect, at least in part, the reduced enzymatic activity of the encoded GALE proteins.

  8. Our observations show that altered protein stability is due to misfolding and that loss or reduction of enzyme activity is responsible for the molecular defects underlying GALE-deficiency galactosemia.

GALE Protein Profile

Protein Summary

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

Alternative names and synonyms associated with GALE

  • UDP-galactose-4-epimerase (GALE)
  • UDP-galactose-4-epimerase (gale)
  • UDP-glucose 4-epimerase (RHD1)
  • UDP-galactose-4-epimerase (ECs0787)
  • UDP-galactose-4-epimerase (galE)
  • UDP-galactose 4-epimerase GalE (galE)
  • UDP-glucose 4-epimerase (galE-1)
  • UDP-glucose 4-epimerase (galE-2)
  • UDP-glucose 4-epimerase (galE)
  • UDP-galactose-4-epimerase (SG0897)
  • UDP-galactose-4-epimerase (galD)
  • UDP-galactose-4-epimerase (Ent638_1250)
  • galactose-4-epimerase, UDP (Gale)
  • UDP-galactose-4-epimerase (Gale)
  • 1n569 protein
  • 2310002A12Rik protein
  • AI323962 protein
  • BA5505 protein
  • BA5700 protein
  • ECK0748 protein
  • F15H21.11 protein
  • F15H21_11 protein
  • galD protein
  • galE protein
  • im:7147391 protein
  • JW0742 protein
  • REB1 protein
  • SDR1E1 protein
  • SMU.888 protein
  • UGE4 protein
  • VFA0352 protein
  • wu:fb05f01 protein
  • xgale protein
  • zgc:136578 protein

Protein level used designations for GALE

UDP-galactose-4-epimerase , UDP-glucose 4-epimerase , fb05f01 , UDP-galactose 4-epimerase , galactowaldenase , UDP-glucose (37.7 kD) (1N569) , UDP galactose-4'-epimerase , galactose-4-epimerase, UDP- , short chain dehydrogenase/reductase family 1E, member 1 , galactose-4-epimerase, UDP

419686 Gallus gallus
456623 Pan troglodytes
678540 Danio rerio
842752 Arabidopsis thaliana
917525 Escherichia coli O157:H7 str. Sakai
945354 Escherichia coli str. K-12 substr. MG1655
957904 Escherichia coli O157:H7 str. EDL933
1028251 Streptococcus mutans UA159
1036650 Escherichia coli CFT073
1067209 Salmonella enterica subsp. enterica serovar Typhi str. Ty2
1085150 Bacillus anthracis str. Ames
1085447 Bacillus anthracis str. Ames
1147990 Yersinia pestis KIM10+
1169457 Shewanella oneidensis MR-1
1173989 Yersinia pestis CO92
1247256 Salmonella enterica subsp. enterica serovar Typhi str. CT18
1252296 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
2687202 Geobacter sulfurreducens PCA
2763289 Yersinia pestis biovar Microtus str. 91001
2883164 Pectobacterium atrosepticum SCRI1043
2955669 Yersinia pseudotuberculosis IP 32953
3103661 Methylococcus capsulatus str. Bath
3231780 Campylobacter jejuni RM1221
3280601 Vibrio fischeri ES114
3728483 Carboxydothermus hydrogenoformans Z-2901
3779874 Shigella boydii Sb227
3868345 Sodalis glossinidius str. 'morsitans'
4714920 Yersinia enterocolitica subsp. enterocolitica 8081
5114212 Enterobacter sp. 638
74246 Mus musculus
380596 Xenopus laevis
2582 Homo sapiens
523154 Bos taurus
114860 Rattus norvegicus
487373 Canis lupus familiaris
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