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Human DDX3X Protein expressed in HEK-293 Cells - ABIN2719282
Lin, Sivakumaran, Jones, Li, Harper, Wei, Jin, Rustanti, Meunier, Spann, Harrich: A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1. in Retrovirology 2015
data have demonstrated that Venezuelan equine encephalitis virus (VEEV)-nsP3 associates with DDX1 and DDX3 in infected cells to facilitate viral multiplication; determined that VEEV-nsP3 interacts with a pre-formed translational complex, comprising of DX3:eIF4A:eIF4G:PABP to potentially aid in translation of viral proteins.
Data suggest that DEAD-box helicase 3 (DDX3X) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein (show BLZF1 Proteins) 1 (PABPC1 (show PABPC1 Proteins)) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (via gene silencing with the CRISPR-Cas (show CSE1L Proteins) system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line.
The article describes RNA remodeling activity of human DDX3X and Caenorhabditis elegans LAF (show HPD Proteins)-1 tuned by protein concentration, RNA length, and ATP.
the role of DDX3 in sarcomas
DDX3 directly regulates TRAF3 (show TRAF3 Proteins) ubiquitination and acts as a scaffold to co-ordinate assembly of signaling complexes downstream from MAVS (show MAVS Proteins).
Here we identify the DEAD-box helicase 3 (DDX3) as a novel interaction partner of Y. enterocolitica YopM and present the three-dimensional structure of a YopM:DDX3 complex
Here, the authors show that herpes simplex virus 1 gene expression, replication, and propagation depend on optimal DDX3X protein levels.
de novo heterozygous DDX3X variants should be considered not only in females with unexplained ID, but also in individuals with a clinical diagnosis of T-CS.
high metastatic DDX3 expression correlates with worse survival, implying that DDX3 is a potential therapeutic target in metastatic breast cancer, in particular in the clinically important group of TN patients.
Herein, we showed for the first time, to our knowledge, that the inhibition of DDX3 by a small molecule could be successfully exploited for the development of a broad spectrum antiviral agent.
This study demonstrated that DDX3 regulates the translation of both Prkaca and Rac1 mRNAs in neurons and therefore maintains the PKA-Rac1 signaling axis at neurite terminals for both neurite outgrowth and dendritic spine formation.
Targeted Ddx3x ablation in the epiblast leads to widespread apoptosis and abnormal growth, which causes embryonic lethality in the Sox2-cre/+;Ddx3x(flox)/Y mutant around E11.5.These results have uncovered that mouse Ddx3x is essential for both embryo and extraembryonic development
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. Alternative splicing results in multiple transcript variants.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3
, ATP-dependent RNA helicase DDX3X-like
, ATP-dependent RNA helicase DDX3X
, DEAD box protein 3, X-chromosomal
, DEAD box, X isoform
, DEAD/H box-3
, helicase like protein 2
, helicase-like protein 2
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
, ATP-dependent RNA helicase DDX3Y
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 Y-linked
, D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3
, D1Pas1-related sequence 2
, DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3
, DEAD box RNA helicase DEAD3
, DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2)
, embryonic RNA helicase
, fibroblast growth factor inducible 14