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Human CELF1 Protein expressed in Wheat germ - ABIN1350750
Yu, Rao, Zou, Liu, Xiao, Ouyang, Cao, Gorospe, Wang: Competitive binding of CUGBP1 and HuR to occludin mRNA controls its translation and modulates epithelial barrier function. in Molecular biology of the cell 2013
Findings indicate that IGF2R (show IGF2R Proteins) expression is controlled posttranscriptionally by two factors that associate with Igf2r (show IGF2R Proteins) mRNA and suggest that miR (show MLXIP Proteins)-195 and CUGBP1 dampen IGF signaling by inhibiting IGF2R (show IGF2R Proteins) translation.
In the course of these studies, we found that RNA binding protein (show PTBP1 Proteins) CUGBP1 is a new tumor suppressor protein (show TP53 Proteins) which is reduced in all HBL (show LGALS1 Proteins) samples. Therefore, we generated CUGBP1 KO mice and examined HBL (show LGALS1 Proteins) signatures in the liver of these mice. Micro-array studies revealed that the HBL (show LGALS1 Proteins)-specific molecular signature is developed in livers of CUGBP1 KO mice at very early ages
Results show that CELF1 is a potential target of TUG1 interaction and could be negatively regulated by TUG1 RNA.
CUG-binding protein 1 regulates HSC (show FUT1 Proteins) activation and liver fibrogenesis.
High expression of CUGBP1 is associated with recurrence in lung adenocarcinoma.
CUG-BP1 affected the calcium release activity in single myofibers and the extent of atrophy was significantly reduced upon gene silencing of CUG-BP1 in atrophic muscle.
these data provided a comprehensive view of the CELF1 mRNA regulatory network in oral cancer
forced expression of miR (show MLXIP Proteins)-214-3p enhances the sensitivity of esophageal cancer cells to cisplatin-induced apoptosis. This effect is abrogated with rescue expression of survivin (show BIRC5 Proteins) or CUG-BP1
Expression of several genes within the CELF1 locus, including MTCH2 (show MTCH2 Proteins), were highly correlated with one another and were associated with Alzheimer's disease status.
CUGBP1 and HuR (show ELAVL1 Proteins) negate each other's effects in regulating E-cadherin (show CDH1 Proteins) translation by altering the recruitment of E-cadherin (show CDH1 Proteins) mRNA to PBs (show TSPO Proteins) and play important roles in the regulation of intestinal barrier integrity.
lncBATE10 can decoy Celf1 from Pgc1alpha, thereby protecting Pgc1alpha mRNA from repression by Celf1
Study concludes that CUGBP1 is a critical regulator of insulin secretion via activating PDE3B.
the oncoprotein gankyrin (Gank (show PSMD10 Proteins)) preferentially binds to and triggers degradation of dephosphorylated CUGBP1 (de-ph-S302-CUGBP1) or S302A mutant CUGBP1.
Our studies support the existence of an RNA regulon containing Signal Recognition Particle mRNAs that is controlled by CELF1. One implication is that altered function of CELF1 in myotonic dystrophy may contribute to changes in the extracellular matrix of affected muscle through defects in secretion
CELF1 downregulates Cyp19a1 (Aromatase (show CYP19A1 Proteins)) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.
developmental stage-specific compatibility of CELF (show CEBPD Proteins)-dependent splice variants dictates their effects on cardiac health and function
Differential expression of CELF1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.
Celf1 plays a distinctive and negative role in terminal myocyte differentiation, which partially contribute to DM1 RNA toxicity.
These results indicate that JNK2 (show MAPK9 Proteins) is essential for maintenance of normal intestinal epithelial homeostasis and maturation under biological conditions by differentially modulating HuR (show ELAVL1 Proteins) and CUGBP1.
CELF1 and CELF2 (show CELF2 Proteins) may underlie conserved, developmentally regulated, tissue-specific processes in vertebrate embryos
Results therefore suggest that Celf1 regulates proper organogenesis of endoderm-derived tissues by regulating the expression of such targets.
Celf1-dependent fine-tuning of dmrt2a (show DMRT2 Proteins) expression is essential for generating bilateral symmetry of somites and left-right asymmetric patterning during zebrafish development.
not only mRNA but also protein of brul is localized to the zebrafish germ plasm at the ends of the cleavage furrows
This "target protector and rescue assay" demonstrates that the phenotypic defects associated with CUGBP1 inactivation in Xenopus are essentially due to the deregulation of Su(H (show RBPJ Proteins)) mRNA.
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
CUG triplet repeat, RNA binding protein 1
, CUGBP Elav-like family member 1
, 50 kDa nuclear polyadenylated RNA-binding protein
, CUG RNA-binding protein
, CUG triplet repeat RNA-binding protein 1
, CUG triplet repeat, RNA-binding protein 1
, CUG-BP- and ETR-3-like factor 1
, EDEN-BP homolog
, RNA-binding protein BRUNOL-2
, bruno-like 2
, bruno-like protein 2
, deadenylation factor CUG-BP
, embryo deadenylation element binding protein
, embryo deadenylation element-binding protein homolog
, nuclear polyadenylated RNA-binding protein, 50-kD
, brain protein F41
, deadenylation factor EDEN-BP
, EDEN-BP/Bruno-like protein
, CUG triplet repeat RNA-binding protein 1-A
, CUG-BP- and ETR-3-like factor 1-A
, CUGBP Elav-like family member 1-A
, RNA-binding protein BRUNOL-2-A
, bruno-like protein 2-A
, embryo deadenylation element-binding protein A