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SGLT2 (show SLC5A2 Proteins)/MAP17 functions as a low-affinity Na(+)-glucose cotransporter (show SLC5A1 Proteins) in the kidney.
Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 and RPL41 (ENSG00000279483) genes in the intrahepatic cholangiocarcinoma samples when compared with the matched paratumor samples.
Data show that bortezomib induces a prosurvival response through cytoprotective autophagy and nuclear factor kappa B (NFkappaB (show NFKB1 Proteins)) nuclear translocation, which is repressed by high levels of membrane-associated protein 17 (MAP17).
In this study we found that the levels of MAP17 were related to clinical findings and survival in a cohort of 58 patients with larynx cancer
Results suggest that the use of MAP17 and SGLT1 (show SLC5A1 Proteins) markers may identify patients who are likely to exhibit a better response to treatments that boost oxidative stress in other cancer types.
MAP17 is overexpressed in late-stage breast tumors, in which oncogenic activity relies on p38 (show CRK Proteins) insensitivity to induce intracellular ROS (show ROS1 Proteins).
The Th cell cytokine-induced up-regulation of MAP17 expression may be linked to the down-regulation of filaggrin (show FLG Proteins) in normal epidermal keratinocytes, which may be associated with abnormal epidermal differentiation observed in the dermatological diseases.
Large scale genetic screening identifies MAP17 as protein bypassing TNF-alpha (show TNF Proteins)-induced growth arrest.
Independent activation of MAP17 promoter can be driven by oncogenes and might explain the common overexpression of MAP17 in human carcinomas.
Tumorigenic capability of MAP17 through a connection between sodium-coupled co-transporters and reactive oxygen species.
membrane associated protein 17 may be an endogenous regulator of cellular PDZ domain containing 1(PDZK1 (show PDZK1 Proteins)) levels by regulating PDZK1 (show PDZK1 Proteins) turnover
MAP17 1) interacts with PDZK1 (show PDZK1 Proteins) only, 2) associates with the NH2 terminus of NaPi-IIa within the PDZK1 (show PDZK1 Proteins)/NaPi-IIa/MAP17 complex, and 3) acts as an apical anchoring site for PDZK1 (show PDZK1 Proteins).
the interaction between MAP17, NHERF3 (show PDZK1 Proteins)/4, and NaPiIIa in the trans-Golgi network could be an important intermediate or alternate path in the internalization of NaPiIIa
Knockout mice for 3 members of the sodium-hydrogen regulatory factor (NHERF (show SLC9A3R1 Proteins)) family of PDZ adaptor proteins, NHERF1 (EBP50 (show SLC9A3R1 Proteins)), NHERF2 (E3KARP (show SLC9A3R2 Proteins)) and NHERF3 (PDZK1 (show PDZK1 Proteins)), have helped to show that NHERF1 (show SLC9A3R2 Proteins) is essential for both normal and mutant CFTR (show CFTR Proteins) function [review]
Systematic analysis of Pdzk1ip1 is reported.
XPteg functions as a direct transcriptional target of RA signaling to regulate pronephric tubulogenesis in Xenopus early development
expressed specifically in kidney\; increased expression is detected in renal carcinoma
PDZK1-interacting protein 1
, 17 kDa membrane-associated protein
, PDZK1 interacting protein 1
, epithelial protein up-regulated in carcinoma, membrane associated protein 17
, membrane-associated protein 17
, membrane-associated protein 17 (Map17)
, MAP-like protein
, MAP17-like protein
, membrane-associated protein
, proximal tubules-expressed gene protein
, proximal tubules-expressing