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Browse our PITX2 Proteins (PITX2)

Full name:
Paired-Like Homeodomain 2 Proteins (PITX2)
On are 12 Paired-Like Homeodomain 2 (PITX2) Proteins from 4 different suppliers available. Additionally we are shipping PITX2 Antibodies (74) and PITX2 Kits (2) and many more products for this protein. A total of 98 PITX2 products are currently listed.
9430085M16Rik, ARP1, Brx1, Brx1a, Brx1b, IDG2, IGDS, IGDS2, IHG2, IRID2, Munc30, Otlx2, pitx-2, pitx2, pitx2-A, pitx2a, Pitx2b, Pitx2c, Pitx2cbeta, Ptx2, RGS, Rieg, RIEG1, RS, xpitx2, xPtx2, XPtx2b, zgc:110508
list all proteins Gene Name GeneID UniProt
PITX2 5308 Q99697
PITX2 54284 Q9R0W1
PITX2 18741 P97474

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PITX2 Proteins (PITX2) by Origin

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More Proteins for PITX2 Interaction Partners

Xenopus laevis Paired-Like Homeodomain 2 (PITX2) interaction partners

  1. ESR1 (show ESR1 Proteins) inhibits the expression of Pitx2 gene by binding to a left side-specific enhancer region in Pitx2 gene and recruiting histone deacetylase 1 (show HDAC1 Proteins) to this region, leading to the suppression of Pitx2 gene in the left lateral plate mesoderm.

Human Paired-Like Homeodomain 2 (PITX2) interaction partners

  1. The PITX2 gene expression level in prostate cancer tissues was lower than that in benign tissues. A higher degree of PITX2 DNA methylation (show HELLS Proteins) was associated with higher tumor stage and lower survival rates. PITX2 DNA methylation (show HELLS Proteins) presents a good predictive value for prostate cancer survival.

  2. This is the first study reporting on bi-allelic changes of PITX2 potentially contributing to a more severe Axenfeld-Rieger syndrome (ARS (show SLURP1 Proteins)) phenotype.

  3. The role of PITX2 in glaucoma may be mediated partly by regulating the expression of CXCL6 and BBS5 (show BBS5 Proteins) and thus affecting immune functions and intraocular pressure.

  4. Chronic Atrial fibrillation increases Pitx2c expression in isolated human atrial myocytes

  5. ARS (show SLURP1 Proteins) is an autosomal dominant disorder with high penetration. It is primarily caused by a mutation of the pituitary homeobox 2 (PITX2) or forkhead box C1 (FOXC1 (show FOXC1 Proteins)) gene. Mutations in PITX2 on chromosome 4q25, or in FOXC1 (show FOXC1 Proteins) at 6p25, have been identified in approximately 40% to 70% of patients with ARS (show SLURP1 Proteins)

  6. Expression of PITX2 in BM of early-stage breast cancer patients is associated with risk for early disease recurrence.

  7. A novel loss-of-function PITX2 mutation (Q102L) co-segregated with tetralogy of Fallot with complete penetrance.

  8. Our study uncovers the PITX2-induced expression of TGFB1/2/3 as well as INHBA genes (p < 0.01) followed by SMAD2/3-dependent TGF-b signalling pathway in ovarian cancer cells

  9. Both ZFHX3 and PITX2c regulate expression of NPPA (show NPPA Proteins), TBX5 (show TBX5 Proteins) and NKX2.5 (show NKX2-5 Proteins).

  10. PANCR knockdown decreased PITX2c expression in differentiated cardiomyocytes, altering the transcriptome in a manner similar to PITX2c knockdown.

Mouse (Murine) Paired-Like Homeodomain 2 (PITX2) interaction partners

  1. demonstrate a dose-dependent relation between Pitx2 expression and the expression of atrial fibrillation susceptibility genes

  2. Data suggest a putative role of the homeobox protein PITX2 (PITX2B) isoform during ventricular septation as well as in the maturation of the right portion of the atrioventricular canal.

  3. Pitx2 represses left-side expression of a conserved lncRNA Playrr. Pitx2 auto-regulation directs chromatin topology to coordinate left-right transcription and organogenesis.

  4. The AP-2beta (show TFAP2B Proteins) transcription factor is an important effector of PITX2 function during corneal development, required for differentiation of corneal endothelium and establishment of angiogenic privilege.

  5. Pitx2-deficient neonatal mouse hearts failed to repair after apex (show APEX1 Proteins) resection, whereas adult mouse cardiomyocytes with Pitx2 gain-of-function efficiently regenerated after myocardial infarction

  6. This study describes a Pitx2-miRNA pathway controlling cell proliferation in myogenic cells, providing new targets to enhance the regenerative capacity of limb skeletal-muscle myogenic precursor cells for the treatment of skeletal-muscle diseases.

  7. de-regulation of both PITX2 and ENPEP (show ENPEP Proteins) could contribute to an increased risk of atrial fibrillation in carriers of disease-associated variants.

  8. Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine

  9. Pitx2c may regulate functional Left-Right asymmetry of the developing limb.

  10. The combination of Pitx2, a regulator of dental stem cells and miR (show MLXIP Proteins)-200a converts mesenchymal cells to a fully differentiated dental epithelial cell type.

Zebrafish Paired-Like Homeodomain 2 (PITX2) interaction partners

  1. This study found PITX2 to be decreased in patients with sustained Atrial Fibrillation, suggesting a PITX2 loss of function mechanism in Atrial Fibrillation.

  2. Antagonism between Nodal and Pitx2c activities sets an upper limit on parapineal cell numbers. Restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry.

  3. Pitx2, implicated in left-right asymmetry, possessed appropriate 'atypical' Pegasus (show IKZF5 Proteins) binding sites in its promoter.

  4. Data indicate that retinoic acid (RA) induces the expression patterns of genes normally expressed in the posterior tooth-forming region, such as pitx2 and dlx2b.

  5. Pitx2 is essential for proper eye and craniofacial development in zebrafish.

  6. Retinoic acid regulation of pitx2 is essential for coordinating interactions among neural crest, mesoderm, and developing eye.

  7. Zebrafish pitx2 demonstrates conserved expression during ocular and craniofacial development. Thirteen conserved noncoding sequences positioned within a gene desert as far as 1.1 Mb upstream of the human PITX2

PITX2 Protein Profile

Protein Summary

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with PITX2

  • paired-like homeodomain 2 (PITX2)
  • paired-like homeodomain 2 (pitx2-a)
  • paired-like homeodomain 2 (pitx2)
  • paired-like homeodomain transcription factor 2 (pitx-2)
  • paired-like homeodomain 3 (PITX3)
  • paired-like homeodomain 2 (Pitx2)
  • paired-like homeodomain 2 (pitx2-b)
  • paired-like homeodomain transcription factor 2 (Pitx2)
  • paired-like homeodomain transcription factor 2 (pitx2)
  • 9430085M16Rik protein
  • ARP1 protein
  • Brx1 protein
  • Brx1a protein
  • Brx1b protein
  • IDG2 protein
  • IGDS protein
  • IGDS2 protein
  • IHG2 protein
  • IRID2 protein
  • Munc30 protein
  • Otlx2 protein
  • pitx-2 protein
  • pitx2 protein
  • pitx2-A protein
  • pitx2a protein
  • Pitx2b protein
  • Pitx2c protein
  • Pitx2cbeta protein
  • Ptx2 protein
  • RGS protein
  • Rieg protein
  • RIEG1 protein
  • RS protein
  • xpitx2 protein
  • xPtx2 protein
  • XPtx2b protein
  • zgc:110508 protein

Protein level used designations for PITX2

paired-like homeodomain transcription factor 2 , cPITX2 , homeobox protein PITX2 , pituitary homeobox 2 , transcription factor Pitx2 , ALL1-responsive protein ARP1 , all1-responsive gene 1 , rieg bicoid-related homeobox transcription factor 1 , solurshin , homeodomain transcription factor 2 , rPtx2 , homeodomain transcription factor Pitx2 , BRX1 homeoprotein , orthodenticle-like homeobox 2 , paired-like homeodomain transcription factor Munc 30 , paired-like homeodomain transcription factor 2a , pitx2b

100146441 Equus caballus
373586 Xenopus laevis
461438 Pan troglodytes
549981 Xenopus (Silurana) tropicalis
100136226 Oncorhynchus mykiss
100222601 Taeniopygia guttata
100226017 Taeniopygia guttata
395862 Gallus gallus
5308 Homo sapiens
487902 Canis lupus familiaris
506721 Bos taurus
54284 Rattus norvegicus
398033 Xenopus laevis
18741 Mus musculus
30164 Danio rerio
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